Poor dead cuttlefish

It looks like it might have potential as a test bed — but there seem to be sacrifices in memory bandwidth even while providing vastly more than consumer cards. I’m not sure how this affects inference times and would be interested to know…

I guess it depends upon the license of the code — my guess is that any agreement saying you cannot use the data generated from the publically available code for commercial purposes is difficult to enforce.

If you mean the online server….

You risk this being considered a disclosure I think

I agree — perhaps it’s time to require proven implementation in other lab environments as a part of the peer review process. These are methodological advances rather than fundamental discoveries.

Peer review and publication is now slower than model training/iteratiin and testing — it’s a failure point of the journal system that’s been creeping up on us for a while.

Some of this reflects a conversation I had with Anthony Green about the application of de novo only to enzymes that carry out non-natural enzyme function. The issue fundamentally is that all definitions of de novo are built from contrasting with “nature,” the knowledge of which is incomplete.

Congrats, Martin!

Internationally oriented grants are not bad as your team offers a unique value added element; but have you been targeted your applications around tool development or a scientific question?

I have had representatives from companies ask me how well some of the more common algorithms work as a user; and while I can generally be positive, it’s always with a caveat — you need to understand how to read/edit code, there are unpublished best practices, their capabilities are context dependent

They do in general — the deviations in the cities are often related to forced foot traffic flows…

Always loved this! How long did it take you to find the music to accompany it?

So all proteins are in a superposition of folded and unfolded states; sounds about right actually.

This is going to be the death of the Europe-to-US conference attendance. I’m not sure Universities would insure trips where targeted deportation is a risk.

Scientific societies are in general fairly conservative entities, chemists are in general the most conservative scientists, so it doesn’t surprise me that academic societies of chemists can be regressive.

Hello, I’m a biophysical chemist and protein designer at the University of Portsmouth — could I be added to the science feed?

www.port.ac.uk/about-us/str...

The manuscript has a bit for everyone: manual protein design to preserve enzymatic thermodynamic properties with confirmatory structure, careful activity measurements, pilot scale bioprocessing of post-consumer plastic, synergy and more!