Liam Faller
@liamfaller.bsky.social
Cancer researcher, RNA biologist, and all round science geek, based at the University of Bristol. Ribosomes FTW.
You smashed it Dr Ramalho! Well done!
November 24, 2025 at 7:25 PM
You smashed it Dr Ramalho! Well done!
Couldn't make it today, but I'll see you there tomorrow!
September 8, 2025 at 9:08 AM
Couldn't make it today, but I'll see you there tomorrow!
Kudos to Anna Dopler (not on the socials) who led both this study, and the P-stalk one! Thanks to @nar-cancer-editor.bsky.social for publishing it too!
September 1, 2025 at 8:40 PM
Kudos to Anna Dopler (not on the socials) who led both this study, and the P-stalk one! Thanks to @nar-cancer-editor.bsky.social for publishing it too!
I loved this project because we were looking at 2 members of the ribosome, that had essentially the same effect (reduced antigen presentation), but through completely different mechanisms. Just shows how much there is still to learn about the ribosome!
September 1, 2025 at 8:40 PM
I loved this project because we were looking at 2 members of the ribosome, that had essentially the same effect (reduced antigen presentation), but through completely different mechanisms. Just shows how much there is still to learn about the ribosome!
Turns out they aren't! The P-stalk controls the translation of HLA (and other cytokine-regulated genes), while uL14 regulates the generation and processing of peptides, resulting in the production of more unstable peptides, and reduced presentation as a result.
September 1, 2025 at 8:40 PM
Turns out they aren't! The P-stalk controls the translation of HLA (and other cytokine-regulated genes), while uL14 regulates the generation and processing of peptides, resulting in the production of more unstable peptides, and reduced presentation as a result.
A few years ago the Restifo lab showed that another ribosomal protein (uL14) was also essential for antigen processing and presentation. We wondered whether these two proteins from the same complex were doing the same thing.
www.nature.com/articles/nat...
www.nature.com/articles/nat...
Identification of essential genes for cancer immunotherapy - Nature
The authors describe a two-cell-type CRISPR screen to identify tumour-intrinsic genes that regulate the sensitivity of cancer cells to effector T cell function.
www.nature.com
September 1, 2025 at 8:40 PM
A few years ago the Restifo lab showed that another ribosomal protein (uL14) was also essential for antigen processing and presentation. We wondered whether these two proteins from the same complex were doing the same thing.
www.nature.com/articles/nat...
www.nature.com/articles/nat...
This is a follow on from our Cell paper last year, where we showed that the ribosomal P-stalk was crucial for cellular responses to cytokines.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
P-stalk ribosomes act as master regulators of cytokine-mediated processes
Cytokines remodel the ribosome to incorporate the P-stalk, therefore altering the
translation of mRNAs involved in cytokine responses.
www.cell.com
September 1, 2025 at 8:40 PM
This is a follow on from our Cell paper last year, where we showed that the ribosomal P-stalk was crucial for cellular responses to cytokines.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...