Lew Lab @ WashU
@lewlab.com
Playing with #singlemolecules, bending light, and algorithms to see really small things. Led by Matthew Lew, Associate Professor @WashUESE @WashUengineers @WashU #superresolution #microscopy #SMLM #computationalimaging
Very happy to share this news of my election to become an #OpticaFellow. I'm grateful to my many students and mentors over the years. Happy Thanksgiving!
Meet the new #OpticaFellows!
The Optica Board of Directors is pleased to announce that 121 members from 23 countries have been elected as Fellows for their outstanding contributions and service to Optica and the community.
Find the full class: https://bit.ly/4rgXHtn
The Optica Board of Directors is pleased to announce that 121 members from 23 countries have been elected as Fellows for their outstanding contributions and service to Optica and the community.
Find the full class: https://bit.ly/4rgXHtn
November 25, 2025 at 10:15 PM
Very happy to share this news of my election to become an #OpticaFellow. I'm grateful to my many students and mentors over the years. Happy Thanksgiving!
Happy to share our recent review in @natphoton.nature.com on #singlemolecule #orientation #localization #microscopy, co-authored with Sophie Brasselet @cnrs.fr @institutfresnel.bsky.social. See molecule motions and rotations in action! doi.org/10.1038/s415... @washuengineers.bsky.social @washu.edu
Single-molecule orientation and localization microscopy - Nature Photonics
The Review discusses recent advances in single-molecule orientation and localization microscopy (SMOLM) along with remaining challenges and promises for future developments of the field.
doi.org
September 18, 2025 at 7:41 PM
Happy to share our recent review in @natphoton.nature.com on #singlemolecule #orientation #localization #microscopy, co-authored with Sophie Brasselet @cnrs.fr @institutfresnel.bsky.social. See molecule motions and rotations in action! doi.org/10.1038/s415... @washuengineers.bsky.social @washu.edu
Congratulations to Brian Sun @brian_smtt, who was awarded a 2025-26 #WashU #ISP fellowship! @washumedicine.bsky.social @washuengineers.bsky.social @washu.edu
September 4, 2025 at 9:34 PM
Congratulations to Brian Sun @brian_smtt, who was awarded a 2025-26 #WashU #ISP fellowship! @washumedicine.bsky.social @washuengineers.bsky.social @washu.edu
Reposted by Lew Lab @ WashU
Thx again @joshtpm.bsky.social for sharing to our feed...THIS is the critical data needed to fuel our fight to stop Trump regimists from killing millions of American w/ their criminal cuts to agencies like #CDC.
zurl.co/uJUDQ
Fight back with us here zurl.co/TLiCg
#StandUpForScience
#SaveCDC
zurl.co/uJUDQ
Fight back with us here zurl.co/TLiCg
#StandUpForScience
#SaveCDC
The CDC Data Project
In the proposed FY26 budget, programs that help Americans live safer,
healthier, longer lives are on the chopping block.
www.cdcdataproject.org
June 18, 2025 at 4:15 PM
Thx again @joshtpm.bsky.social for sharing to our feed...THIS is the critical data needed to fuel our fight to stop Trump regimists from killing millions of American w/ their criminal cuts to agencies like #CDC.
zurl.co/uJUDQ
Fight back with us here zurl.co/TLiCg
#StandUpForScience
#SaveCDC
zurl.co/uJUDQ
Fight back with us here zurl.co/TLiCg
#StandUpForScience
#SaveCDC
Reposted by Lew Lab @ WashU
Big shout out to rising M4 and CWRU MSTP student Eshan King - whose paper came out in @aaas.org Science Advances. connecting the fields of PK-PD and evolutionary modeling using fitness seascapes. #mathevo #mathonco
@cbo.bsky.social @sandyanderson.bsky.social
www.science.org/doi/10.1126/...
@cbo.bsky.social @sandyanderson.bsky.social
www.science.org/doi/10.1126/...
Fitness seascapes are necessary for realistic modeling of the evolutionary response to drug therapy
Computational and experimental studies of drug resistance evolution give insights into why some bacteria become resistant.
www.science.org
June 13, 2025 at 10:46 PM
Big shout out to rising M4 and CWRU MSTP student Eshan King - whose paper came out in @aaas.org Science Advances. connecting the fields of PK-PD and evolutionary modeling using fitness seascapes. #mathevo #mathonco
@cbo.bsky.social @sandyanderson.bsky.social
www.science.org/doi/10.1126/...
@cbo.bsky.social @sandyanderson.bsky.social
www.science.org/doi/10.1126/...
"A new polarized dual-view inverted selective-plane illumination microscope (pol-diSPIM), coupled with engineering insights provided by its imaging model, offers an exciting way forward." Matt's commentary is online in PNAS doi.org/10.1073/pnas...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
doi.org
May 12, 2025 at 3:16 PM
"A new polarized dual-view inverted selective-plane illumination microscope (pol-diSPIM), coupled with engineering insights provided by its imaging model, offers an exciting way forward." Matt's commentary is online in PNAS doi.org/10.1073/pnas...
We will be at “ #Optica Biophotonics Congress: Optics in the Life Sciences” in Coronado, CA, tomorrow! Yiyang and Matt will be speaking in the #Superresolution (NM1C) session on Monday morning, April 21, in the Aurora room.
www.optica.org/events/congr...
www.optica.org/events/congr...
Schedule | Optica
Optica is the leading society in optics and photonics. Quality information and inspiring interactions through publications, meetings, and membership.
www.optica.org
April 20, 2025 at 2:16 PM
We will be at “ #Optica Biophotonics Congress: Optics in the Life Sciences” in Coronado, CA, tomorrow! Yiyang and Matt will be speaking in the #Superresolution (NM1C) session on Monday morning, April 21, in the Aurora room.
www.optica.org/events/congr...
www.optica.org/events/congr...
A wonderful collaboration between us, @rohitpappu68.bsky.social and the Knowles lab is now online, exploring anisotropies of molecules at the interfaces of RNA condensates! Congratulations Nadia, Mina, and Yuanxin! @washuengineers.bsky.social @washu.bsky.social
We investigated the interfacial orientations of scaffold molecules vs. adsorbents in model condensates formed by pairs of RNA molecules with PEG. Experiments identify purine-rich RNAs as scaffolds & pyrimidine-rich RNAs as adsorbents that undergo wetting transitions.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Differential interactions determine anisotropies at interfaces of RNA-based biomolecular condensates - Nature Communications
Experiments and computations show that the organization and dynamics of molecules within and at interfaces of biomolecular condensates are governed by differential interaction strengths leading to the...
www.nature.com
April 11, 2025 at 5:17 PM
A wonderful collaboration between us, @rohitpappu68.bsky.social and the Knowles lab is now online, exploring anisotropies of molecules at the interfaces of RNA condensates! Congratulations Nadia, Mina, and Yuanxin! @washuengineers.bsky.social @washu.bsky.social
TO THE AMERICAN PEOPLE #sciencesky www.nytimes.com/interactive/...
Read the Letter
Researchers at academic institutions nationwide say that U.S. science is being dismantled.
www.nytimes.com
April 1, 2025 at 4:43 AM
TO THE AMERICAN PEOPLE #sciencesky www.nytimes.com/interactive/...
Nice coverage of our recent #PhysicalReviewLetter by @shawnballard.bsky.social "In molecular imaging, details matter" @washuengineers.bsky.social
engineering.washu.edu/news/2025/In...
engineering.washu.edu/news/2025/In...
In molecular imaging, details matter
Matthew Lew and Yiyang Chen developed a new method to improve precision in molecular imaging
engineering.washu.edu
March 21, 2025 at 4:14 AM
Nice coverage of our recent #PhysicalReviewLetter by @shawnballard.bsky.social "In molecular imaging, details matter" @washuengineers.bsky.social
engineering.washu.edu/news/2025/In...
engineering.washu.edu/news/2025/In...
Reposted by Lew Lab @ WashU
This semesters Biophysical Evening seminar will be given by Matthew Lew, Professor in Electrical & Systems Engineering at WashU
"Single-Molecule Orientation-Localization Microscopy: New Challenges and Biophysical Insights"
Thurs, March 20th 4-5 PM, Connor Auditorium
"Single-Molecule Orientation-Localization Microscopy: New Challenges and Biophysical Insights"
Thurs, March 20th 4-5 PM, Connor Auditorium
March 14, 2025 at 6:38 PM
This semesters Biophysical Evening seminar will be given by Matthew Lew, Professor in Electrical & Systems Engineering at WashU
"Single-Molecule Orientation-Localization Microscopy: New Challenges and Biophysical Insights"
Thurs, March 20th 4-5 PM, Connor Auditorium
"Single-Molecule Orientation-Localization Microscopy: New Challenges and Biophysical Insights"
Thurs, March 20th 4-5 PM, Connor Auditorium
Reposted by Lew Lab @ WashU
"Single-flurogen" is key, allows them to view condensate hubs that are normally a needle in a haystack to find. The use of a single chemical probe means they don't get conflicting signals. 🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Single-fluorogen imaging reveals distinct environmental and structural features of biomolecular condensates - Nature Physics
Experiments confirm the prediction that fluid-like biomolecular condensates are defined by spatially inhomogeneous organization of the underlying molecules.
www.nature.com
March 14, 2025 at 2:56 PM
"Single-flurogen" is key, allows them to view condensate hubs that are normally a needle in a haystack to find. The use of a single chemical probe means they don't get conflicting signals. 🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Lew Lab @ WashU
With bsky.app/profile/lewl... we peered into condensates using single fluorogen imaging. Nanoscale hubs form, move, & disassemble on a range of timescales. A structural basis for condensate viscoelasticity. Need to rethink popular ideas. #Condensates≠simple-liquids
www.nature.com/articles/s41...
www.nature.com/articles/s41...
bsky.app
March 14, 2025 at 10:39 AM
With bsky.app/profile/lewl... we peered into condensates using single fluorogen imaging. Nanoscale hubs form, move, & disassemble on a range of timescales. A structural basis for condensate viscoelasticity. Need to rethink popular ideas. #Condensates≠simple-liquids
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Lew Lab @ WashU
Label-free Single Molecule Sensing -- the first conference in this Gordon Research Conference series. Outstanding distinguished invited speaker program just announced: www.grc.org/label-free-s...
Submit your applications early!
#singlemolecule #labelfree
Submit your applications early!
#singlemolecule #labelfree
2025 Label-Free Single Molecule Sensing Conference GRC
The 2025 Gordon Research Conference on Label-Free Single Molecule Sensing will be held in Easton, Massachusetts. Apply today to reserve your spot.
www.grc.org
March 10, 2025 at 3:48 PM
Label-free Single Molecule Sensing -- the first conference in this Gordon Research Conference series. Outstanding distinguished invited speaker program just announced: www.grc.org/label-free-s...
Submit your applications early!
#singlemolecule #labelfree
Submit your applications early!
#singlemolecule #labelfree
Happy to share #YiyangChen17 's article in #PhysRevLett! What happens when you use a #polarization #microscope to look at a pair of molecules? They look like a #wobbling #singlemolecule! No 🔬 can tell the difference! doi.org/10.1103/Phys... @washu.bsky.social @washuengineers.bsky.social
March 11, 2025 at 1:25 AM
Happy to share #YiyangChen17 's article in #PhysRevLett! What happens when you use a #polarization #microscope to look at a pair of molecules? They look like a #wobbling #singlemolecule! No 🔬 can tell the difference! doi.org/10.1103/Phys... @washu.bsky.social @washuengineers.bsky.social
Reposted by Lew Lab @ WashU
In this Q&A, we asked why they organized Stand Up for Science. Here are the answers:
www.nature.com/articles/s41...
@leslie-bern.bsky.social
@emmalovesscience.bsky.social
@cdelawalla.bsky.social
@jpflores.bsky.social
@samschuelstein.bsky.social
@standupforscience.bsky.social
www.nature.com/articles/s41...
@leslie-bern.bsky.social
@emmalovesscience.bsky.social
@cdelawalla.bsky.social
@jpflores.bsky.social
@samschuelstein.bsky.social
@standupforscience.bsky.social
Why we organized ‘Stand Up For Science’ - Nature Human Behaviour
In the USA, the Trump administration has signed executive orders that impose censorship on key areas of scientific research, strip government scientists of their jobs and reduce federal funding for sc...
www.nature.com
March 10, 2025 at 9:04 PM
In this Q&A, we asked why they organized Stand Up for Science. Here are the answers:
www.nature.com/articles/s41...
@leslie-bern.bsky.social
@emmalovesscience.bsky.social
@cdelawalla.bsky.social
@jpflores.bsky.social
@samschuelstein.bsky.social
@standupforscience.bsky.social
www.nature.com/articles/s41...
@leslie-bern.bsky.social
@emmalovesscience.bsky.social
@cdelawalla.bsky.social
@jpflores.bsky.social
@samschuelstein.bsky.social
@standupforscience.bsky.social
Scary statistics:
Fake papers are contaminating the world’s scientific literature, fueling a corrupt industry and slowing legitimate lifesaving medical research theconversation.com/fake-papers-...
Fake papers are contaminating the world’s scientific literature, fueling a corrupt industry and slowing legitimate lifesaving medical research theconversation.com/fake-papers-...
Fake papers are contaminating the world’s scientific literature, fueling a corrupt industry and slowing legitimate lifesaving medical research
‘Paper mills’ are contaminating the world’s scholarly output with fake papers that hinder research. Lifesaving biomedical fields are especially hard hit.
theconversation.com
January 29, 2025 at 4:11 PM
Scary statistics:
Fake papers are contaminating the world’s scientific literature, fueling a corrupt industry and slowing legitimate lifesaving medical research theconversation.com/fake-papers-...
Fake papers are contaminating the world’s scientific literature, fueling a corrupt industry and slowing legitimate lifesaving medical research theconversation.com/fake-papers-...
Merry Christmas! Our newest review of #singlemolecule #orientation localization microscopy is now online in #qrb. doi.org/10.1017/S003... We hope it is useful to users and technologists alike! @washu.bsky.social #WashU
December 24, 2024 at 11:23 PM
Merry Christmas! Our newest review of #singlemolecule #orientation localization microscopy is now online in #qrb. doi.org/10.1017/S003... We hope it is useful to users and technologists alike! @washu.bsky.social #WashU
Reposted by Lew Lab @ WashU
“I look forward to continuing my career as a perpetual student.” Portrait of Nobel Laureate W.E. Moerner for the @nationalacademies.org #NewHeroes
November 21, 2024 at 2:28 PM
“I look forward to continuing my career as a perpetual student.” Portrait of Nobel Laureate W.E. Moerner for the @nationalacademies.org #NewHeroes
Getting started #singlemolecule go.bsky.app/CteFZM5
November 18, 2024 at 6:06 PM
Getting started #singlemolecule go.bsky.app/CteFZM5
Reposted by Lew Lab @ WashU
Single-Molecule Orientation Imaging Reveals the Nano-Architecture of Amyloid Fibrils Undergoing Growth and Decay https://www.biorxiv.org/content/10.1101/2024.03.24.586510v1
Single-Molecule Orientation Imaging Reveals the Nano-Architecture of Amyloid Fibrils Undergoing Growth and Decay https://www.biorxiv.org/content/10.1101/2024.03.24.586510v1
Amyloid-beta (A{beta}42) aggregates are characteristic signatures of Alzheimer's disease, but probin
www.biorxiv.org
March 28, 2024 at 1:47 AM
Single-Molecule Orientation Imaging Reveals the Nano-Architecture of Amyloid Fibrils Undergoing Growth and Decay https://www.biorxiv.org/content/10.1101/2024.03.24.586510v1