Leoj
@leo1234j.bsky.social
Reposted by Leoj
🚨Our new paper is out!🚨 We uncover a protective mechanism of the rare APOE3 Christchurch (R136S) mutation against tauopathy—by suppressing microglial cGAS–STING–interferon (IFN) pathway, a key inflammatory axis triggered by tau. www.sciencedirect.com/science/arti...
The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway
The Christchurch mutation (R136S) in the APOE3 (E3S/S) gene is associated with attenuated tau load and cognitive decline despite the presence of a cau…
www.sciencedirect.com
June 24, 2025 at 12:58 PM
🚨Our new paper is out!🚨 We uncover a protective mechanism of the rare APOE3 Christchurch (R136S) mutation against tauopathy—by suppressing microglial cGAS–STING–interferon (IFN) pathway, a key inflammatory axis triggered by tau. www.sciencedirect.com/science/arti...
Reposted by Leoj
Beautiful spatial transcriptomics of developing meninges and meningiomas. Hints into the origins of meningiomas arising from the dural border 🤩🧐
Cell atlas of the developing human meninges reveals a dura origin of meningioma
The vertebrate central nervous system is enveloped by the meninges, consisting of the pia, arachnoid, and dura layers. The arachnoid is hypothesised to give rise to the most common primary intracrania...
www.biorxiv.org
July 31, 2025 at 4:20 AM
Beautiful spatial transcriptomics of developing meninges and meningiomas. Hints into the origins of meningiomas arising from the dural border 🤩🧐
Reposted by Leoj
Post-doctoral position alert!
August 5, 2025 at 7:49 PM
Post-doctoral position alert!
Reposted by Leoj
rAAV-miniBEND: A targeted vector for brain endothelial cell gene delivery and cerebrovascular malformation modeling https://www.biorxiv.org/content/10.1101/2025.06.10.658979v1
June 15, 2025 at 9:15 PM
rAAV-miniBEND: A targeted vector for brain endothelial cell gene delivery and cerebrovascular malformation modeling https://www.biorxiv.org/content/10.1101/2025.06.10.658979v1