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leandroquadrana.bsky.social
Q-Lab
@leandroquadrana.bsky.social
120 followers 100 following 6 posts
Investigating transposable elements, epigenetics, and genomics. CNRS - University Paris-Saclay. France
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pierrebaduel.bsky.social
Happy to share the results of a long-haul post-doc project, now online @science.org, aiming at understanding the rules of transgeneration epigenetic inheritance over TEs in plants and its extent and impact in nature. More below!
doi.org/10.1126/scie...
Transposable elements are vectors of recurrent transgenerational epigenetic inheritance
DNA methylation loss at transposable elements (TEs) can affect neighboring genes and be epigenetically inherited in plants, yet the determinants and significance of this additional system of inheritan...
doi.org
September 18, 2025 at 6:35 PM
Reposted by Q-Lab
matthiassoller.bsky.social
Cool story - SOS splicing to remove transposons in mRNA! Though not by the spliceosome.

www.biorxiv.org/content/10.1...
An RNA Splicing System that Excises Transposons from Animal mRNAs
All genomes harbor mobile genetic parasites called transposable elements (TEs). Here we describe a system, which we term SOS splicing, that protects C. elegans and human genes from DNA transposon-medi...
www.biorxiv.org
June 28, 2025 at 9:11 AM
Reposted by Q-Lab
petrovadmitri.bsky.social
Flybase lost all of the NIH support overnight - it is a disaster for the community. Please consider donating. I just did! www.philanthropy.cam.ac.uk/give-to-camb...
Drosophila Genetic Database
The Drosophila Genetic Database, FlyBase, is on the brink of collapse due to the sudden termination of the FlyBase NIH grant, which includes salaries for 5 literature curators based at the University ...
www.philanthropy.cam.ac.uk
June 3, 2025 at 6:23 PM
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hendersi.bsky.social
A three year postdoctoral position is available in my group, investigating plant centromere structure, function and evolution @camplantsci.bsky.social
www.jobs.cam.ac.uk/job/51488/
Research Assistant / Research Associate (Fixed Term) - Job Opportunities - University of Cambridge
Research Assistant / Research Associate (Fixed Term) in the Department of Plant Sciences at the University of Cambridge.
www.jobs.cam.ac.uk
May 30, 2025 at 12:13 PM
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borglab.bsky.social
Our preprint has now found a wonderful home in @molbioevol.bsky.social. Shout out to our collaborators in the Mozgova lab too 💚
April 18, 2025 at 12:10 PM
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maxvcg.bsky.social
See you at Jussieu in Paris tomorrow at 1:30 PM! We will march by the Statue of Liberty at Luxembourg Garden, a great symbol of our treasured alliance and shared values! 🧪🗽 @standupforscifr.bsky.social @sufs-paris-rp.bsky.social @standupforscience.bsky.social
cnrs.fr CNRS @cnrs.fr · Mar 6
#Communiqué 🗞️ Le CNRS exprime sa solidarité avec les scientifiques exerçant aux États-Unis, où la liberté académique est aujourd'hui mise à l’épreuve.

👉 www.cnrs.fr/fr/presse/le...
March 6, 2025 at 3:18 PM
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itaiyanai.bsky.social
When your kids ask you what you did to save US science in the crisis of ‘25, you will say that you showed up! Please spread the word and join us!!
@standupforscience.bsky.social
March 3, 2025 at 9:53 PM
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plantevolution.bsky.social
In our latest @biorxiv-genomic.bsky.social preprint, we describe our approach to use PacBio HiFi reads to detect somatic TE transposition -- good enough to detect rare events that are present in only single cells. Led by Andrea Movilli.
#plantscience
www.biorxiv.org/content/10.1...
Diagram of somatic TE insertions across the A. thaliana genome
February 10, 2025 at 10:57 AM
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dcb40.bsky.social
Very nice new paper from my neighbours www.biorxiv.org/content/10.1...
CRISPR targeting of H3K4me3 activates gene expression and unlocks centromeric crossover recombination in Arabidopsis
H3K4me3 is a fundamental and highly conserved chromatin mark across eukaryotes, playing a central role in many genome-related processes, including transcription, maintenance of cell identity, DNA dama...
www.biorxiv.org
February 11, 2025 at 12:06 PM
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biorxiv-genomic.bsky.social
Long-read detection of transposable element mobilization in the soma of hypomethylated Arabidopsis thaliana individuals https://www.biorxiv.org/content/10.1101/2025.02.07.637047v1
February 9, 2025 at 2:42 AM
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peterskrinjar.bsky.social
Excited to share our latest preprint evaluating AlphaFold3, Boltz-1, Chai-1 and Protenix for predicting protein-ligand interactions, featuring our newly introduced benchmark dataset 🌹Runs N’ Poses🌹!

www.biorxiv.org/content/10.1...

🧵👇 (1/n)
Have protein-ligand co-folding methods moved beyond memorisation?
Deep learning has driven major breakthroughs in protein structure prediction, however the next critical advance is accurately predicting how proteins interact with other molecules, especially small mo...
www.biorxiv.org
February 8, 2025 at 10:02 AM
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events.embl.org
📣 #EMBOMobileGenome is open for registrations!

Assembling experts in genomics, epigenetics, structural biology, evolutionary biology, and developmental biology to discuss the broad impact of TEs on organismal biology. 🧬🔍

📜 Submit abstract by 29 July!
👉🏼 https://s.embl.org/mge25-01-bl
January 27, 2025 at 3:13 PM
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deborahbourchis.bsky.social
Dear all, registrations are open for the Mobile Genome @EMBO workshop. Many slots for posters, short talks but also long talks for last minute groundbreaking results! Let’s meet again on Nov 4-7, 2025 in Heidelberg. www.embl.org/about/info/c...
The mobile genome: genetic and physiological impacts of transposable elements
www.embl.org
January 27, 2025 at 7:58 AM
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gonzalezlabbcn.bsky.social
You have plenty of time to send us your abstracts, but please block the dates in your calendar already! Looking forward to welcoming you in Heidelberg!! #EMBOMobileGenome! @events.embl.org
events.embl.org EMBL Events @events.embl.org · Jan 27
📣 #EMBOMobileGenome is open for registrations!

Assembling experts in genomics, epigenetics, structural biology, evolutionary biology, and developmental biology to discuss the broad impact of TEs on organismal biology. 🧬🔍

📜 Submit abstract by 29 July!
👉🏼 https://s.embl.org/mge25-01-bl
January 27, 2025 at 6:57 PM
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bardinlab.bsky.social
A sit-in Monday Jan 27th 16h30 will happen in front of the College de France in protest against the government cuts to higher education and research.
January 25, 2025 at 1:51 PM
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rokofler.bsky.social
super proud - our new work about the invasions triggered by two troublesome TEs in Nat. Comm. www.nature.com/articles/s41...
Double trouble: two retrotransposons triggered a cascade of invasions in Drosophila species within the last 50 years - Nature Communications
Horizontal transfer of genetic material in eukaryotes has rarely been documented over short evolutionary timescales. Here, the authors show that two transposable elements, Shellder and Spoink, invaded...
www.nature.com
January 9, 2025 at 8:01 AM
Reposted by Q-Lab
gbeauclair.bsky.social
The Institute for Integrative Biology of the Cell (I2BC) is seeking to recruit new group leaders to join the Virology Department.
The application deadline is March 15th, 2025
www.i2bc.paris-saclay.fr
www.i2bc.paris-saclay.fr/wp-content/uploads/2025/01/I2BC-Virology-call_2025.pdf
January 8, 2025 at 9:03 PM
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shahlab.bsky.social
My division at UCLA is recruiting a new Director for our Institute for Quantitative and Computational Biosciences. We're a fun cross-departmental community focused on quantitative biology education and research. Consider applying!

recruit.apo.ucla.edu/JPF10007
Director, Institute for Quantitative and Computational Biosciences
University of California, Los Angeles is hiring. Apply now!
recruit.apo.ucla.edu
January 6, 2025 at 11:56 PM
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deborahbourchis.bsky.social
The international Curie « Noncoding Genome » course has been revamped! 👉 Dark genome in cell plasticity and heterogeneity. A session on TEs #TEsky with M.E. Torres Padilla, D.Trono and @aktast.bsky.social. Master, PhD and postdoc fellows, a week in Paris during the Spring?
Apply before Feb 15th
📌
November 28, 2024 at 7:21 PM
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hendersi.bsky.social
Natural variation modifies centromere proximal meiotic crossover frequency and segregation distortion in Arabidopsis thaliana biorxiv.org/content/10.1... new work from us on centromere inheritance and organisation @matt-naish.bsky.social @plantevolution.bsky.social @genomeevolution.bsky.social
January 6, 2025 at 7:43 AM
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raphmercier.bsky.social
We are still waiting for applications to join us as a group leader in the department of Chromosome Biology! Apply until the first of Feb.
January 6, 2025 at 5:53 AM
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ksiudeja.bsky.social
To kick start the New Year, I'm delighted to share the lab's first preprint - now online:
biorxiv.org/cgi/content/...

See below for a couple of highlights👇
Any feedback is welcome!
"TEsky"

HAPPY NEW YEAR to everyone! 🥂
An endogenous retroviral element co-opts an upstream regulatory sequence to achieve somatic expression and mobility
Retrotransposons, multi-copy sequences that propagate via copy-and-paste mechanisms involving an RNA intermediate, occupy large portions of all eukaryotic genomes. A great majority of their manifold c...
biorxiv.org
January 3, 2025 at 11:15 AM
Reposted by Q-Lab
aphillippy.bsky.social
With these improvements, Verkko2 can now assemble ~40/46 diploid human chromosomes as T2T scaffolds (and ~20 as T2T contigs). This release represents a ton of work from @dantipov.bsky.social, Mikko Rautiainen, and @sergek.bsky.social Looking forward to many more T2T genomes generated in 2025! 🎆
January 2, 2025 at 3:28 PM
Reposted by Q-Lab
hendersi.bsky.social
Centrophilic retrotransposon integration via CENH3 chromatin in Arabidopsis from Tetsuji Kakutani & colleagues - beautiful insights into control of transposon insertion into the centromeres
www.nature.com/articles/s41...
Centrophilic retrotransposon integration via CENH3 chromatin in Arabidopsis - Nature
An Arabidopsis long terminal repeat retrotransposon integrates de novo into regions occupied by centromere-specific histone variant, showing the impact of centromeric chromatin on transposable element...
www.nature.com
January 2, 2025 at 5:24 PM
Reposted by Q-Lab
plantevolution.bsky.social
Announcing a curated collection of long-read genomes for Arabidopsis thaliana: The 1001 Genomes Plus Project. Currently 453 unique accessions/almost 600 assemblies.
Interested in contributing? Please contact us!
#plantscience
www.biorxiv.org/content/10.1...
December 27, 2024 at 7:51 AM