LCBM
@lcbm-epfl.bsky.social
Laboratory of Biophysical Chemistry of Macromolecules (LCBM) headed by @beatfierz.bsky.social at EPFL | Run by LCBM members
Pinned
LCBM
@lcbm-epfl.bsky.social
· May 22
Single-molecule analysis reveals the mechanism of chromatin ubiquitylation by variant PRC1 complexes
Single-molecule experiments show that active conformation formation controls chromatin ubiquitylation kinetics by variant PRC1.
www.science.org
Check out our new study of chromatin ubiquitylation. @alexateslenko.bsky.social visualized directly at single molecule scale how vPRC1 ubiquitylates neighboring nucleosomes. These results suggest potential mechanism on how H2Aub domains are established. 👇👇👇
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by LCBM
Our new study of chromatin ubiquitylation by variant PRC1 on the single-molecule scale: We visualize directly how vPRC1 ubiquitylates neighboring nucleosomes during a single binding event, showing a potential mechanism how H2Aub domains are established.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Single-molecule analysis reveals the mechanism of chromatin ubiquitylation by variant PRC1 complexes
Single-molecule experiments show that active conformation formation controls chromatin ubiquitylation kinetics by variant PRC1.
www.science.org
May 21, 2025 at 6:59 PM
Our new study of chromatin ubiquitylation by variant PRC1 on the single-molecule scale: We visualize directly how vPRC1 ubiquitylates neighboring nucleosomes during a single binding event, showing a potential mechanism how H2Aub domains are established.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by LCBM
If you always wanted to know the kinetics of how the Polycomb enzymes modify chromatin, we are thrilled to share our work!!! 🎉📄🧬🔬
Thank you, @beatfierz.bsky.social for all the guidance as well as the @lcbm-epfl.bsky.social group members for all the support!
doi.org/10.1126/scia...
Thank you, @beatfierz.bsky.social for all the guidance as well as the @lcbm-epfl.bsky.social group members for all the support!
doi.org/10.1126/scia...
Single-molecule analysis reveals the mechanism of chromatin ubiquitylation by variant PRC1 complexes
Single-molecule experiments show that active conformation formation controls chromatin ubiquitylation kinetics by variant PRC1.
doi.org
May 22, 2025 at 11:00 AM
If you always wanted to know the kinetics of how the Polycomb enzymes modify chromatin, we are thrilled to share our work!!! 🎉📄🧬🔬
Thank you, @beatfierz.bsky.social for all the guidance as well as the @lcbm-epfl.bsky.social group members for all the support!
doi.org/10.1126/scia...
Thank you, @beatfierz.bsky.social for all the guidance as well as the @lcbm-epfl.bsky.social group members for all the support!
doi.org/10.1126/scia...
Check out our new study of chromatin ubiquitylation. @alexateslenko.bsky.social visualized directly at single molecule scale how vPRC1 ubiquitylates neighboring nucleosomes. These results suggest potential mechanism on how H2Aub domains are established. 👇👇👇
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Single-molecule analysis reveals the mechanism of chromatin ubiquitylation by variant PRC1 complexes
Single-molecule experiments show that active conformation formation controls chromatin ubiquitylation kinetics by variant PRC1.
www.science.org
May 22, 2025 at 10:47 AM
Check out our new study of chromatin ubiquitylation. @alexateslenko.bsky.social visualized directly at single molecule scale how vPRC1 ubiquitylates neighboring nucleosomes. These results suggest potential mechanism on how H2Aub domains are established. 👇👇👇
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Congratulations @matteodoudin.bsky.social for this PhD fellowship 🥳🎉. Stay tuned for his next achievements about nucleosome depletion.
I am very happy to share that I was awarded a PhD fellowship from the Boehringer Ingelheim Fonds (BIF) for my project about nucleosome depletion in @lcbm-epfl.bsky.social with @beatfierz.bsky.social. Looking forward to joining the BIF community 😊🥳
May 22, 2025 at 10:39 AM
Congratulations @matteodoudin.bsky.social for this PhD fellowship 🥳🎉. Stay tuned for his next achievements about nucleosome depletion.
Reposted by LCBM
#SIRT7 is a histone deacetylase with highly specific activity on #chromatin substrates.
We just published mechanism-based #cryoEM structures of #SIRT7 on nucleosomes to understand its activity 👇
www.nature.com/articles/s41...
(1/8) #ChemBio #ChemSky
We just published mechanism-based #cryoEM structures of #SIRT7 on nucleosomes to understand its activity 👇
www.nature.com/articles/s41...
(1/8) #ChemBio #ChemSky
February 4, 2025 at 1:13 PM
#SIRT7 is a histone deacetylase with highly specific activity on #chromatin substrates.
We just published mechanism-based #cryoEM structures of #SIRT7 on nucleosomes to understand its activity 👇
www.nature.com/articles/s41...
(1/8) #ChemBio #ChemSky
We just published mechanism-based #cryoEM structures of #SIRT7 on nucleosomes to understand its activity 👇
www.nature.com/articles/s41...
(1/8) #ChemBio #ChemSky