Laoui Team @ VIB-VUB
@laouimmunology.bsky.social
Dendritic cell lovers, aiming to beat cancer
Pinned
Intratumoral delivery of lipid nanoparticle-formulated mRNA encoding IL-21, IL-7, and 4-1BBL induces systemic anti-tumor immunity
Nature Communications - Local delivery of mRNA-based immunotherapy represents an option for cancer therapy. Here the authors report that intratumoral delivery of lipid nanoparticle-formulated mRNA...
rdcu.be
Excited to share our latest work in @NatureComms
! 🎉 LNP-formulated mRNA encoding IL-21, IL-7, & 4-1BB drives systemic anti-tumor immunity—spotlight on cDC2s! 👀 Led by Ahmed Hamouda, in collaboration with @eTheRNA_engine
& @bruno_de_geest. Read here: rdcu.be/d2zQ7
! 🎉 LNP-formulated mRNA encoding IL-21, IL-7, & 4-1BB drives systemic anti-tumor immunity—spotlight on cDC2s! 👀 Led by Ahmed Hamouda, in collaboration with @eTheRNA_engine
& @bruno_de_geest. Read here: rdcu.be/d2zQ7
Last day of #THPT25 — and definitely not the least! Captivating talk by Celine Valot from the Curie Institute, spotlighting her research on how epigenomic changes in luminal cells contribute to the early onset of breast cancer. An inspiring highlight as we continue through the day!
December 12, 2025 at 9:04 AM
Last day of #THPT25 — and definitely not the least! Captivating talk by Celine Valot from the Curie Institute, spotlighting her research on how epigenomic changes in luminal cells contribute to the early onset of breast cancer. An inspiring highlight as we continue through the day!
Curious about MATRACs and their potential in cancer therapy? Check out this short video poster pitch from our PostDoc Federica at #THPT25 to learn how this emerging approach could make a difference! www.linkedin.com/feed/update/...
#thpt25 #tumorimmunology #cytokinetherapy #immunoengineering #cancerimmunity #vib #postdoclife #vibconf | VIB Training & Conferences
⚡ 𝗖𝗮𝗻 𝘄𝗲 𝗵𝗮𝗿𝗻𝗲𝘀𝘀 𝗮 𝘂𝗻𝗶𝘃𝗲𝗿𝘀𝗮𝗹 𝗳𝗲𝗮𝘁𝘂𝗿𝗲 𝗼𝗳 𝘀𝗼𝗹𝗶𝗱 𝘁𝘂𝗺𝗼𝗿𝘀 𝘁𝗼 𝗱𝗲𝗹𝗶𝘃𝗲𝗿 𝗶𝗺𝗺𝘂𝗻𝗶𝘁𝘆-𝗯𝗼𝗼𝘀𝘁𝗶𝗻𝗴 𝘀𝗶𝗴𝗻𝗮𝗹𝘀 𝗲𝘅𝗮𝗰𝘁𝗹𝘆 𝘄𝗵𝗲𝗿𝗲 𝘁𝗵𝗲𝘆’𝗿𝗲 𝗻𝗲𝗲𝗱𝗲𝗱?
To answer this, we spoke with Federica Cappellesso at #THPT25, who works in the...
www.linkedin.com
December 12, 2025 at 8:42 AM
Curious about MATRACs and their potential in cancer therapy? Check out this short video poster pitch from our PostDoc Federica at #THPT25 to learn how this emerging approach could make a difference! www.linkedin.com/feed/update/...
Always proud to see our lab so well represented at a conference! Our PhD researchers Lize and Alicia, along with Postdoc Federica, presented their work during the poster sessions. Come meet them to get the latest updates on our research at #THPT25!
December 11, 2025 at 3:52 PM
Always proud to see our lab so well represented at a conference! Our PhD researchers Lize and Alicia, along with Postdoc Federica, presented their work during the poster sessions. Come meet them to get the latest updates on our research at #THPT25!
Beautiful talk by @obenaufa.bsky.social at #THPT25 — first walking us through the key conclusions of her latest Nature paper, then offering a glimpse into the next chapter of her work unravelling the mysteries of drug tolerant persistent cells. Looking forward to see where this story goes next!
December 11, 2025 at 3:13 PM
Beautiful talk by @obenaufa.bsky.social at #THPT25 — first walking us through the key conclusions of her latest Nature paper, then offering a glimpse into the next chapter of her work unravelling the mysteries of drug tolerant persistent cells. Looking forward to see where this story goes next!
After an insightful morning focused on metastasis, we open the afternoon with a mindblowing talk of Jennifer Wargo. She discussed how microbiota can influence immunotherapy responses and the impact of fibers. To say it in her words: "The issue is in the tissue and the scoop is in the poop!" #THPT25
December 11, 2025 at 2:09 PM
After an insightful morning focused on metastasis, we open the afternoon with a mindblowing talk of Jennifer Wargo. She discussed how microbiota can influence immunotherapy responses and the impact of fibers. To say it in her words: "The issue is in the tissue and the scoop is in the poop!" #THPT25
Continuing the interesting talks at VIB #THPT25. Leanne Li discussed the heterogeneity and metabolic interplay in SCLC, showing that survival increases when blocking electrical activity in neuroendocrine cells. Great example of how fundamental insights can give rise to new therapeutic approaches!
December 10, 2025 at 2:20 PM
Continuing the interesting talks at VIB #THPT25. Leanne Li discussed the heterogeneity and metabolic interplay in SCLC, showing that survival increases when blocking electrical activity in neuroendocrine cells. Great example of how fundamental insights can give rise to new therapeutic approaches!
What an excellent way to kick of the #THPT25 conference! Keynote Johanna Joyce showed her latest insights in the complexity of the TME and talked about her promising results on preventing scar formation in brain cancer to reduce relapse and improve survival. @vibtrainconf.bsky.social
December 10, 2025 at 1:45 PM
What an excellent way to kick of the #THPT25 conference! Keynote Johanna Joyce showed her latest insights in the complexity of the TME and talked about her promising results on preventing scar formation in brain cancer to reduce relapse and improve survival. @vibtrainconf.bsky.social
The Tumor Heterogeneity, Plasticity and Therapy Conference #THPT25 is almost here!⏰Registration closes Nov 26th vibbio.tech/THPT25. Don't miss this chance to hear more from Leanne Li (The Francis Crick Institute, UK) who focuses on combining cancer biology and neuroscience @leanneli.bsky.social
November 19, 2025 at 1:05 PM
The Tumor Heterogeneity, Plasticity and Therapy Conference #THPT25 is almost here!⏰Registration closes Nov 26th vibbio.tech/THPT25. Don't miss this chance to hear more from Leanne Li (The Francis Crick Institute, UK) who focuses on combining cancer biology and neuroscience @leanneli.bsky.social
🎯 New speaker alert: Jennifer Wargo (MD Anderson Cancer Center, US) will share cutting-edge advances in precision, genetically targeted cancer therapies at the THPT Conference.
📍 Leuven | 🗓️ 10–12 Dec | #THPT25
🔗 Early bird registration deadline: 29 October vibbio.tech/THPT25
📍 Leuven | 🗓️ 10–12 Dec | #THPT25
🔗 Early bird registration deadline: 29 October vibbio.tech/THPT25
October 22, 2025 at 2:55 PM
🎯 New speaker alert: Jennifer Wargo (MD Anderson Cancer Center, US) will share cutting-edge advances in precision, genetically targeted cancer therapies at the THPT Conference.
📍 Leuven | 🗓️ 10–12 Dec | #THPT25
🔗 Early bird registration deadline: 29 October vibbio.tech/THPT25
📍 Leuven | 🗓️ 10–12 Dec | #THPT25
🔗 Early bird registration deadline: 29 October vibbio.tech/THPT25
The Tumor Heterogeneity, Plasticity & Therapy Conference welcomes Céline Vallot (@institutcurie.bsky.social) to share her research on epigenomic evolution of breast cancers at single-cell resolution.
📍 Leuven | 📅 10–12 Dec | #THPT25
⏳ Early bird registration deadline: 29 October vibbio.tech/THPT25
📍 Leuven | 📅 10–12 Dec | #THPT25
⏳ Early bird registration deadline: 29 October vibbio.tech/THPT25
October 11, 2025 at 9:09 AM
The Tumor Heterogeneity, Plasticity & Therapy Conference welcomes Céline Vallot (@institutcurie.bsky.social) to share her research on epigenomic evolution of breast cancers at single-cell resolution.
📍 Leuven | 📅 10–12 Dec | #THPT25
⏳ Early bird registration deadline: 29 October vibbio.tech/THPT25
📍 Leuven | 📅 10–12 Dec | #THPT25
⏳ Early bird registration deadline: 29 October vibbio.tech/THPT25
🎉 Not 1, but 2 prizes! Huge congrats to our team members for their outstanding achievements at the 7th Research Day on Tumor Immunology and Immunotherapy!
🏆 Alicia Gordun Pero–Poster Prize
🎤 Pauline Bardet–Selected Talk Prize
We’re proud to see their hard work and research being recognized 👏
🏆 Alicia Gordun Pero–Poster Prize
🎤 Pauline Bardet–Selected Talk Prize
We’re proud to see their hard work and research being recognized 👏
October 11, 2025 at 9:05 AM
🎉 Not 1, but 2 prizes! Huge congrats to our team members for their outstanding achievements at the 7th Research Day on Tumor Immunology and Immunotherapy!
🏆 Alicia Gordun Pero–Poster Prize
🎤 Pauline Bardet–Selected Talk Prize
We’re proud to see their hard work and research being recognized 👏
🏆 Alicia Gordun Pero–Poster Prize
🎤 Pauline Bardet–Selected Talk Prize
We’re proud to see their hard work and research being recognized 👏
At the Tumor Heterogeneity, Plasticity and Therapy Conference (#THPT25) in Leuven from 10–12 December, Eduard Batlle from IRB Barcelona will show how the tumor microenvironment can facilitate immune evasion and metastasis.
Abstract deadline: 8th of October
vibbio.tech/THPT25
Abstract deadline: 8th of October
vibbio.tech/THPT25
October 7, 2025 at 12:33 PM
At the Tumor Heterogeneity, Plasticity and Therapy Conference (#THPT25) in Leuven from 10–12 December, Eduard Batlle from IRB Barcelona will show how the tumor microenvironment can facilitate immune evasion and metastasis.
Abstract deadline: 8th of October
vibbio.tech/THPT25
Abstract deadline: 8th of October
vibbio.tech/THPT25
The Laoui Lab will be well represented at the Tumor Heterogeneity, Plasticity and Therapy (3rd edition) conference #THPT25! Join us to hear more about therapy resistence in #cancer from Anna Obenauf
@obenaufa.bsky.social
Submit your abstract by the 8th of October on vibbio.tech/THPT25
@obenaufa.bsky.social
Submit your abstract by the 8th of October on vibbio.tech/THPT25
October 7, 2025 at 12:27 PM
The Laoui Lab will be well represented at the Tumor Heterogeneity, Plasticity and Therapy (3rd edition) conference #THPT25! Join us to hear more about therapy resistence in #cancer from Anna Obenauf
@obenaufa.bsky.social
Submit your abstract by the 8th of October on vibbio.tech/THPT25
@obenaufa.bsky.social
Submit your abstract by the 8th of October on vibbio.tech/THPT25
🚨 New publication!
In a collaborative effort led by Etherna, we reveal how two optimized LNPs trigger distinct IgG2a vs IgG1 phenotypes.
This opens the door to tuning LNP design for tailored immune responses in mRNA vaccines & beyond.
advanced.onlinelibrary.wiley.com/doi/10.1002/...
In a collaborative effort led by Etherna, we reveal how two optimized LNPs trigger distinct IgG2a vs IgG1 phenotypes.
This opens the door to tuning LNP design for tailored immune responses in mRNA vaccines & beyond.
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models
Structure–activity relationship (SAR) optimization of bio-reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolera...
advanced.onlinelibrary.wiley.com
September 23, 2025 at 6:47 PM
🚨 New publication!
In a collaborative effort led by Etherna, we reveal how two optimized LNPs trigger distinct IgG2a vs IgG1 phenotypes.
This opens the door to tuning LNP design for tailored immune responses in mRNA vaccines & beyond.
advanced.onlinelibrary.wiley.com/doi/10.1002/...
In a collaborative effort led by Etherna, we reveal how two optimized LNPs trigger distinct IgG2a vs IgG1 phenotypes.
This opens the door to tuning LNP design for tailored immune responses in mRNA vaccines & beyond.
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Watching students grow into independent scientists is the best part of this job. Huge congrats to my first PhD student @matekiss.bsky.social stating his onw lab!
Happy to share that I’ll be starting my lab as a junior group leader at the Georg-Speyer-Haus in Frankfurt in 2026. We’ll study how transcriptional regulators control neutrophil function in cancer. I’ll be hiring soon (PhD/lab tech), please reach out if you know someone interested!
August 3, 2025 at 6:51 AM
Watching students grow into independent scientists is the best part of this job. Huge congrats to my first PhD student @matekiss.bsky.social stating his onw lab!
Reposted by Laoui Team @ VIB-VUB
Our new paper is out:
Tumors don’t just reprogram monocytes locally. We show in a mouse model that the systemic impact of a tumor can alter the epigenome of peripheral monocytes, repressing IFN-responsive regulatory elements and priming pro-tumor gene programs.
Tumors don’t just reprogram monocytes locally. We show in a mouse model that the systemic impact of a tumor can alter the epigenome of peripheral monocytes, repressing IFN-responsive regulatory elements and priming pro-tumor gene programs.
Epigenomic preconditioning of peripheral monocytes determines their transcriptional response to the tumor microenvironment - Genome Medicine
Background Monocytes are recruited to tumors and undergo transcriptional reprogramming resulting in tumor-promoting functions. Epigenomic features, such as post-translational modification of histones ...
genomemedicine.biomedcentral.com
July 30, 2025 at 8:17 AM
Our new paper is out:
Tumors don’t just reprogram monocytes locally. We show in a mouse model that the systemic impact of a tumor can alter the epigenome of peripheral monocytes, repressing IFN-responsive regulatory elements and priming pro-tumor gene programs.
Tumors don’t just reprogram monocytes locally. We show in a mouse model that the systemic impact of a tumor can alter the epigenome of peripheral monocytes, repressing IFN-responsive regulatory elements and priming pro-tumor gene programs.
Reposted by Laoui Team @ VIB-VUB
I am grateful to co-lead authors Laszlo Halasz and Eva Hadadi, and everyone involved from the labs of Jo Van Ginderachter, Laszlo Nagy, and Damya Laoui (@laouimmunology.bsky.social).
July 30, 2025 at 8:17 AM
I am grateful to co-lead authors Laszlo Halasz and Eva Hadadi, and everyone involved from the labs of Jo Van Ginderachter, Laszlo Nagy, and Damya Laoui (@laouimmunology.bsky.social).
Day 3 at #INCI25
@movahedilab.bsky.social presented some fantastic images of brain immune niches as well as their recently published work in @cp-immunity.bsky.social on microglia replacement therapy. After the break, Christoph Scheiermann reminded us how much our day-night cycle impact immunity
@movahedilab.bsky.social presented some fantastic images of brain immune niches as well as their recently published work in @cp-immunity.bsky.social on microglia replacement therapy. After the break, Christoph Scheiermann reminded us how much our day-night cycle impact immunity
May 9, 2025 at 10:27 AM
Day 3 at #INCI25
@movahedilab.bsky.social presented some fantastic images of brain immune niches as well as their recently published work in @cp-immunity.bsky.social on microglia replacement therapy. After the break, Christoph Scheiermann reminded us how much our day-night cycle impact immunity
@movahedilab.bsky.social presented some fantastic images of brain immune niches as well as their recently published work in @cp-immunity.bsky.social on microglia replacement therapy. After the break, Christoph Scheiermann reminded us how much our day-night cycle impact immunity
Last presenter of the day at #INCI25, Michele De Palma presented some impressive results exploiting cytokine-armed dendritic cell progenitors as cancer therapy in anti-PD1 refractory lung cancer.
Now up to enjoy our boat tour in the beautiful Bruges and socialize with our fellow-scientists!
Now up to enjoy our boat tour in the beautiful Bruges and socialize with our fellow-scientists!
May 8, 2025 at 5:01 PM
Last presenter of the day at #INCI25, Michele De Palma presented some impressive results exploiting cytokine-armed dendritic cell progenitors as cancer therapy in anti-PD1 refractory lung cancer.
Now up to enjoy our boat tour in the beautiful Bruges and socialize with our fellow-scientists!
Now up to enjoy our boat tour in the beautiful Bruges and socialize with our fellow-scientists!
We finish the Cell Therapy session at #INCI25 with two top speakers. First, Tobias Weiss provided an overview of the next-generation therapies for glioblastoma from antibody-cytokine fusion proteins to cytokine-expressing CAR-T cells and exploiting macrophages as drug delivery platform.
May 8, 2025 at 3:23 PM
We finish the Cell Therapy session at #INCI25 with two top speakers. First, Tobias Weiss provided an overview of the next-generation therapies for glioblastoma from antibody-cytokine fusion proteins to cytokine-expressing CAR-T cells and exploiting macrophages as drug delivery platform.
After presenting my poster at #INCI25 about the potential of CD40 agonist to enhance anti tumor immunity of tumor-derived cDCs, the session started with an excellent talk by Gabriele Bergers about the key role of the diva’s of endothelial cells, the high endothelial venules in anti-tumor immunity!
May 8, 2025 at 1:16 PM
After presenting my poster at #INCI25 about the potential of CD40 agonist to enhance anti tumor immunity of tumor-derived cDCs, the session started with an excellent talk by Gabriele Bergers about the key role of the diva’s of endothelial cells, the high endothelial venules in anti-tumor immunity!
Day 2 at #INCI25 started with a great neuro-immuno crosstalk session.
As selected abstract, VIB Alumni Ilaria Decimo showed us her exciting work uncovering that TAMs can promote neuronal growth and can be exploited to restore functional motor recovery in a mouse model of spinal cord injury!
As selected abstract, VIB Alumni Ilaria Decimo showed us her exciting work uncovering that TAMs can promote neuronal growth and can be exploited to restore functional motor recovery in a mouse model of spinal cord injury!
May 8, 2025 at 8:52 AM
Day 2 at #INCI25 started with a great neuro-immuno crosstalk session.
As selected abstract, VIB Alumni Ilaria Decimo showed us her exciting work uncovering that TAMs can promote neuronal growth and can be exploited to restore functional motor recovery in a mouse model of spinal cord injury!
As selected abstract, VIB Alumni Ilaria Decimo showed us her exciting work uncovering that TAMs can promote neuronal growth and can be exploited to restore functional motor recovery in a mouse model of spinal cord injury!
Another great talk by Pablo Vargas @leukomotion.bsky.social at #INCI25!
His strategy, question the lack of hereditary immunodeficiencies linked to leukocyte motility! The DNA damage protein ATM came out as unexpected candidate with ATM inhibition reducing leukocyte motility in 3D matrices
His strategy, question the lack of hereditary immunodeficiencies linked to leukocyte motility! The DNA damage protein ATM came out as unexpected candidate with ATM inhibition reducing leukocyte motility in 3D matrices
May 7, 2025 at 2:07 PM
Another great talk by Pablo Vargas @leukomotion.bsky.social at #INCI25!
His strategy, question the lack of hereditary immunodeficiencies linked to leukocyte motility! The DNA damage protein ATM came out as unexpected candidate with ATM inhibition reducing leukocyte motility in 3D matrices
His strategy, question the lack of hereditary immunodeficiencies linked to leukocyte motility! The DNA damage protein ATM came out as unexpected candidate with ATM inhibition reducing leukocyte motility in 3D matrices
After some lunch and the first poster session, we are ready for the afternoon session with my fellow conference reporters to report back on the most interesting talks at #INCI25.
So follow @tommasoscolaro.bsky.social and @vibtrainconf.bsky.social to learn about the newest hot topics!
So follow @tommasoscolaro.bsky.social and @vibtrainconf.bsky.social to learn about the newest hot topics!
May 7, 2025 at 12:38 PM
After some lunch and the first poster session, we are ready for the afternoon session with my fellow conference reporters to report back on the most interesting talks at #INCI25.
So follow @tommasoscolaro.bsky.social and @vibtrainconf.bsky.social to learn about the newest hot topics!
So follow @tommasoscolaro.bsky.social and @vibtrainconf.bsky.social to learn about the newest hot topics!
We finished our first extremely interesting morning session at #INCI25!
As selected abstract, @gretamattavelli.bsky.social from the @riedel-lab.bsky.social was the last to present her PhD work on the role of lymph nodes in metastasis formation before the break!
As selected abstract, @gretamattavelli.bsky.social from the @riedel-lab.bsky.social was the last to present her PhD work on the role of lymph nodes in metastasis formation before the break!
May 7, 2025 at 9:42 AM
We finished our first extremely interesting morning session at #INCI25!
As selected abstract, @gretamattavelli.bsky.social from the @riedel-lab.bsky.social was the last to present her PhD work on the role of lymph nodes in metastasis formation before the break!
As selected abstract, @gretamattavelli.bsky.social from the @riedel-lab.bsky.social was the last to present her PhD work on the role of lymph nodes in metastasis formation before the break!