Vanni Lab at UNIFR, Switzerland
@labvanni.bsky.social
Computational biophysics and other amenities...
"More thinking and less pipetting"
"More thinking and less pipetting"
Happy to share the latest from the lab, led by Daniel Alvarez, in collaboration with @lizconibear.bsky.social. In this AA-MD tour-de-force, we delve deep into the mechanism and energetics of lipid uptake by bridge-like lipid transfer proteins, and we learn a few interesting things along the way...
August 7, 2025 at 8:45 AM
Happy to share the latest from the lab, led by Daniel Alvarez, in collaboration with @lizconibear.bsky.social. In this AA-MD tour-de-force, we delve deep into the mechanism and energetics of lipid uptake by bridge-like lipid transfer proteins, and we learn a few interesting things along the way...
We also modelled Brl1 in curved membranes (a vesicle mimicking the INM shape). Same result: Brl1/Brr6 oligomers stably interacting and promoting lipid mixing within the channel. (11/13)
July 23, 2025 at 11:53 AM
We also modelled Brl1 in curved membranes (a vesicle mimicking the INM shape). Same result: Brl1/Brr6 oligomers stably interacting and promoting lipid mixing within the channel. (11/13)
We went back to simulations of opposed bilayers, but with protein oligomers in both of them. We observed a gradual decrease in membrane distances to the point of interaction between proteins (Brl1 and Brr6). This interaction results in lipid mixing in the central channel of the rings. (8/13)
July 23, 2025 at 11:50 AM
We went back to simulations of opposed bilayers, but with protein oligomers in both of them. We observed a gradual decrease in membrane distances to the point of interaction between proteins (Brl1 and Brr6). This interaction results in lipid mixing in the central channel of the rings. (8/13)
Happy to share the latest work from the lab, led by @mudgal17.bsky.social, in collaboration with the Weis lab @ethzurich.bsky.social.
How do nuclear membranes fuse during NPC assembly? We answer this question in our latest work, where we identify a new mechanism for membrane fusion… (1/13)
How do nuclear membranes fuse during NPC assembly? We answer this question in our latest work, where we identify a new mechanism for membrane fusion… (1/13)
July 23, 2025 at 11:40 AM
Happy to share the latest work from the lab, led by @mudgal17.bsky.social, in collaboration with the Weis lab @ethzurich.bsky.social.
How do nuclear membranes fuse during NPC assembly? We answer this question in our latest work, where we identify a new mechanism for membrane fusion… (1/13)
How do nuclear membranes fuse during NPC assembly? We answer this question in our latest work, where we identify a new mechanism for membrane fusion… (1/13)