LaBella Lab
@lablabella.bsky.social
LaBella Lab studies codon usage (aka "silent" genetic changes) and evolution from humans to fungi | Bioinformatics & Genomics | UNC Charlotte
Run by Abbe LaBella
Opinions are my own and do not reflect any affiliated organization.
Run by Abbe LaBella
Opinions are my own and do not reflect any affiliated organization.
Come celebrate 50 years of the GRC Cellular and Molecular Fungal Biology series!!
www.grc.org/cellular-and...
www.grc.org/cellular-and...
November 17, 2025 at 7:28 PM
Come celebrate 50 years of the GRC Cellular and Molecular Fungal Biology series!!
www.grc.org/cellular-and...
www.grc.org/cellular-and...
Mini @rokaslab.bsky.social reunion with Dr. Abigail Lind @abigailllind.bsky.social
Amazing seminar... What is in our gut and what is it doing!?
I assume our students are flocking to try EukDetect!
Amazing seminar... What is in our gut and what is it doing!?
I assume our students are flocking to try EukDetect!
November 7, 2025 at 7:40 PM
Mini @rokaslab.bsky.social reunion with Dr. Abigail Lind @abigailllind.bsky.social
Amazing seminar... What is in our gut and what is it doing!?
I assume our students are flocking to try EukDetect!
Amazing seminar... What is in our gut and what is it doing!?
I assume our students are flocking to try EukDetect!
Dr. White @raw937.bsky.social discusses bats 🦇 and viruses at the Biomedical Symposium
September 15, 2025 at 5:17 PM
Dr. White @raw937.bsky.social discusses bats 🦇 and viruses at the Biomedical Symposium
Brad Bower of the NIH outlines the Strategic Plan for Data Science
Do you share your data in a usable way?
Where can AI take us next?
Do you share your data in a usable way?
Where can AI take us next?
September 15, 2025 at 2:43 PM
Brad Bower of the NIH outlines the Strategic Plan for Data Science
Do you share your data in a usable way?
Where can AI take us next?
Do you share your data in a usable way?
Where can AI take us next?
Excited for the Charlotte Biomedical Symposium today!
Intro to CIPHER by Dr. Jamie's featuring a @morgancarterphd.bsky.social Carter lab trainee
Intro to CIPHER by Dr. Jamie's featuring a @morgancarterphd.bsky.social Carter lab trainee
September 15, 2025 at 1:40 PM
Excited for the Charlotte Biomedical Symposium today!
Intro to CIPHER by Dr. Jamie's featuring a @morgancarterphd.bsky.social Carter lab trainee
Intro to CIPHER by Dr. Jamie's featuring a @morgancarterphd.bsky.social Carter lab trainee
Ew... @theathletic.com
Do I "remember" the great Ilona Maher?!
I never forgot about her. She's been kicking ass this whole time!
Do better... not all your readers instantly forget about half of all athletes because of their gender
Do I "remember" the great Ilona Maher?!
I never forgot about her. She's been kicking ass this whole time!
Do better... not all your readers instantly forget about half of all athletes because of their gender
August 21, 2025 at 11:56 AM
Ew... @theathletic.com
Do I "remember" the great Ilona Maher?!
I never forgot about her. She's been kicking ass this whole time!
Do better... not all your readers instantly forget about half of all athletes because of their gender
Do I "remember" the great Ilona Maher?!
I never forgot about her. She's been kicking ass this whole time!
Do better... not all your readers instantly forget about half of all athletes because of their gender
Amazing work from Dr. Anne Hatmaker @annemakerofhats.bsky.social at @canfunnet.bsky.social #CFN25
She takes us on a deep dive into the diversity of Penicillium isolates from diverse habitats
She takes us on a deep dive into the diversity of Penicillium isolates from diverse habitats
August 6, 2025 at 8:06 PM
Amazing work from Dr. Anne Hatmaker @annemakerofhats.bsky.social at @canfunnet.bsky.social #CFN25
She takes us on a deep dive into the diversity of Penicillium isolates from diverse habitats
She takes us on a deep dive into the diversity of Penicillium isolates from diverse habitats
Excited to tune into the CanFunNet meeting! @canfunnet.bsky.social
Check out our trainee Isha Jain's presentation on Friday in the Fungal Genetics & Genomics VI starting at 3:50pm
#CFN25
Great introduction to CanFunNet with Dr. Horianopoulos @linder-surprise.bsky.social
Check out our trainee Isha Jain's presentation on Friday in the Fungal Genetics & Genomics VI starting at 3:50pm
#CFN25
Great introduction to CanFunNet with Dr. Horianopoulos @linder-surprise.bsky.social
August 6, 2025 at 3:23 PM
Excited to tune into the CanFunNet meeting! @canfunnet.bsky.social
Check out our trainee Isha Jain's presentation on Friday in the Fungal Genetics & Genomics VI starting at 3:50pm
#CFN25
Great introduction to CanFunNet with Dr. Horianopoulos @linder-surprise.bsky.social
Check out our trainee Isha Jain's presentation on Friday in the Fungal Genetics & Genomics VI starting at 3:50pm
#CFN25
Great introduction to CanFunNet with Dr. Horianopoulos @linder-surprise.bsky.social
Ameya Jalihal of the @gladfelterlab.bsky.social asks how you maintain asynchrony in nuclear division?
Well... The cell isn't a free for all diffusion. Cellular condensates are critical to nuclear division asynchrony
Read more here: pmc.ncbi.nlm.nih.gov/articles/PMC...
Well... The cell isn't a free for all diffusion. Cellular condensates are critical to nuclear division asynchrony
Read more here: pmc.ncbi.nlm.nih.gov/articles/PMC...
July 28, 2025 at 7:44 PM
Ameya Jalihal of the @gladfelterlab.bsky.social asks how you maintain asynchrony in nuclear division?
Well... The cell isn't a free for all diffusion. Cellular condensates are critical to nuclear division asynchrony
Read more here: pmc.ncbi.nlm.nih.gov/articles/PMC...
Well... The cell isn't a free for all diffusion. Cellular condensates are critical to nuclear division asynchrony
Read more here: pmc.ncbi.nlm.nih.gov/articles/PMC...
Audrey Williams of the @gladfelterlab.bsky.social uses GEMs 💎 to understand how the fungus A. pullulens can deal with incredibly high salt 🧂 concentrations
July 28, 2025 at 4:32 PM
Audrey Williams of the @gladfelterlab.bsky.social uses GEMs 💎 to understand how the fungus A. pullulens can deal with incredibly high salt 🧂 concentrations
@mycorican.bsky.social presents at the Tri-I symposium at Duke.
He begins by encouraging us to be more like Aspergillus... Resilient and adaptable
He begins by encouraging us to be more like Aspergillus... Resilient and adaptable
July 28, 2025 at 2:29 PM
@mycorican.bsky.social presents at the Tri-I symposium at Duke.
He begins by encouraging us to be more like Aspergillus... Resilient and adaptable
He begins by encouraging us to be more like Aspergillus... Resilient and adaptable
Woods Hole holds such a special place in my life and career.
WHOi summer program
Taking ALVIN home
Guest lecture at the MBL physiology course
@mblscience.bsky.social
Can't wait to come back!
WHOi summer program
Taking ALVIN home
Guest lecture at the MBL physiology course
@mblscience.bsky.social
Can't wait to come back!
July 24, 2025 at 2:40 PM
Woods Hole holds such a special place in my life and career.
WHOi summer program
Taking ALVIN home
Guest lecture at the MBL physiology course
@mblscience.bsky.social
Can't wait to come back!
WHOi summer program
Taking ALVIN home
Guest lecture at the MBL physiology course
@mblscience.bsky.social
Can't wait to come back!
Menna Jones @mennajones.bsky.social describes a multi-regime bounded Brownian motion model
This model is assessed in frogs 🐸 to show that there may be shifts in developmental constraints
#Evol2025 #Evol25
This model is assessed in frogs 🐸 to show that there may be shifts in developmental constraints
#Evol2025 #Evol25
June 24, 2025 at 8:25 PM
Menna Jones @mennajones.bsky.social describes a multi-regime bounded Brownian motion model
This model is assessed in frogs 🐸 to show that there may be shifts in developmental constraints
#Evol2025 #Evol25
This model is assessed in frogs 🐸 to show that there may be shifts in developmental constraints
#Evol2025 #Evol25
Kyle David @kylethedavid.bsky.social discusses two new genome 🧬 duplications 🧬🧬 in the yeast subphylum
With three WGD clades, we can ask what are the causes and consequences of WGD in yeast
@evolutionvu.bsky.social @rokaslab.bsky.social
#Evol2025 #Evol24
With three WGD clades, we can ask what are the causes and consequences of WGD in yeast
@evolutionvu.bsky.social @rokaslab.bsky.social
#Evol2025 #Evol24
June 24, 2025 at 6:52 PM
Kyle David @kylethedavid.bsky.social discusses two new genome 🧬 duplications 🧬🧬 in the yeast subphylum
With three WGD clades, we can ask what are the causes and consequences of WGD in yeast
@evolutionvu.bsky.social @rokaslab.bsky.social
#Evol2025 #Evol24
With three WGD clades, we can ask what are the causes and consequences of WGD in yeast
@evolutionvu.bsky.social @rokaslab.bsky.social
#Evol2025 #Evol24
Not accounting for codon evolution?
You may end up with large amounts of false positives in tests for selection!
academic.oup.com/mbe/article/...
#Evol2025 #Evol25
You may end up with large amounts of false positives in tests for selection!
academic.oup.com/mbe/article/...
#Evol2025 #Evol25
June 24, 2025 at 6:43 PM
Not accounting for codon evolution?
You may end up with large amounts of false positives in tests for selection!
academic.oup.com/mbe/article/...
#Evol2025 #Evol25
You may end up with large amounts of false positives in tests for selection!
academic.oup.com/mbe/article/...
#Evol2025 #Evol25
Hannah Verdonk @hverdonk.bsky.social describes Multiclass Synonymous Substitution (MSS) models
This model helps us avoid the trap of assuming all synonymous substitutions are created equal
The method captures selection on tRNA abundance
#Evol2025 #Evol25
This model helps us avoid the trap of assuming all synonymous substitutions are created equal
The method captures selection on tRNA abundance
#Evol2025 #Evol25
June 24, 2025 at 6:38 PM
Hannah Verdonk @hverdonk.bsky.social describes Multiclass Synonymous Substitution (MSS) models
This model helps us avoid the trap of assuming all synonymous substitutions are created equal
The method captures selection on tRNA abundance
#Evol2025 #Evol25
This model helps us avoid the trap of assuming all synonymous substitutions are created equal
The method captures selection on tRNA abundance
#Evol2025 #Evol25
Russell Dinnage @rdinnager.bsky.social proposes that Evolutionary Constraints present a challenge & opportunity to build better models
GenAI can learn the underlying constraints of evolution w/out proposing impossible states
Work in bird beaks 🐦🐤🦆🪿🐦⬛ demonstrates the possibilities!
#Evol2025
GenAI can learn the underlying constraints of evolution w/out proposing impossible states
Work in bird beaks 🐦🐤🦆🪿🐦⬛ demonstrates the possibilities!
#Evol2025
June 24, 2025 at 4:23 PM
Russell Dinnage @rdinnager.bsky.social proposes that Evolutionary Constraints present a challenge & opportunity to build better models
GenAI can learn the underlying constraints of evolution w/out proposing impossible states
Work in bird beaks 🐦🐤🦆🪿🐦⬛ demonstrates the possibilities!
#Evol2025
GenAI can learn the underlying constraints of evolution w/out proposing impossible states
Work in bird beaks 🐦🐤🦆🪿🐦⬛ demonstrates the possibilities!
#Evol2025
Alberto Rivera of the Baxevanis group @baxevanislab.bsky.social presents on the allorecognition in cnidarians 🪸
There is evidence for synteny and conservation across allorecognition complexes in Cnidaria... How does this compare to bilaterians?
#Evol2025 #Evol25
There is evidence for synteny and conservation across allorecognition complexes in Cnidaria... How does this compare to bilaterians?
#Evol2025 #Evol25
June 24, 2025 at 4:14 PM
Alberto Rivera of the Baxevanis group @baxevanislab.bsky.social presents on the allorecognition in cnidarians 🪸
There is evidence for synteny and conservation across allorecognition complexes in Cnidaria... How does this compare to bilaterians?
#Evol2025 #Evol25
There is evidence for synteny and conservation across allorecognition complexes in Cnidaria... How does this compare to bilaterians?
#Evol2025 #Evol25
Ryan York of @arcadiascience.com discusses Biological Foundation Models
These models aim to soak up all biological data and spit out biological understanding
The models, however, are hitting a plateau
More parameters != More information
#Evol2025 #Evol25
These models aim to soak up all biological data and spit out biological understanding
The models, however, are hitting a plateau
More parameters != More information
#Evol2025 #Evol25
June 24, 2025 at 3:52 PM
Ryan York of @arcadiascience.com discusses Biological Foundation Models
These models aim to soak up all biological data and spit out biological understanding
The models, however, are hitting a plateau
More parameters != More information
#Evol2025 #Evol25
These models aim to soak up all biological data and spit out biological understanding
The models, however, are hitting a plateau
More parameters != More information
#Evol2025 #Evol25
Lei Curtis @leicurtis.bsky.social explores the role of inversions 🧬↔️🧬 in the Atlantic Cod 🐟
They combine results from multiple methods to identify the most likely inversions give within and between method variation
Small inversions happen! And they are common.
#Evol2025 #Evol25
They combine results from multiple methods to identify the most likely inversions give within and between method variation
Small inversions happen! And they are common.
#Evol2025 #Evol25
June 24, 2025 at 3:40 PM
Lei Curtis @leicurtis.bsky.social explores the role of inversions 🧬↔️🧬 in the Atlantic Cod 🐟
They combine results from multiple methods to identify the most likely inversions give within and between method variation
Small inversions happen! And they are common.
#Evol2025 #Evol25
They combine results from multiple methods to identify the most likely inversions give within and between method variation
Small inversions happen! And they are common.
#Evol2025 #Evol25
James Boyko @jboyko.bsky.social reminds us that comparative methods for trait evolution are highly dependent on model choice
He proposed new ideas for searching and optimizing model choice
#Evol2025 #Evol25
He proposed new ideas for searching and optimizing model choice
#Evol2025 #Evol25
June 24, 2025 at 3:14 PM
James Boyko @jboyko.bsky.social reminds us that comparative methods for trait evolution are highly dependent on model choice
He proposed new ideas for searching and optimizing model choice
#Evol2025 #Evol25
He proposed new ideas for searching and optimizing model choice
#Evol2025 #Evol25
Olivia Brooks @olbrooks.bsky.social shares the evolution of autoresistance to toxins in amphibians 🐸
Sodium channels from 39 amphibians revealed some fascinating evidence for gene conversion
#Evol2025 #Evol25
Sodium channels from 39 amphibians revealed some fascinating evidence for gene conversion
#Evol2025 #Evol25
June 24, 2025 at 2:13 PM
Olivia Brooks @olbrooks.bsky.social shares the evolution of autoresistance to toxins in amphibians 🐸
Sodium channels from 39 amphibians revealed some fascinating evidence for gene conversion
#Evol2025 #Evol25
Sodium channels from 39 amphibians revealed some fascinating evidence for gene conversion
#Evol2025 #Evol25
Megan Phillips @meganphillips.bsky.social tells the tale of the little plasmid 🧬 that could 🦠
How does antimicrobial resistance impact the evolution of plasmids
#Evol2025 #Evol25
How does antimicrobial resistance impact the evolution of plasmids
#Evol2025 #Evol25
June 24, 2025 at 1:49 PM
Megan Phillips @meganphillips.bsky.social tells the tale of the little plasmid 🧬 that could 🦠
How does antimicrobial resistance impact the evolution of plasmids
#Evol2025 #Evol25
How does antimicrobial resistance impact the evolution of plasmids
#Evol2025 #Evol25
Michael Catto @mcatto1.bsky.social kicks off our final day of #Evol2025 #Evol25 by asking if different phenotypes have different trait optimum.
251 expression 🧬 sets from yellow jackets 🐝 finds that gene expression is constrained across castes 👑 and tissues 🧠
251 expression 🧬 sets from yellow jackets 🐝 finds that gene expression is constrained across castes 👑 and tissues 🧠
June 24, 2025 at 1:42 PM
Michael Catto @mcatto1.bsky.social kicks off our final day of #Evol2025 #Evol25 by asking if different phenotypes have different trait optimum.
251 expression 🧬 sets from yellow jackets 🐝 finds that gene expression is constrained across castes 👑 and tissues 🧠
251 expression 🧬 sets from yellow jackets 🐝 finds that gene expression is constrained across castes 👑 and tissues 🧠