INOUE lab. (ISSP, Univ. Tokyo)
@labinoue.bsky.social
Our new study on novel carotenoid-binding rhodopsins from Antarctic bacteria 🏔️🦠is now published in Commun. Biol.!🥳
This protein helps capture weak light in extreme environments. Interestingly, cyanobacteria also possess it. ✨
www.nature.com/articles/s42...
@commsbio.nature.com #OpenAccess
This protein helps capture weak light in extreme environments. Interestingly, cyanobacteria also possess it. ✨
www.nature.com/articles/s42...
@commsbio.nature.com #OpenAccess
November 30, 2025 at 7:07 AM
Our new study on novel carotenoid-binding rhodopsins from Antarctic bacteria 🏔️🦠is now published in Commun. Biol.!🥳
This protein helps capture weak light in extreme environments. Interestingly, cyanobacteria also possess it. ✨
www.nature.com/articles/s42...
@commsbio.nature.com #OpenAccess
This protein helps capture weak light in extreme environments. Interestingly, cyanobacteria also possess it. ✨
www.nature.com/articles/s42...
@commsbio.nature.com #OpenAccess
600 nm以上と、あらゆる動物において最も長波長に吸収を持つ分子を含む、シャコのロドプシンに関するPeter Hegemann先生らのご研究🦐😳
Mantis shrimp rhodopsins, including the most red-shifted ones beyond 600 nm, by Peter and his colleagues!🦐😳
biorxiv.org/content/10.1...
@biorxivpreprint.bsky.social
Mantis shrimp rhodopsins, including the most red-shifted ones beyond 600 nm, by Peter and his colleagues!🦐😳
biorxiv.org/content/10.1...
@biorxivpreprint.bsky.social
November 29, 2025 at 12:10 PM
600 nm以上と、あらゆる動物において最も長波長に吸収を持つ分子を含む、シャコのロドプシンに関するPeter Hegemann先生らのご研究🦐😳
Mantis shrimp rhodopsins, including the most red-shifted ones beyond 600 nm, by Peter and his colleagues!🦐😳
biorxiv.org/content/10.1...
@biorxivpreprint.bsky.social
Mantis shrimp rhodopsins, including the most red-shifted ones beyond 600 nm, by Peter and his colleagues!🦐😳
biorxiv.org/content/10.1...
@biorxivpreprint.bsky.social
ロドプシングアニル酸シクラーゼと改変型 cGMP作動性 K⁺ チャネルを用いた神経抑制型オプトジェネティクス🌟
Optogenetic silencing using rhodopsin-GC and engineered cGMP-gated K+ channels🌟
www.science.org/doi/10.1126/...
@johvierock.bsky.social #OpenAccess
Optogenetic silencing using rhodopsin-GC and engineered cGMP-gated K+ channels🌟
www.science.org/doi/10.1126/...
@johvierock.bsky.social #OpenAccess
November 29, 2025 at 7:14 AM
ロドプシングアニル酸シクラーゼと改変型 cGMP作動性 K⁺ チャネルを用いた神経抑制型オプトジェネティクス🌟
Optogenetic silencing using rhodopsin-GC and engineered cGMP-gated K+ channels🌟
www.science.org/doi/10.1126/...
@johvierock.bsky.social #OpenAccess
Optogenetic silencing using rhodopsin-GC and engineered cGMP-gated K+ channels🌟
www.science.org/doi/10.1126/...
@johvierock.bsky.social #OpenAccess
Sensing a rainbow of colors: algal photoreceptors🦠The diversity of microalgae and their rhodopsins🧬
frontiersin.org/journals/pla...
#OpenAccess
frontiersin.org/journals/pla...
#OpenAccess
November 10, 2025 at 12:31 AM
Sensing a rainbow of colors: algal photoreceptors🦠The diversity of microalgae and their rhodopsins🧬
frontiersin.org/journals/pla...
#OpenAccess
frontiersin.org/journals/pla...
#OpenAccess
Our paper on the first UV-sensitive rhodopsin channel, the Apusomonad rhodopsin, has been published in PNAS! 🎉
This is a new family distinct from canonical ChRs with a novel transport mechanism🦠—paving the way for future multi-wavelength optogenetics! 🔬
www.pnas.org/doi/full/10....
#OpenAccess
This is a new family distinct from canonical ChRs with a novel transport mechanism🦠—paving the way for future multi-wavelength optogenetics! 🔬
www.pnas.org/doi/full/10....
#OpenAccess
October 13, 2025 at 8:31 PM
Our paper on the first UV-sensitive rhodopsin channel, the Apusomonad rhodopsin, has been published in PNAS! 🎉
This is a new family distinct from canonical ChRs with a novel transport mechanism🦠—paving the way for future multi-wavelength optogenetics! 🔬
www.pnas.org/doi/full/10....
#OpenAccess
This is a new family distinct from canonical ChRs with a novel transport mechanism🦠—paving the way for future multi-wavelength optogenetics! 🔬
www.pnas.org/doi/full/10....
#OpenAccess
A new heliorhodopsin (V2HeR) from a giant virus by the Prof. Kandori lab🧬 Congratulations!🎉
www.jstage.jst.go.jp/article/biop...
@bejalab.bsky.social
www.jstage.jst.go.jp/article/biop...
@bejalab.bsky.social
October 4, 2025 at 5:34 AM
A new heliorhodopsin (V2HeR) from a giant virus by the Prof. Kandori lab🧬 Congratulations!🎉
www.jstage.jst.go.jp/article/biop...
@bejalab.bsky.social
www.jstage.jst.go.jp/article/biop...
@bejalab.bsky.social
A preprint on a newly discovered long-wavelength-absorbing rhodopsin channel has been released. This molecule was identified based on machine-learning predictions that we have been developing with Prof. Ichiro Takeuchi’s group at Nagoya University🧬
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
September 17, 2025 at 8:15 AM
A preprint on a newly discovered long-wavelength-absorbing rhodopsin channel has been released. This molecule was identified based on machine-learning predictions that we have been developing with Prof. Ichiro Takeuchi’s group at Nagoya University🧬
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Time-resolved FTIR study of anion channelrhodopsin, GtACR1. The O intermediate can contribute to channel opening upon photoexcitation🔦🌟
www.nature.com/articles/s42...
www.nature.com/articles/s42...
August 11, 2025 at 1:11 AM
Time-resolved FTIR study of anion channelrhodopsin, GtACR1. The O intermediate can contribute to channel opening upon photoexcitation🔦🌟
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Two papers from our lab were featured as cover art—Takashi’s bestrhodopsin mimicking GR for the Supplementary Cover of JPC Lett., and Takahashi-kun’s HulaChrimson for the Cover Picture of BPPB! ✨🥳
pubs.acs.org/toc/jpclcd/1...
www.biophys.jp/biophysics_a...
pubs.acs.org/toc/jpclcd/1...
www.biophys.jp/biophysics_a...
July 30, 2025 at 2:46 AM
Two papers from our lab were featured as cover art—Takashi’s bestrhodopsin mimicking GR for the Supplementary Cover of JPC Lett., and Takahashi-kun’s HulaChrimson for the Cover Picture of BPPB! ✨🥳
pubs.acs.org/toc/jpclcd/1...
www.biophys.jp/biophysics_a...
pubs.acs.org/toc/jpclcd/1...
www.biophys.jp/biophysics_a...
A new paper led by Hiroto (M2 student) on the novel channelrhodopsin HulaChrimson is now out in BPPB!✨ Interestingly, despite high similarity to red-absorbing Chrimson and sharing key residues, HulaChrimson shows blue absorption🫐🧐 www.jstage.jst.go.jp/article/biop...
#OpenAccess
#OpenAccess
July 4, 2025 at 9:00 PM
A new paper led by Hiroto (M2 student) on the novel channelrhodopsin HulaChrimson is now out in BPPB!✨ Interestingly, despite high similarity to red-absorbing Chrimson and sharing key residues, HulaChrimson shows blue absorption🫐🧐 www.jstage.jst.go.jp/article/biop...
#OpenAccess
#OpenAccess
Our new study by Takashi, Yuma, and Masae on color-tuning mechanism of bestrhodopsin was published in JPC Lett.!🙌✨By introducing its residues into GR, we revealed the role of the counterion triad and key residues for red-shifted absorption and unique isomerization😊
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
June 20, 2025 at 11:45 PM
Our new study by Takashi, Yuma, and Masae on color-tuning mechanism of bestrhodopsin was published in JPC Lett.!🙌✨By introducing its residues into GR, we revealed the role of the counterion triad and key residues for red-shifted absorption and unique isomerization😊
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Time-resolved Raman study on GtACR1 has been published in JPC Lett.!🥳 Led by Dr. Shibata and in collaboration with Prof. Akiyama's and Prof. Kato(@emekato.bsky.social)'s teams, we explored structural and H-bond changes of retinal after its photoisomerization.📊✨
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
June 12, 2025 at 8:44 PM
Time-resolved Raman study on GtACR1 has been published in JPC Lett.!🥳 Led by Dr. Shibata and in collaboration with Prof. Akiyama's and Prof. Kato(@emekato.bsky.social)'s teams, we explored structural and H-bond changes of retinal after its photoisomerization.📊✨
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
５月は柏キャンパスが一番気持ち良くなる季節です☀️🌲🌳😊
May is the most pleasant season on the Kashiwa Campus. ☀️🌲🌳😊
May is the most pleasant season on the Kashiwa Campus. ☀️🌲🌳😊
May 1, 2025 at 12:18 AM
５月は柏キャンパスが一番気持ち良くなる季節です☀️🌲🌳😊
May is the most pleasant season on the Kashiwa Campus. ☀️🌲🌳😊
May is the most pleasant season on the Kashiwa Campus. ☀️🌲🌳😊
Review article on four decades of computational studies on the proton transfer process in bacteriorhodopsin, by Prof. Bondar and Prof. Smith, in Biophys. J.
www.sciencedirect.com/science/arti...
@biophysj.bsky.social
www.sciencedirect.com/science/arti...
@biophysj.bsky.social
April 6, 2025 at 10:53 PM
Review article on four decades of computational studies on the proton transfer process in bacteriorhodopsin, by Prof. Bondar and Prof. Smith, in Biophys. J.
www.sciencedirect.com/science/arti...
@biophysj.bsky.social
www.sciencedirect.com/science/arti...
@biophysj.bsky.social
Our PhD student Lyu-kun & Dr Takaramoto’s paper has been published in J. Phys. Chem. B special issue “Massimo Olivucci Festschrift”!✨ We have found that H+-pumping rhodopsin from plant-associated bacteria, Pseudomonas putida, is activated by weak organic acids!🌱🦠🙌 pubs.acs.org/doi/10.1021/...
March 19, 2025 at 1:39 PM
Our PhD student Lyu-kun & Dr Takaramoto’s paper has been published in J. Phys. Chem. B special issue “Massimo Olivucci Festschrift”!✨ We have found that H+-pumping rhodopsin from plant-associated bacteria, Pseudomonas putida, is activated by weak organic acids!🌱🦠🙌 pubs.acs.org/doi/10.1021/...
明後日3月11日（火）16時から、名古屋工業大学・神取秀樹先生の上原賞の受賞講演🎖️がオンラインライブ配信されます💻✨まだ登録可能ですので、お時間のある方はぜひお申し込みください！
www.ueharazaidan.or.jp/ueharasho-ko...
www.ueharazaidan.or.jp/ueharasho-ko...
March 8, 2025 at 9:15 PM
明後日3月11日（火）16時から、名古屋工業大学・神取秀樹先生の上原賞の受賞講演🎖️がオンラインライブ配信されます💻✨まだ登録可能ですので、お時間のある方はぜひお申し込みください！
www.ueharazaidan.or.jp/ueharasho-ko...
www.ueharazaidan.or.jp/ueharasho-ko...
雪、降ってきた〜❄️
It's snowing❄️
It's snowing❄️
March 3, 2025 at 4:50 AM
雪、降ってきた〜❄️
It's snowing❄️
It's snowing❄️
New distinctive blue-shifted anion channelrhodopsins, ancyromonad ACRs, by Prof. Spudich and his team! 👀 Great work!
www.biorxiv.org/content/10.1...
@biorxivpreprint.bsky.social @leonidbiophys.bsky.social
www.biorxiv.org/content/10.1...
@biorxivpreprint.bsky.social @leonidbiophys.bsky.social
March 2, 2025 at 12:31 AM
New distinctive blue-shifted anion channelrhodopsins, ancyromonad ACRs, by Prof. Spudich and his team! 👀 Great work!
www.biorxiv.org/content/10.1...
@biorxivpreprint.bsky.social @leonidbiophys.bsky.social
www.biorxiv.org/content/10.1...
@biorxivpreprint.bsky.social @leonidbiophys.bsky.social
BPS2025に参加のため、LAに着きました✈️🇺🇸明日はOptogeneticsのSession chairと自分のInvite talkをする予定です。
Inoue is attending the BPS2025 in LA✈️🇺🇸He will chair and give a talk at Optogenetics session tomorrow.
Inoue is attending the BPS2025 in LA✈️🇺🇸He will chair and give a talk at Optogenetics session tomorrow.
February 16, 2025 at 10:04 PM
BPS2025に参加のため、LAに着きました✈️🇺🇸明日はOptogeneticsのSession chairと自分のInvite talkをする予定です。
Inoue is attending the BPS2025 in LA✈️🇺🇸He will chair and give a talk at Optogenetics session tomorrow.
Inoue is attending the BPS2025 in LA✈️🇺🇸He will chair and give a talk at Optogenetics session tomorrow.
井上研に、新たに30 cmサイズの物性犬がやってきました✨研究室にご訪問いただく皆様を、笑顔でお出迎えします🐶
February 13, 2025 at 1:28 AM
井上研に、新たに30 cmサイズの物性犬がやってきました✨研究室にご訪問いただく皆様を、笑顔でお出迎えします🐶
今年の日本生物物理学会関東支部会・研究会のサイトがオープンしました！✨今年は東京大学・物性研究所にて、3月4日(火)～5日(水)にかけて開催されます（井上が世話人です）。学生の方は参加費無料で事前参加登録いただけますので、ご興味のある方はぜひご参加ください！😊
www.biophys-kanto.org/meeting.html
www.biophys-kanto.org/meeting.html
January 17, 2025 at 10:09 AM
今年の日本生物物理学会関東支部会・研究会のサイトがオープンしました！✨今年は東京大学・物性研究所にて、3月4日(火)～5日(水)にかけて開催されます（井上が世話人です）。学生の方は参加費無料で事前参加登録いただけますので、ご興味のある方はぜひご参加ください！😊
www.biophys-kanto.org/meeting.html
www.biophys-kanto.org/meeting.html
ICRPの後はブカレスト大学のAna-Nicoleta Bondar先生を訪問し、昨日無事に日本に戻ってきました。あちらではブカレスト大学の年次会議で基調講演もさせていただきました👨💼今回は、かなり長い出張でしたが、たくさんの素晴らしい出会いがあり、とても充実したヨーロッパ遠征でした✈️
November 27, 2024 at 9:24 PM
ICRPの後はブカレスト大学のAna-Nicoleta Bondar先生を訪問し、昨日無事に日本に戻ってきました。あちらではブカレスト大学の年次会議で基調講演もさせていただきました👨💼今回は、かなり長い出張でしたが、たくさんの素晴らしい出会いがあり、とても充実したヨーロッパ遠征でした✈️
A new paper on a spectroscopic and theoretical study of the quantum-mechanical dynamics of voltage-sensitive fluorescent AR3 variants was published in Chem. Sci.!!🥳🎉 The energy barrier of retinal bond twisting is essential.
pubs.rsc.org/en/content/a...
pubs.rsc.org/en/content/a...
November 21, 2024 at 5:13 AM
A new paper on a spectroscopic and theoretical study of the quantum-mechanical dynamics of voltage-sensitive fluorescent AR3 variants was published in Chem. Sci.!!🥳🎉 The energy barrier of retinal bond twisting is essential.
pubs.rsc.org/en/content/a...
pubs.rsc.org/en/content/a...
電位依存的蛍光センサーであるAR3変異体の反応ダイナミクスに関する論文がChem. Sci.に公開されました！🥳🎉レチナールの異性化障壁が鍵であることが、超高速分光計測と理論計算によって明らかにされました。
pubs.rsc.org/en/content/a...
pubs.rsc.org/en/content/a...
November 21, 2024 at 5:11 AM
電位依存的蛍光センサーであるAR3変異体の反応ダイナミクスに関する論文がChem. Sci.に公開されました！🥳🎉レチナールの異性化障壁が鍵であることが、超高速分光計測と理論計算によって明らかにされました。
pubs.rsc.org/en/content/a...
pubs.rsc.org/en/content/a...