Congratulations, Frank!

Again, where exactly he used the term is a mystery for me now. While it can be attributed to my imagination, that is unlikely. I find it useful while discussing aspects of gene regulation.

However, Brenner highlighted that a major unsolved problem (“the left-hand side”) was how genes, through complex regulatory processes, give rise to the intricate architectures, behaviours, and functions in multicellular organisms.

This problem—how genetic information determines protein sequence—was solved mainly with the understanding of the genetic code and protein synthesis.

In his Nobel Lecture, Brenner explained that early molecular biology (“the right-hand side”) focused on how the linear sequence of DNA specifies the linear sequence of amino acids in proteins.

I read this—the“left-hand-side problem”—in a piece by Sydney Brenner. I can’t trace the piece or video now. I recollect that Brenner refers to the unresolved challenge of understanding how the cellular environment regulates genes to participate in creating the complex structures and functions.