Ksenia Skvortsova
@kseskv.bsky.social
Developmental and Disease Epigenomics Laboratory Head at the Garvan Institute, Australia.
Reposted by Ksenia Skvortsova
1/ I’m very excited to share my postdoc work with @kseskv.bsky.social, in collaboration with @oligriffith.bsky.social. We explore embryonic DNA methylation reprogramming in the fat-tailed dunnart, an Australian marsupial 🦘🌏 www.biorxiv.org/content/10.1...
www.biorxiv.org
November 12, 2025 at 2:57 AM
1/ I’m very excited to share my postdoc work with @kseskv.bsky.social, in collaboration with @oligriffith.bsky.social. We explore embryonic DNA methylation reprogramming in the fat-tailed dunnart, an Australian marsupial 🦘🌏 www.biorxiv.org/content/10.1...
Reposted by Ksenia Skvortsova
The Abstract submission and Earlybird registration deadlines have been extended! You now have until 𝐅𝐫𝐢𝐝𝐚𝐲 𝟐𝟏 𝐍𝐨𝐯𝐞𝐦𝐛𝐞𝐫 to submit and save! Do not forget to apply for awards if eligible! https://www.lornegenome.org/registrations
Looking forward to seeing you at Lorne!
Looking forward to seeing you at Lorne!
Registrations — Lorne Genome
Registrations are now open! Secure your ticket to attend Lorne Genome 2022!
www.lornegenome.org
November 10, 2025 at 1:28 AM
The Abstract submission and Earlybird registration deadlines have been extended! You now have until 𝐅𝐫𝐢𝐝𝐚𝐲 𝟐𝟏 𝐍𝐨𝐯𝐞𝐦𝐛𝐞𝐫 to submit and save! Do not forget to apply for awards if eligible! https://www.lornegenome.org/registrations
Looking forward to seeing you at Lorne!
Looking forward to seeing you at Lorne!
Reposted by Ksenia Skvortsova
💥 Another fruitful collaboration!
Along with @obog.bsky.social & Juan Tena’s teams we provide a multiomics study of zebrafish spermatogenesis
🐟#meiosis
👇
www.embopress.org/doi/full/10....
Along with @obog.bsky.social & Juan Tena’s teams we provide a multiomics study of zebrafish spermatogenesis
🐟#meiosis
👇
www.embopress.org/doi/full/10....
October 16, 2025 at 6:10 PM
💥 Another fruitful collaboration!
Along with @obog.bsky.social & Juan Tena’s teams we provide a multiomics study of zebrafish spermatogenesis
🐟#meiosis
👇
www.embopress.org/doi/full/10....
Along with @obog.bsky.social & Juan Tena’s teams we provide a multiomics study of zebrafish spermatogenesis
🐟#meiosis
👇
www.embopress.org/doi/full/10....
Reposted by Ksenia Skvortsova
Did transposable elements shape brain evolution — and if so, which ones, and in which cell states and lineages? Led by @tyamadat.bsky.social, we explored this question in cerebellum development using sequence-based deep learning models!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 16, 2025 at 10:01 PM
Did transposable elements shape brain evolution — and if so, which ones, and in which cell states and lineages? Led by @tyamadat.bsky.social, we explored this question in cerebellum development using sequence-based deep learning models!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Ksenia Skvortsova
Please join us for several days of fantastic science at Lorne Genome 2026!
We're thrilled to welcome Prof Amander Clark, a renowned stem cell biologist whose work focuses on in vitro gametogenesis and ovarian reserve formation: https://www.lornegenome.org/amander-clark
We're thrilled to welcome Prof Amander Clark, a renowned stem cell biologist whose work focuses on in vitro gametogenesis and ovarian reserve formation: https://www.lornegenome.org/amander-clark
October 14, 2025 at 10:55 PM
Please join us for several days of fantastic science at Lorne Genome 2026!
We're thrilled to welcome Prof Amander Clark, a renowned stem cell biologist whose work focuses on in vitro gametogenesis and ovarian reserve formation: https://www.lornegenome.org/amander-clark
We're thrilled to welcome Prof Amander Clark, a renowned stem cell biologist whose work focuses on in vitro gametogenesis and ovarian reserve formation: https://www.lornegenome.org/amander-clark
Reposted by Ksenia Skvortsova
Secure your early bird rate for Lorne Genome 2026 before Nov 7th! lornegenome.org
We are excited to welcome Prof Duncan Odom as a speaker - a leading researcher in regulatory genomics and cancer genome evolution https://www.lornegenome.org/duncan-odum
We are excited to welcome Prof Duncan Odom as a speaker - a leading researcher in regulatory genomics and cancer genome evolution https://www.lornegenome.org/duncan-odum
October 2, 2025 at 11:20 AM
Secure your early bird rate for Lorne Genome 2026 before Nov 7th! lornegenome.org
We are excited to welcome Prof Duncan Odom as a speaker - a leading researcher in regulatory genomics and cancer genome evolution https://www.lornegenome.org/duncan-odum
We are excited to welcome Prof Duncan Odom as a speaker - a leading researcher in regulatory genomics and cancer genome evolution https://www.lornegenome.org/duncan-odum
Reposted by Ksenia Skvortsova
Don't forget to register and submit an abstract for the 𝐋𝐨𝐫𝐧𝐞 𝐆𝐞𝐧𝐨𝐦𝐞 𝟐𝟎𝟐𝟔!
𝐓𝐡𝐢𝐬 𝐰𝐞𝐞𝐤'𝐬 𝐬𝐩𝐞𝐚𝐤𝐞𝐫 𝐬𝐩𝐨𝐭𝐥𝐢𝐠𝐡𝐭: 𝐏𝐫𝐨𝐟 𝐁𝐫𝐞𝐧𝐝𝐚 𝐀𝐧𝐝𝐫𝐞𝐰𝐬, a leading systems biologist whose research focuses on mapping genetic interaction networks and protein localisation patterns in yeast and human cells.
𝐓𝐡𝐢𝐬 𝐰𝐞𝐞𝐤'𝐬 𝐬𝐩𝐞𝐚𝐤𝐞𝐫 𝐬𝐩𝐨𝐭𝐥𝐢𝐠𝐡𝐭: 𝐏𝐫𝐨𝐟 𝐁𝐫𝐞𝐧𝐝𝐚 𝐀𝐧𝐝𝐫𝐞𝐰𝐬, a leading systems biologist whose research focuses on mapping genetic interaction networks and protein localisation patterns in yeast and human cells.
Registrations — Lorne Genome
Registrations are now open! Secure your ticket to attend Lorne Genome 2022!
www.lornegenome.org
September 24, 2025 at 1:10 AM
Don't forget to register and submit an abstract for the 𝐋𝐨𝐫𝐧𝐞 𝐆𝐞𝐧𝐨𝐦𝐞 𝟐𝟎𝟐𝟔!
𝐓𝐡𝐢𝐬 𝐰𝐞𝐞𝐤'𝐬 𝐬𝐩𝐞𝐚𝐤𝐞𝐫 𝐬𝐩𝐨𝐭𝐥𝐢𝐠𝐡𝐭: 𝐏𝐫𝐨𝐟 𝐁𝐫𝐞𝐧𝐝𝐚 𝐀𝐧𝐝𝐫𝐞𝐰𝐬, a leading systems biologist whose research focuses on mapping genetic interaction networks and protein localisation patterns in yeast and human cells.
𝐓𝐡𝐢𝐬 𝐰𝐞𝐞𝐤'𝐬 𝐬𝐩𝐞𝐚𝐤𝐞𝐫 𝐬𝐩𝐨𝐭𝐥𝐢𝐠𝐡𝐭: 𝐏𝐫𝐨𝐟 𝐁𝐫𝐞𝐧𝐝𝐚 𝐀𝐧𝐝𝐫𝐞𝐰𝐬, a leading systems biologist whose research focuses on mapping genetic interaction networks and protein localisation patterns in yeast and human cells.
Reposted by Ksenia Skvortsova
Just been reading this nice review. Taught someone who has never really done developmental biology a lot! Thanks and congrats to all involved. #epigenetics
September 23, 2025 at 2:44 PM
Just been reading this nice review. Taught someone who has never really done developmental biology a lot! Thanks and congrats to all involved. #epigenetics
Reposted by Ksenia Skvortsova
How many chromosomes can an animal have?
In our paper out now in @currentbiology.bsky.social we show that the Atlas blue butterfly has 229 chromosome pairs- the highest in diploid Metazoa! These arose by rapid autosome fragmentation while sex chromosomes stayed intact.
www.cell.com/current-biol...
In our paper out now in @currentbiology.bsky.social we show that the Atlas blue butterfly has 229 chromosome pairs- the highest in diploid Metazoa! These arose by rapid autosome fragmentation while sex chromosomes stayed intact.
www.cell.com/current-biol...
Constraints on chromosome evolution revealed by the 229 chromosome pairs of the Atlas blue butterfly
The genome of the Atlas blue butterfly contains ten times more chromosomes than most
butterflies, and more than any other known diploid animal. Wright et al. show that
this extraordinary karyotype is ...
tinyurl.com
September 11, 2025 at 3:22 PM
How many chromosomes can an animal have?
In our paper out now in @currentbiology.bsky.social we show that the Atlas blue butterfly has 229 chromosome pairs- the highest in diploid Metazoa! These arose by rapid autosome fragmentation while sex chromosomes stayed intact.
www.cell.com/current-biol...
In our paper out now in @currentbiology.bsky.social we show that the Atlas blue butterfly has 229 chromosome pairs- the highest in diploid Metazoa! These arose by rapid autosome fragmentation while sex chromosomes stayed intact.
www.cell.com/current-biol...
Reposted by Ksenia Skvortsova
Earlybird registration & abstract submissions now open for the 𝟒𝟕𝐭𝐡 𝐋𝐨𝐫𝐧𝐞 𝐆𝐞𝐧𝐨𝐦𝐞 𝐂𝐨𝐧𝐟𝐞𝐫𝐞𝐧𝐜𝐞, 𝟏𝟓-𝟏𝟖𝐭𝐡 𝐅𝐞𝐛 𝟐𝟎𝟐𝟔: https://www.lornegenome.org/registrations (deadline 7th Nov 2025)
Speakers: https://www.lornegenome.org/speakers
We look forward to seeing you there!
Speakers: https://www.lornegenome.org/speakers
We look forward to seeing you there!
Speakers — Lorne Genome
No description found
www.lornegenome.org
September 3, 2025 at 10:00 PM
Earlybird registration & abstract submissions now open for the 𝟒𝟕𝐭𝐡 𝐋𝐨𝐫𝐧𝐞 𝐆𝐞𝐧𝐨𝐦𝐞 𝐂𝐨𝐧𝐟𝐞𝐫𝐞𝐧𝐜𝐞, 𝟏𝟓-𝟏𝟖𝐭𝐡 𝐅𝐞𝐛 𝟐𝟎𝟐𝟔: https://www.lornegenome.org/registrations (deadline 7th Nov 2025)
Speakers: https://www.lornegenome.org/speakers
We look forward to seeing you there!
Speakers: https://www.lornegenome.org/speakers
We look forward to seeing you there!
Reposted by Ksenia Skvortsova
ANZSCDB is pleased to launch our Zoom seminar series!
Our first seminar kicks off on Thursday August 28th, 2025 at 12pm AEST with Professor Jose Polo and Dr Melanie White.
Please register and attend to ensure the success and long-term sustainability of this initiative.
Our first seminar kicks off on Thursday August 28th, 2025 at 12pm AEST with Professor Jose Polo and Dr Melanie White.
Please register and attend to ensure the success and long-term sustainability of this initiative.
August 21, 2025 at 12:10 AM
ANZSCDB is pleased to launch our Zoom seminar series!
Our first seminar kicks off on Thursday August 28th, 2025 at 12pm AEST with Professor Jose Polo and Dr Melanie White.
Please register and attend to ensure the success and long-term sustainability of this initiative.
Our first seminar kicks off on Thursday August 28th, 2025 at 12pm AEST with Professor Jose Polo and Dr Melanie White.
Please register and attend to ensure the success and long-term sustainability of this initiative.
Reposted by Ksenia Skvortsova
This is not a HiC map! Ever wondered if multiple enhancers get activated simultaneously? We measured chromatin accessibility on thousands of molecules by nanopore to create genome-wide co-accessibility maps. Proud of @mathias-boulanger.bsky.social @kasitc.bsky.social Biology in the thread👇
August 18, 2025 at 1:00 PM
This is not a HiC map! Ever wondered if multiple enhancers get activated simultaneously? We measured chromatin accessibility on thousands of molecules by nanopore to create genome-wide co-accessibility maps. Proud of @mathias-boulanger.bsky.social @kasitc.bsky.social Biology in the thread👇
Reposted by Ksenia Skvortsova
How do enhancer-gene contacts relate to transcription activation? In mouse embryonic stem cells, a combo of STED, oligoFISH & RNA FISH shows that 3% of Dppa3 alleles transcribe. For these, enhancers and promoters come closer (panel E). Stumberger ... Leonhardt & Harz www.biorxiv.org/content/10.1...
July 26, 2025 at 9:36 PM
How do enhancer-gene contacts relate to transcription activation? In mouse embryonic stem cells, a combo of STED, oligoFISH & RNA FISH shows that 3% of Dppa3 alleles transcribe. For these, enhancers and promoters come closer (panel E). Stumberger ... Leonhardt & Harz www.biorxiv.org/content/10.1...
Reposted by Ksenia Skvortsova
Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...
The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate - Nature Cell Biology
Marin et al. report the role of lamin proteins and the lamin B receptor (LBR) in chromatin positioning at the nuclear periphery. Knockout of all lamins and LBR in mouse embryonic stem cells leads to h...
www.nature.com
July 22, 2025 at 5:10 PM
Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...
Reposted by Ksenia Skvortsova
Reposted by Ksenia Skvortsova
Our study on a male-essential microRNA and the evolution of other dosage compensation mechanisms in birds is now out in Nature! www.nature.com/articles/s41...
A male-essential miRNA is key for avian sex chromosome dosage compensation - Nature
Birds have evolved a unique sex chromosome dosage compensation mechanism involving the male-biased microRNA (miR-2954), which is essential for male survival by regulating the expression of dosage-sens...
www.nature.com
July 16, 2025 at 3:23 PM
Our study on a male-essential microRNA and the evolution of other dosage compensation mechanisms in birds is now out in Nature! www.nature.com/articles/s41...
Reposted by Ksenia Skvortsova
No new genes needed to fly - just rewire what you have! 🦇🧬
Great new paper from the labs of @fany-real.bsky.social @stemundi.bsky.social @dariloops.bsky.social
doi.org/10.1038/s415...
#EvoDevo #SingleCell #BatWings
Great new paper from the labs of @fany-real.bsky.social @stemundi.bsky.social @dariloops.bsky.social
doi.org/10.1038/s415...
#EvoDevo #SingleCell #BatWings
July 16, 2025 at 1:49 PM
No new genes needed to fly - just rewire what you have! 🦇🧬
Great new paper from the labs of @fany-real.bsky.social @stemundi.bsky.social @dariloops.bsky.social
doi.org/10.1038/s415...
#EvoDevo #SingleCell #BatWings
Great new paper from the labs of @fany-real.bsky.social @stemundi.bsky.social @dariloops.bsky.social
doi.org/10.1038/s415...
#EvoDevo #SingleCell #BatWings
Reposted by Ksenia Skvortsova
OrthoFinder just dropped a major update
It’s faster, more accurate, and ready for thousands of genomes
Let’s break it down (1/10)
github.com/OrthoFinder/...
www.biorxiv.org/content/10.1...
It’s faster, more accurate, and ready for thousands of genomes
Let’s break it down (1/10)
github.com/OrthoFinder/...
www.biorxiv.org/content/10.1...
July 16, 2025 at 5:51 PM
OrthoFinder just dropped a major update
It’s faster, more accurate, and ready for thousands of genomes
Let’s break it down (1/10)
github.com/OrthoFinder/...
www.biorxiv.org/content/10.1...
It’s faster, more accurate, and ready for thousands of genomes
Let’s break it down (1/10)
github.com/OrthoFinder/...
www.biorxiv.org/content/10.1...
Reposted by Ksenia Skvortsova
I am very excited to share our latest work where we describe a new method to profile genome-wide chromatin transitions over time in single cells. Great collaborative effort with the van Oudenaarden group @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social www.nature.com/articles/s41....
Retrospective and multifactorial single-cell profiling reveals sequential chromatin reorganization during X inactivation - Nature Cell Biology
Kefalopoulou, Rullens et al. develop Dam&ChIC to assay chromatin state at two different time points in the same cell. The method was used to study the reorganization of LADs during cell division a...
www.nature.com
July 10, 2025 at 2:36 PM
I am very excited to share our latest work where we describe a new method to profile genome-wide chromatin transitions over time in single cells. Great collaborative effort with the van Oudenaarden group @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social www.nature.com/articles/s41....
Reposted by Ksenia Skvortsova
Our work bridging enhancer-promoter proximity to phenotypic outcomes in vivo is out! Shout out to @olimpiabompadre.bsky.social, to Marie Kmita's lab, and to all the co-authors. www.nature.com/articles/s41...
Liebenberg syndrome severity arises from variations in Pitx1 locus topology and proportion of ectopically transcribing cells - Nature Communications
Here the authors show that reducing enhancer-promoter distance at the Pitx1 locus increases proportion of Pitx1 forelimb expressing cells, worsening skeletal defects in Liebenberg syndrome. They also ...
www.nature.com
July 9, 2025 at 11:58 AM
Our work bridging enhancer-promoter proximity to phenotypic outcomes in vivo is out! Shout out to @olimpiabompadre.bsky.social, to Marie Kmita's lab, and to all the co-authors. www.nature.com/articles/s41...
Reposted by Ksenia Skvortsova
Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature Genetics
Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c...
www.nature.com
July 9, 2025 at 10:05 AM
Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Reposted by Ksenia Skvortsova
Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/
Range extender mediates long-distance enhancer activity - Nature
The REX element is associated with long-range enhancer–promoter interactions.
www.nature.com
July 2, 2025 at 4:17 PM
Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/
Reposted by Ksenia Skvortsova
How do non-coding variants in enhancers lead to disease? Happy to share our recent work, led by @ewholling.bsky.social, in which we discovered that poised chromatin sensitizes enhancers to aberrant activation by non-coding mutations, contributing to disease. www.biorxiv.org/content/10.1... 1/
June 23, 2025 at 12:57 PM
How do non-coding variants in enhancers lead to disease? Happy to share our recent work, led by @ewholling.bsky.social, in which we discovered that poised chromatin sensitizes enhancers to aberrant activation by non-coding mutations, contributing to disease. www.biorxiv.org/content/10.1... 1/
Reposted by Ksenia Skvortsova
⚠️ I am really excited to share the work of Anastasios Balaskas, an excellent PhD candidate in the lab, with the wider world. Tasos made a significant advance: generating a stem cell-based embryo model that contains both posterior and anterior neural tissues of the late-stage gastrulating embryo.
June 23, 2025 at 7:51 AM
⚠️ I am really excited to share the work of Anastasios Balaskas, an excellent PhD candidate in the lab, with the wider world. Tasos made a significant advance: generating a stem cell-based embryo model that contains both posterior and anterior neural tissues of the late-stage gastrulating embryo.
Reposted by Ksenia Skvortsova
We are delighted to share our new preprint “The evolution of gene regulatory programs controlling gonadal development in primates” www.biorxiv.org/content/10.1...
June 20, 2025 at 8:13 AM
We are delighted to share our new preprint “The evolution of gene regulatory programs controlling gonadal development in primates” www.biorxiv.org/content/10.1...