Great kick off at the annual Alliance for Healthy Aging Conference hosted by the Mayo Clinic Kogod Centre on Aging Center in Jacksonville Florida with a keynote by @adamsbioaging.bsky.social

MACS120 outperformed traditional measurements (like variant allele frequency) in predicting mortality risk and showed increased correlations with the speed of change in blood markers like lymphocyte and albumin levels.

Considering these factors, we developed MACS120 - a novel metric that combines mutation fitness and acquisition timing to predict maximum clone size a mutation will reach over a lifetime.

Second, we found that clonal coexistence matters! Mutations don't grow in isolation - when multiple clones are present in the same person, they alter each other's overall contribution to the production of blood cells.

Thanks for my lovely heme bracelet @tanyawildes.bsky.social

Great workshop on Aging and Hematology #ASH2024 pitching cell intrinsic vs cell extrinsic aging factors