5️⃣Finally, MELD Graph was a huge team effort with @konradwagstyl.bsky.social, @sophieadlerwagstyl.bsky.social, @hannahspitzer.
and our MELD consortium (@drfelicedarco.bsky.social @nathantcohen.bsky.social @metricsemma.bsky.social @kirstiejane.bsky.social @lzjwilliams.bsky.social + many others!)

New questions:
1. How are these axes mechanistically linked?
2. Is it an atlas averaging effect - is there more nuance within individuals?
3. What tools & data do we need?
4. If lots of features co-correlate with pathology, which one best links to aetiology or potential therapeutic avenues?

A similar axis seems now to be showing up everywhere: from cellular morphologies and expression markers through to cortical myelination, developmental patterns ( eg @valeriejsydnor.bsky.social shorturl.at/5gShe). It seems to be a fundamental feature of how our brains are organised.

In this new paper: shorturl.at/NbNLN, Zhang et al., combined rsfMRI, bulk and single cell gene expression data and found distinctive cellular fingerprints at the poles of the sensory-association rsfMRI gradient. But....