Kitty Sherwood
@kittysherwood.bsky.social
Postdoctoral bioinformatician at the University of Edinburgh Institute of Genetics and Cancer.
Currently working on chromosomal instability and mutational landscapes in tumours.
Happiest when out in nature!
Currently working on chromosomal instability and mutational landscapes in tumours.
Happiest when out in nature!
Reposted by Kitty Sherwood
New preprint from the lab!
Profiling triple negative breast cancer samples over time, we looked at tumour genome responses to treatment. We reveal major roles for whole genome duplication (WGD) as these tumours evolve; with WGD seen in many pre-treatment samples, but also re-emerging at recurrence.
Profiling triple negative breast cancer samples over time, we looked at tumour genome responses to treatment. We reveal major roles for whole genome duplication (WGD) as these tumours evolve; with WGD seen in many pre-treatment samples, but also re-emerging at recurrence.
Frequent Whole-Genome Duplication Events Drive the Genomic Evolution of Triple-Negative Breast Cancer During Neoadjuvant Chemotherapy https://www.biorxiv.org/content/10.1101/2025.11.17.688693v1
November 19, 2025 at 2:34 PM
New preprint from the lab!
Profiling triple negative breast cancer samples over time, we looked at tumour genome responses to treatment. We reveal major roles for whole genome duplication (WGD) as these tumours evolve; with WGD seen in many pre-treatment samples, but also re-emerging at recurrence.
Profiling triple negative breast cancer samples over time, we looked at tumour genome responses to treatment. We reveal major roles for whole genome duplication (WGD) as these tumours evolve; with WGD seen in many pre-treatment samples, but also re-emerging at recurrence.
Reposted by Kitty Sherwood
PREDICT-Meso International Conference 2026
📢ABSTRACT SUBMISSION NOW OPEN
Abstract categories
CLINICAL STUDIES & PATIENT CARE
TARGETS
MODELS & THERAPIES
RISK & RESPONSE
Submit your abstracts online at www.eventsforce.net/predict_meso... by 30 Nov 2025
#Mesothelioma #MesotheliomaConference
📢ABSTRACT SUBMISSION NOW OPEN
Abstract categories
CLINICAL STUDIES & PATIENT CARE
TARGETS
MODELS & THERAPIES
RISK & RESPONSE
Submit your abstracts online at www.eventsforce.net/predict_meso... by 30 Nov 2025
#Mesothelioma #MesotheliomaConference
September 18, 2025 at 11:29 AM
PREDICT-Meso International Conference 2026
📢ABSTRACT SUBMISSION NOW OPEN
Abstract categories
CLINICAL STUDIES & PATIENT CARE
TARGETS
MODELS & THERAPIES
RISK & RESPONSE
Submit your abstracts online at www.eventsforce.net/predict_meso... by 30 Nov 2025
#Mesothelioma #MesotheliomaConference
📢ABSTRACT SUBMISSION NOW OPEN
Abstract categories
CLINICAL STUDIES & PATIENT CARE
TARGETS
MODELS & THERAPIES
RISK & RESPONSE
Submit your abstracts online at www.eventsforce.net/predict_meso... by 30 Nov 2025
#Mesothelioma #MesotheliomaConference
Reposted by Kitty Sherwood
📢OUT @natgenet.nature.com
📰DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution.
By Francisco Gimeno-Valiente, Nnennaya Kanu and colleagues.
⬇️
www.nature.com/articles/s41...
📰DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution.
By Francisco Gimeno-Valiente, Nnennaya Kanu and colleagues.
⬇️
www.nature.com/articles/s41...
DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution - Nature Genetics
Integrated multi-omic analyses using samples from the TRACERx study highlight cross-talk between DNA hypermethylation and genomic lesions in non-small cell lung cancer.
www.nature.com
September 15, 2025 at 11:53 AM
📢OUT @natgenet.nature.com
📰DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution.
By Francisco Gimeno-Valiente, Nnennaya Kanu and colleagues.
⬇️
www.nature.com/articles/s41...
📰DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution.
By Francisco Gimeno-Valiente, Nnennaya Kanu and colleagues.
⬇️
www.nature.com/articles/s41...
Reposted by Kitty Sherwood
Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...
Fluctuating DNA methylation tracks cancer evolution at clinical scale - Nature
Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.
www.nature.com
September 10, 2025 at 3:21 PM
Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...
Reposted by Kitty Sherwood
Read more about this new study led by #IGC's Alex Loftus:
www.heraldscotland.com/news/2544702...
@cmvm-edinburghuni.bsky.social
www.heraldscotland.com/news/2544702...
@cmvm-edinburghuni.bsky.social
Scottish scientists to lead new brain tumour research
Stopping cancer cells spreading and hiding in the brain is the focus of a new research project at the University of Edinburgh.
www.heraldscotland.com
September 8, 2025 at 11:24 AM
Read more about this new study led by #IGC's Alex Loftus:
www.heraldscotland.com/news/2544702...
@cmvm-edinburghuni.bsky.social
www.heraldscotland.com/news/2544702...
@cmvm-edinburghuni.bsky.social
Reposted by Kitty Sherwood
Would you like to do some unique experiments in cancer genomics and mutagenesis, in beautiful Munich? Well then apply for this PhD position: jobs.dkfz.de/en/jobs/1679...
You'll learn a lot and it'll be fun and interesting!
#DKTK @dkfz.bsky.social @lmumuenchen.bsky.social
You'll learn a lot and it'll be fun and interesting!
#DKTK @dkfz.bsky.social @lmumuenchen.bsky.social
PhD Student in Mutational Processes Driving Somatic Evolution
jobs.dkfz.de
August 19, 2025 at 2:54 PM
Would you like to do some unique experiments in cancer genomics and mutagenesis, in beautiful Munich? Well then apply for this PhD position: jobs.dkfz.de/en/jobs/1679...
You'll learn a lot and it'll be fun and interesting!
#DKTK @dkfz.bsky.social @lmumuenchen.bsky.social
You'll learn a lot and it'll be fun and interesting!
#DKTK @dkfz.bsky.social @lmumuenchen.bsky.social
Reposted by Kitty Sherwood
new out in Nature this week www.nature.com/articles/s41...
The mutagenic forces shaping the genomes of lung cancer in never smokers - Nature
An analysis of data from the Sherlock-Lung study provides insight into the mutational processes that contribute to lung cancer in never smokers, and looks at the possible role of factors such as ...
www.nature.com
July 3, 2025 at 7:07 AM
new out in Nature this week www.nature.com/articles/s41...
Great to see this out!
New publication from the lab!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Divergent trajectories to structural diversity impact patient survival in high grade serous ovarian cancer - Nature Communications
Tumour evolution and heterogeneity in high grade serous ovarian cancer (HGSOC) remains poorly characterised. Here, the authors investigate the genomic landscape of HGSOC and reveal two distinct evolut...
www.nature.com
July 1, 2025 at 2:42 PM
Great to see this out!
Reposted by Kitty Sherwood
🚨Chemo treatment upgrade!🚨
Check out our approach to modernise chemotherapy treatment published today in @natgenet.nature.com. From @cniostopcancer.bsky.social #TailorBio @cruk-ci.bsky.social www.nature.com/articles/s41... More details 👇
Check out our approach to modernise chemotherapy treatment published today in @natgenet.nature.com. From @cniostopcancer.bsky.social #TailorBio @cruk-ci.bsky.social www.nature.com/articles/s41... More details 👇
www.nature.com
June 23, 2025 at 9:03 AM
🚨Chemo treatment upgrade!🚨
Check out our approach to modernise chemotherapy treatment published today in @natgenet.nature.com. From @cniostopcancer.bsky.social #TailorBio @cruk-ci.bsky.social www.nature.com/articles/s41... More details 👇
Check out our approach to modernise chemotherapy treatment published today in @natgenet.nature.com. From @cniostopcancer.bsky.social #TailorBio @cruk-ci.bsky.social www.nature.com/articles/s41... More details 👇
Reposted by Kitty Sherwood
Our featured article: Diversity and consequences of structural variation in the human genome go.nature.com/4awEtaY #Review by Ryan L. Collins & Michael E. Talkowski @broadinstitute.org @harvard.edu @harvardmed.bsky.social
Diversity and consequences of structural variation in the human genome - Nature Reviews Genetics
Collins and Talkowski provide a broad overview of structural variation in the human genome that covers their mutational properties, the dynamics of population genetics and functional consequences in d...
go.nature.com
June 19, 2025 at 1:06 PM
Our featured article: Diversity and consequences of structural variation in the human genome go.nature.com/4awEtaY #Review by Ryan L. Collins & Michael E. Talkowski @broadinstitute.org @harvard.edu @harvardmed.bsky.social
Reposted by Kitty Sherwood
People with ME/CFS have significant differences in their blood compared with healthy individuals a new study reveals: edin.ac/43RxKXx. Listen to @cgatist.bsky.social on BBC Radio 4's Today (from 1:22:45): lnkd.in/dRGhKttp
@cmvm-edinburghuni.bsky.social @avakhamseh.bsky.social
@cmvm-edinburghuni.bsky.social @avakhamseh.bsky.social
Scale of how ME/CFS affects blood revealed
People with ME/CFS have significant differences in their blood compared with healthy individuals a new study reveals, suggesting a path towards more reliable diagnosis of the long-term debilitating il...
edin.ac
June 20, 2025 at 11:05 AM
People with ME/CFS have significant differences in their blood compared with healthy individuals a new study reveals: edin.ac/43RxKXx. Listen to @cgatist.bsky.social on BBC Radio 4's Today (from 1:22:45): lnkd.in/dRGhKttp
@cmvm-edinburghuni.bsky.social @avakhamseh.bsky.social
@cmvm-edinburghuni.bsky.social @avakhamseh.bsky.social