Would love to know more about this research project!

@cermes3.bsky.social @oxonandrew.bsky.social @gcagatgcaatg.bsky.social @charlottebrives.bsky.social @gvagrad.bsky.social

While current intervention models will undoubtely yield novel compounds, diversifying R&D systems, investing in underlying infrastructure, and building capacity beyond high-income countries is key to ensuring a more sustainable alignment of innovation & access (9/9).

Ultimately, there is a limit to what societies can afford to pay for the perpetual renewal of the antibiotic infrastructures that underpin modern and food production systems – meanwhile, alternative innovation models exist... (8/9)

Drawing on sociological research on assetization & assessing rising estimates for required push/pull incentives, we argue that trying to keep up with open-ended revenue expectations is not a sustainable public health strategy. (7/9)

Focusing on companies themselves - and particularly the SMEs who start to dominate the innovation ecosystem from ca. 2000 onwards -, the article, however, also shows that public incentives have struggled to keep up with surging profit expectations by investors and financial markets (6/9)

This narrative originated in & fell on fertile ground within high-income countries where governments began to advocate in part competing financial models from ca. 2010. The article covers proposed push & pull incentives including the creation of new PPPs, PDPs, and subscription models (5/9)

Key to the Empty Pipeline metaphor's success was its ability to present antibiotic innovation (& with it #AMR) as a market problem that could be fixed via fiscal & regulatory interventions. (4/9)

This was despite the fact that antibiotics were still generating profits, major companies were actively defending patents & most clinicians considered stewardship & access rather than innovation a priority. (3/9)

We use archival research, discourse evaluation, and financial evaluation to show how a new technological deficit imaginary - The Empty Pipeline – gradually captured political, scientific, and economic imaginaries in high-income countries from the mid-1990s onwards. (2/9)

@lshtmamrcentre.bsky.social @koutterson.bsky.social @gcagatgcaatg.bsky.social @oxonandrew.bsky.social @nataliegreenpeer.bsky.social @cermes3.bsky.social