Kimberly Kline 🏔
@kimingeneva.bsky.social
Professor, University of Geneva. We study Enterococcal biofilms, pathogenesis, and AMR. Formerly @KimInSingapore 🌴.
https://kimberlyklinelab.com/
https://kimberlyklinelab.com/
The consequence: A rapid, phenotype-first membrane “hardening” unintentionally primes the cell for the mutations that lock in high-level resistance.
Sometimes evolution doesn’t wait. E. faeecalis rehearses the phenotypic resistance program before writing it into the genome. 😎
Sometimes evolution doesn’t wait. E. faeecalis rehearses the phenotypic resistance program before writing it into the genome. 😎
November 17, 2025 at 8:27 PM
The consequence: A rapid, phenotype-first membrane “hardening” unintentionally primes the cell for the mutations that lock in high-level resistance.
Sometimes evolution doesn’t wait. E. faeecalis rehearses the phenotypic resistance program before writing it into the genome. 😎
Sometimes evolution doesn’t wait. E. faeecalis rehearses the phenotypic resistance program before writing it into the genome. 😎
The driver? LTA synthase, which boosts glycolipids when the cell senses membrane damage.
The sensor network? LiaFSR + SapRS + BsrRS, working together to flip the switch on this lipid remodeling program.
The sensor network? LiaFSR + SapRS + BsrRS, working together to flip the switch on this lipid remodeling program.
November 17, 2025 at 8:27 PM
The driver? LTA synthase, which boosts glycolipids when the cell senses membrane damage.
The sensor network? LiaFSR + SapRS + BsrRS, working together to flip the switch on this lipid remodeling program.
The sensor network? LiaFSR + SapRS + BsrRS, working together to flip the switch on this lipid remodeling program.
New work from @colomer-winter.bsky.social shows that E. faecalis doesn’t wait for mutations at all - it immediately rewires its membrane lipids as a stress response to daptomycin. And surprisingly, the cell ends up looking a lot like a resistant strain before any genetic change happens.
November 17, 2025 at 8:27 PM
New work from @colomer-winter.bsky.social shows that E. faecalis doesn’t wait for mutations at all - it immediately rewires its membrane lipids as a stress response to daptomycin. And surprisingly, the cell ends up looking a lot like a resistant strain before any genetic change happens.
Congratulations! 🤩
September 9, 2025 at 10:12 AM
Congratulations! 🤩
Yay yay! Congratulations!!
August 30, 2025 at 4:17 AM
Yay yay! Congratulations!!
Congratulations!
July 11, 2025 at 4:39 PM
Congratulations!