PS: See #BJPsych Special Issue "Psychiatric Symptoms on the Ovarian Hormone Rollercoaster" for many more super interesting papers 🎢

Implications 💥

- Results characterise #PMDD as a disorder with a dysregulated stress system

- Need for critical reflection on #CAR guidelines when studying the menstrual cycle and related disorders

- Findings might inform individualised treatment for patients

Main findings 🔎

- Patients with #PMDD show attenuated cortisol peaks compared with controls in the periovulatory phase

- Lower cortisol peaks were associated with more depressive symptoms and higher midbrain serotonin transporter binding in the premenstrual phase