Keating Lab
@keatinglab.bsky.social
MIT biology lab using computational and experimental methods to study protein structure, function, and interactions
Birnbaum and Keating present PottsMPNN, a sequence design model that learns a sequence-energy landscape from multiple sequence alignments. PottsMPNN outperforms other sequence design models and is a drop-in alternative to ProteinMPNN. Here’s the code: github.com/KeatingLab/P....
GitHub - KeatingLab/PottsMPNN: Code for running PottsMPNN to generate sequences and predict energies
Code for running PottsMPNN to generate sequences and predict energies - KeatingLab/PottsMPNN
github.com
January 18, 2026 at 6:23 AM
Birnbaum and Keating present PottsMPNN, a sequence design model that learns a sequence-energy landscape from multiple sequence alignments. PottsMPNN outperforms other sequence design models and is a drop-in alternative to ProteinMPNN. Here’s the code: github.com/KeatingLab/P....