Sarah Keane
@keanelab.bsky.social
Associate Professor of Biophysics and Chemistry @Umich. Structural Biology. NMR. Biochemistry.
all raw and processed data are also freely available doi.org/10.7302/5det...
A practical guide to RNA NMR spectral analysis for undergraduate students - NMR datasets
Nuclear magnetic resonance (NMR) spectroscopy is a powerful analytical tool that can be used to determine the structures of both small organic molecules and large biomacromolecules. Many undergradu...
doi.org
November 20, 2025 at 3:01 PM
all raw and processed data are also freely available doi.org/10.7302/5det...
Wonderful news!! Congratulations!!
September 26, 2025 at 1:50 PM
Wonderful news!! Congratulations!!
August 14, 2025 at 5:45 PM
Grace then applied this virtual screening pipeline to pre-miR-31. Here, she screened an NCI database and experimentally validated in silico hits. She then conducted a structure similarity search on the validated hits and found a more potent binder!
Integrated in silico and experimental screening identifies novel ligands that target precursor microRNA-31 at the dicer cleavage site
MicroRNAs (miRNAs) regulate gene expression and the dysregulation in mature miRNA levels has been implicated in a wide variety of diseases. In particular, altered levels of mature microRNA-31 (miR-31)...
doi.org
August 14, 2025 at 3:26 PM
Grace then applied this virtual screening pipeline to pre-miR-31. Here, she screened an NCI database and experimentally validated in silico hits. She then conducted a structure similarity search on the validated hits and found a more potent binder!
Grace developed a virtual screening approach focused on cavities identified in the (NPSL2) RNA structure. She then validated screening "hits" experimentally.
Importantly, this approach is broadly applicable to any RNA with a known 3D structure.
Importantly, this approach is broadly applicable to any RNA with a known 3D structure.
Structure guided discovery of small molecule ligands targeting the oncomiR-1 NPSL2 hairpin - Scientific Reports
Scientific Reports - Structure guided discovery of small molecule ligands targeting the oncomiR-1 NPSL2 hairpin
www.nature.com
August 14, 2025 at 3:26 PM
Grace developed a virtual screening approach focused on cavities identified in the (NPSL2) RNA structure. She then validated screening "hits" experimentally.
Importantly, this approach is broadly applicable to any RNA with a known 3D structure.
Importantly, this approach is broadly applicable to any RNA with a known 3D structure.
Great news!! Congratulations!!!
June 11, 2025 at 10:21 AM
Great news!! Congratulations!!!