Kate O'Donnell
@kateodonnell-lab.bsky.social
Scientist in the Department of Molecular Biology at UT Southwestern Medical Center. We investigate mechanisms of tumorigenesis.
https://labs.utsouthwestern.edu/odonnell-lab
https://labs.utsouthwestern.edu/odonnell-lab
Pinned
I am pleased to present a new paper from my lab led by Hari Shankar Sunil showing that the transmembrane serine protease TMPRSS11B promotes an acidified tumor microenvironment and immune suppression in squamous lung cancer, OUT NOW in EMBO Reports👇:
embopress.org/doi/full/10....
embopress.org/doi/full/10....
Reposted by Kate O'Donnell
Our lab is hiring!
This is for a postdoctoral position @ucl.ac.uk in Respiratory Medicine.
Please check out the link for more details:
www.ucl.ac.uk/work-at-ucl/...
This is for a postdoctoral position @ucl.ac.uk in Respiratory Medicine.
Please check out the link for more details:
www.ucl.ac.uk/work-at-ucl/...
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
www.ucl.ac.uk
September 25, 2025 at 3:26 PM
Our lab is hiring!
This is for a postdoctoral position @ucl.ac.uk in Respiratory Medicine.
Please check out the link for more details:
www.ucl.ac.uk/work-at-ucl/...
This is for a postdoctoral position @ucl.ac.uk in Respiratory Medicine.
Please check out the link for more details:
www.ucl.ac.uk/work-at-ucl/...
Congratulations Josh and Fred!!
Colliding ribosomes are potent signals of cellular stress. But do cells use ‘programmed’ ribosome collisions to regulate gene expression? I’m excited to present a new story from my lab led by Frederick Rehfeld(@fred-rehfeld.bsky.social) which revealed that the answer is YES! Read on to find out how👇
Oxidative stress sensing by the translation elongation machinery promotes production of detoxifying selenoproteins
Selenocysteine, incorporated into polypeptides at recoded termination codons, plays an essential role in redox biology. Using GPX1 and GPX4, selenoenzymes that mitigate oxidative stress, as reporters,...
www.biorxiv.org
November 13, 2025 at 8:14 PM
Congratulations Josh and Fred!!
Congratulations Josh, Collette, and all coauthors!🎉
Regulated decay of microRNAs plays a critical role in controlling body size in mammals! Check out our new paper in @genesdev.bsky.social and see thread previously posted with our pre-print 👇 for more info. Congrats to Collette LaVigne, Jaeil Han, and all authors!
genesdev.cshlp.org/cgi/content/...
genesdev.cshlp.org/cgi/content/...
November 12, 2025 at 9:50 PM
Congratulations Josh, Collette, and all coauthors!🎉
Reposted by Kate O'Donnell
Congrats to Kate and Hari for a very nice story and wonderful collaboration!
TMPRSS11B is a target of KLF4 and part of a chemo-refractory hillock-like state we see in squamous lung cancer. This gene contributes to acidified TME.
More coming on the hillock state after addressing FIVE reviewers!
👇🏼
TMPRSS11B is a target of KLF4 and part of a chemo-refractory hillock-like state we see in squamous lung cancer. This gene contributes to acidified TME.
More coming on the hillock state after addressing FIVE reviewers!
👇🏼
I am pleased to present a new paper from my lab led by Hari Shankar Sunil showing that the transmembrane serine protease TMPRSS11B promotes an acidified tumor microenvironment and immune suppression in squamous lung cancer, OUT NOW in EMBO Reports👇:
embopress.org/doi/full/10....
embopress.org/doi/full/10....
November 12, 2025 at 3:01 PM
Congrats to Kate and Hari for a very nice story and wonderful collaboration!
TMPRSS11B is a target of KLF4 and part of a chemo-refractory hillock-like state we see in squamous lung cancer. This gene contributes to acidified TME.
More coming on the hillock state after addressing FIVE reviewers!
👇🏼
TMPRSS11B is a target of KLF4 and part of a chemo-refractory hillock-like state we see in squamous lung cancer. This gene contributes to acidified TME.
More coming on the hillock state after addressing FIVE reviewers!
👇🏼
I am pleased to present a new paper from my lab led by Hari Shankar Sunil showing that the transmembrane serine protease TMPRSS11B promotes an acidified tumor microenvironment and immune suppression in squamous lung cancer, OUT NOW in EMBO Reports👇:
embopress.org/doi/full/10....
embopress.org/doi/full/10....
November 11, 2025 at 6:21 PM
I am pleased to present a new paper from my lab led by Hari Shankar Sunil showing that the transmembrane serine protease TMPRSS11B promotes an acidified tumor microenvironment and immune suppression in squamous lung cancer, OUT NOW in EMBO Reports👇:
embopress.org/doi/full/10....
embopress.org/doi/full/10....
Congratulations to all the awardees - but especially my husband Joshua Mendell on this well-deserved recognition. VERY proud!!! 🎉
Congratulations and welcome to the 100 new members elected today to the National Academy of Medicine! #NAMmtg nam.edu/news-and-ins...
nam.edu
November 7, 2025 at 4:17 PM
Congratulations to all the awardees - but especially my husband Joshua Mendell on this well-deserved recognition. VERY proud!!! 🎉
Reposted by Kate O'Donnell
Super pleased to announce our latest suggesting the cell of origin for #SCLC is most likely the basal cell @nature.com, not the accepted neuroendocrine cell. Implications for the earliest events in cancer, & providing new models of tuft-like cancer.
rdcu.be/eGUtj
rdcu.be/eGUtj
Basal cell of origin resolves neuroendocrine–tuft lineage plasticity in cancer
Nature - Basal cells, rather than neuroendocrine cells, have been identified as the probable origin of small cell lung cancer and other neuroendocrine–tuft cancers, explaining...
rdcu.be
September 17, 2025 at 3:21 PM
Super pleased to announce our latest suggesting the cell of origin for #SCLC is most likely the basal cell @nature.com, not the accepted neuroendocrine cell. Implications for the earliest events in cancer, & providing new models of tuft-like cancer.
rdcu.be/eGUtj
rdcu.be/eGUtj
Thank you @aacrjournals.bsky.social for selecting our story for the cover of Cancer Research!
July 17, 2025 at 9:05 PM
Thank you @aacrjournals.bsky.social for selecting our story for the cover of Cancer Research!
This is my first post here. The past few months have been challenging for science, but I enjoy learning about others' work here and wanted to share our latest study. Congrats to postdoc Shayna Thomas-Jardin on her outstanding work published in Cancer Research @theaacr.bsky.social
July 17, 2025 at 8:57 PM
This is my first post here. The past few months have been challenging for science, but I enjoy learning about others' work here and wanted to share our latest study. Congrats to postdoc Shayna Thomas-Jardin on her outstanding work published in Cancer Research @theaacr.bsky.social