Thanks Jesse!!!

▶️ Pour en savoir plus
⏩ Lire l'actu : curie.fr/actualite/di...
⏩ Lire la publication : www.nature.com/articles/s41...

Would love to be a part of the group if still space! Thanks!

Thanks so much for the kind words Adrien! 🤩 would love to discuss the next steps to integrate more mechanical measurements as planned soon!

Thanks so much Martin, hope all is well - would love your feedback!

Very proud of this work performed by the super talented Fabien Bertillot with essential support from @sol-herve.bsky.social and our amazing collaborators, especially Toni Seppälä and @sarawickstrom.bsky.social. Grateful for support from @mpi-muenster.bsky.social, NIH, and @helsinki.fi

Collectively, our work supports a model where disruption of tissue architecture & stromal cues initiate a co-evolutionary feed forward loop that drives disease aggression & suggests that quantitative analysis of tumor heterogeneity with architecture as proxy may be the key to diagnostic precision

Interestingly, while epithelial-to-mesenchymal transition states were also enriched in fragmented architectures, mechanical confinement was not sufficient to trigger #EMT. Combination of compression & soluble signals from the stroma drove further separation of regenerative stem cell and EMT states.

To figure out causation we turned to patient derived #organoids. Together with our #bioengineering colleagues in the Lutolf lab we generated topographies that mimic poor prognosis architectures. Indeed, regenerative stem cell states emerged in response to mechanical constraints and compression