Yes, but every hospital will have a scanner and a radiology department … you just need to spend time to train the staff. Just like you need to train the physiotherapists and the trial nurses.

Agree! But by whom?

But if you could then do your trial with a lot less patients…? My take on it is that ‘we’ as academics have not made/do not have the resources to make an application for the regulatory agencies to validate it. Even though #imagingnmd is doing very important work on this with the FDA.

This is not entirely true, the technique is implemented on MRI scanners of all major vendors. And the liver community also uses the same metric with FDA clearance. So yes you need a specialized center with experience, but there are more of those around than just one.

I’m not sure I agree that it should predict better, more sensitive would also help. It has already been shown that in a hypothetical trial that would slow down disease progression by 50%, the sample size for MRI would be much lower compared to functional tests. In rare diseases, this is important

Very nice collaboration with @mrifranz.bsky.social - all credits to you and your team!

Indeed :-)

Very nice summary again! However, FDG is used in PET scans, which is a different technique than MRI. In PET, radioactive tracers are used to visualize processes - in this case glucose. MRI does not use irradiation and is therefore more non-invasive. So the authors used PET and not MRI.

Congrats! Important milestone.

Not that Google was ever good, but this cartoon is a good summary of now.

Not only chocolate, but also the season’s highlight: pepernoten! Or actually kruidnoten to be precise … enjoy!

Hi Monica, could you add me? Thanks! www.lumc.nl/en/afdelinge...