Functional link here: www.biorxiv.org/cgi/content/...

All with numerous publications: @jimmunol.bsky.social, @jem.org, @cp-immunity.bsky.social, @cp-cellreports.bsky.social, @sciimmunology.bsky.social, @natimmunol.nature.com, @nature.com, @natcomms.nature.com, @cellpress.bsky.social, @pnas.org, @science.org, @eurjimmunol.bsky.social & @jci.org (4/4)

Any thoughts on where to submit the overview? Papers in the database are in over 100 different journals, with the ones next in the thread being the most frequently found (3/4)

The database includes work studying hundreds of unique antigens from hundreds of labs. Many thanks to my lab, Scott Chappell from @uvaimmunology.bsky.social , and @koenigjfe.bsky.social for helping build the database. www.immunology.virginia.edu/Taylor/Bcell... (2/4)

Make that 19 out of 19 cases. Whoops!

All 37 authors from our labs & @mc3-institute.bsky.social were critical for this work, too many to mention here! The project was ultimately led by UW M3D grad student Haroldo Rodriguez, who is co-mentored by Paul and has been visiting @uvaimmunology.bsky.social since the Taylor lab relocated (5/5)

This project was started 8 years ago when I was contacted by Paul Nghiem and David Koelle at @uwmedicine.bsky.social and Denise Galloway @fredhutch.bsky.social, who had been studying oncoprotein-specific T cell and antibody responses. And we recruited Josh Veatch's lab along the way (4/5)

Overall germinal center and Tfh cell responses did associate with outcome. And human B cells engineered to be specific for oncoprotein potently stimulate human CD4+ T cells specific engineered to express an oncoprotein-specific TCR cloned from a patient sample (3/5)

While our tumor sample cohort is small, we could accurately predict disease outcome in 14 of 14 cases by analyzing oncoprotein-specific B cells. In contrast, when we analyzed the much larger populations of B cells in the same samples, this predictive ability is diminished (2/5).