Jess
@jumpinggenomes.bsky.social
Mitos, plastids, endosymbiosis, gene transfer, origins of life, tRNAs and all things wonky in mol. evolution 🧬 Postdoc in McCutcheon lab. HHMI Hanna Gray Fellow
I love mite mt-tRNAs! I did some tRNA-seq on spider mites, and it was the first place I found this sense/antisense expression (+ some crazy short tRNAs). But I could still find all 22 tRNAs. With the mealys, it looks like this process has gone to replacement. Mirror expression -> gene loss
Hopeful monsters: unintended sequencing of famously malformed mite mitochondrial tRNAs reveals widespread expression and processing of sense–antisense pairs
Although tRNA structure is one of the most conserved and recognizable shapes in molecular biology, aberrant tRNAs are frequently found in the mitochondrial genomes of metazoans. The extremely degenerate structures of several mitochondrial tRNAs ...
pmc.ncbi.nlm.nih.gov
November 21, 2025 at 6:46 PM
I love mite mt-tRNAs! I did some tRNA-seq on spider mites, and it was the first place I found this sense/antisense expression (+ some crazy short tRNAs). But I could still find all 22 tRNAs. With the mealys, it looks like this process has gone to replacement. Mirror expression -> gene loss
I certainly like to think about it! I mention the implications for early decoding systems in the discussion because theres been a history of theorizing mirrored pairs of tRNAs and aaRSs at the origin of translation.
November 15, 2025 at 8:25 AM
I certainly like to think about it! I mention the implications for early decoding systems in the discussion because theres been a history of theorizing mirrored pairs of tRNAs and aaRSs at the origin of translation.
The grad students in the lab are passing around my copy right now. Page 182 mentions one of the obscure systems we work with 🪆
May 20, 2025 at 1:41 PM
The grad students in the lab are passing around my copy right now. Page 182 mentions one of the obscure systems we work with 🪆
Love the comparison across different organisms. Always beautiful work and keeping an eye on the big picture. Bravo 🍾
March 21, 2025 at 2:57 PM
Love the comparison across different organisms. Always beautiful work and keeping an eye on the big picture. Bravo 🍾