Christopher Ing
@jsci.bsky.social
Co-founder (https://www.proteinqure.com/), Toronto-based (🇨🇦), biophysicist (💻), peptide drug designer (💉), programmer (🐍), DJ (🎶), fan of felines (🐈). Are you looking for a job in drug discovery in Canada? DM me.
2023: "de novo antibody design is solved" -AbSci
2024: "de novo antibody design is solved, we raised $1B on this" -Xaira
2025: "de novo antibody design is solved, the last time was jokes" -Chai, Nabla
20XX: "de novo antibody design is solved, can anyone hear me... anyone out there?" -Startup X
2024: "de novo antibody design is solved, we raised $1B on this" -Xaira
2025: "de novo antibody design is solved, the last time was jokes" -Chai, Nabla
20XX: "de novo antibody design is solved, can anyone hear me... anyone out there?" -Startup X
November 19, 2025 at 8:56 PM
2023: "de novo antibody design is solved" -AbSci
2024: "de novo antibody design is solved, we raised $1B on this" -Xaira
2025: "de novo antibody design is solved, the last time was jokes" -Chai, Nabla
20XX: "de novo antibody design is solved, can anyone hear me... anyone out there?" -Startup X
2024: "de novo antibody design is solved, we raised $1B on this" -Xaira
2025: "de novo antibody design is solved, the last time was jokes" -Chai, Nabla
20XX: "de novo antibody design is solved, can anyone hear me... anyone out there?" -Startup X
Trick-or-treaters weren't the only ones wearing a mask this Halloween, doi.org/10.1093/nar/...
Improved targeted delivery of antisense oligonucleotide with an antibody mask
Abstract. Antisense oligonucleotides (ASOs) are synthetic nucleic acid strands designed to modulate gene expression by binding to RNA transcripts. In brain
doi.org
November 3, 2025 at 1:32 PM
Trick-or-treaters weren't the only ones wearing a mask this Halloween, doi.org/10.1093/nar/...
Critics: "Boo, -latest/greatest AI drug discovery method- only works if you have a similar training example!"
Biotech Industry: "Hurry, let's find the smallest possible modification to this approved ligand which hits the identical target and epitope"
Biotech Industry: "Hurry, let's find the smallest possible modification to this approved ligand which hits the identical target and epitope"
October 29, 2025 at 3:34 PM
Critics: "Boo, -latest/greatest AI drug discovery method- only works if you have a similar training example!"
Biotech Industry: "Hurry, let's find the smallest possible modification to this approved ligand which hits the identical target and epitope"
Biotech Industry: "Hurry, let's find the smallest possible modification to this approved ligand which hits the identical target and epitope"
Real data tracking my head nodding at the Autechre tour stop in Toronto last night
October 23, 2025 at 2:22 PM
Real data tracking my head nodding at the Autechre tour stop in Toronto last night
“What fascinated me was the fact that you could potentially predict which molecule could have this effect using thermodynamic principles in silica” www.fiercebiotech.com/special-repo...
September 22, 2025 at 1:39 PM
“What fascinated me was the fact that you could potentially predict which molecule could have this effect using thermodynamic principles in silica” www.fiercebiotech.com/special-repo...
"We discovered a TfR1-targeted brain shuttle, check out the brain uptake" (Crook et al. 2020, doi.org/10.1016/j.jm...). "This radioligand does not efficiently cross the blood-brain barrier" (Lin et al. 2025, doi.org/10.1007/s002...)
August 12, 2025 at 1:30 PM
"We discovered a TfR1-targeted brain shuttle, check out the brain uptake" (Crook et al. 2020, doi.org/10.1016/j.jm...). "This radioligand does not efficiently cross the blood-brain barrier" (Lin et al. 2025, doi.org/10.1007/s002...)
When will a generative model pass the "Internet Turing Test"? That is, a test subject cannot distinguish an AI-generated internet from the real internet.
August 8, 2025 at 1:30 PM
When will a generative model pass the "Internet Turing Test"? That is, a test subject cannot distinguish an AI-generated internet from the real internet.
Scientists: answering the questions we were dying to know, but too afraid to ask
The physical consequences of sperm gigantism https://www.biorxiv.org/content/10.1101/2025.07.19.665658v1
July 24, 2025 at 12:53 PM
Scientists: answering the questions we were dying to know, but too afraid to ask
There's a form of "Personal Computer" Stockholm syndrome where an accumulation of weird tech issues makes computer use border on torture, with a surprising user tolerance threshold. Usually it's only identified by a 3rd party using your machine and remarking... "How the heck do you use this thing?"
July 16, 2025 at 7:15 PM
There's a form of "Personal Computer" Stockholm syndrome where an accumulation of weird tech issues makes computer use border on torture, with a surprising user tolerance threshold. Usually it's only identified by a 3rd party using your machine and remarking... "How the heck do you use this thing?"
"The Illiad" is kinda like "Three-Body Problem" in that their both about vengeful omnipresent beings fucking around with physics on earth.
July 10, 2025 at 10:06 PM
"The Illiad" is kinda like "Three-Body Problem" in that their both about vengeful omnipresent beings fucking around with physics on earth.
Sequence logo's are so underutilized, even in protein design papers. Mainly because all the libraries to create them have zero imagination for applications. Represent ensembles of any residue-level property with symbol/color, or use pos/neg enrichment to show differential bias between any two sets!
July 10, 2025 at 6:59 PM
Sequence logo's are so underutilized, even in protein design papers. Mainly because all the libraries to create them have zero imagination for applications. Represent ensembles of any residue-level property with symbol/color, or use pos/neg enrichment to show differential bias between any two sets!
Grant me the confidence of a scientist asking for help installing software in the Boltz2 webinar Zoom chat
June 18, 2025 at 12:23 PM
Grant me the confidence of a scientist asking for help installing software in the Boltz2 webinar Zoom chat
Increasingly convinced there's collusion in "big spinach" to sell washed leaves "wet" in grocery store tubs to accelerate rot and increase sales 🤫🥬💧🤑
June 7, 2025 at 5:04 PM
Increasingly convinced there's collusion in "big spinach" to sell washed leaves "wet" in grocery store tubs to accelerate rot and increase sales 🤫🥬💧🤑
leetspeak still alive in the bioinformatics community, academic.oup.com/nar/advance-...
M1CR0B1AL1Z3R 2.0: an enhanced web server for comparative analysis of bacterial genomes at scale
academic.oup.com
May 14, 2025 at 12:58 PM
leetspeak still alive in the bioinformatics community, academic.oup.com/nar/advance-...
Kinda like mining bitcoin
ALICE detects the conversion of lead into gold at the LHC
Near-miss collisions between high-energy lead nuclei at the #LHC generate intense electromagnetic fields that can knock out protons and transform lead into fleeting quantities of gold nuclei
Find out more: home.cern/news/news/ph...
Near-miss collisions between high-energy lead nuclei at the #LHC generate intense electromagnetic fields that can knock out protons and transform lead into fleeting quantities of gold nuclei
Find out more: home.cern/news/news/ph...
May 8, 2025 at 10:57 PM
Kinda like mining bitcoin
Love and respect the four-digit PDB code convention, and will miss it. I like how you can use it to roughly "date" structures. Like, 3J5P as a marker for the start of the cryo-EM membrane protein era in 2013.
May 6, 2025 at 8:20 PM
Love and respect the four-digit PDB code convention, and will miss it. I like how you can use it to roughly "date" structures. Like, 3J5P as a marker for the start of the cryo-EM membrane protein era in 2013.
As if the big scientific publishers weren't bad enough, they sometimes just take journals offline. "Current Opinion in Drug Discovery & Development" ran from 1998-2010. Owned by Thomson but almost all links are broken with no other hosts (that I can tell), pubmed.ncbi.nlm.nih.gov?term=%22Curr...
May 5, 2025 at 10:38 PM
As if the big scientific publishers weren't bad enough, they sometimes just take journals offline. "Current Opinion in Drug Discovery & Development" ran from 1998-2010. Owned by Thomson but almost all links are broken with no other hosts (that I can tell), pubmed.ncbi.nlm.nih.gov?term=%22Curr...
Biology is hard example #103342: "Our in vivo screening efforts confirmed the requirement for high-affinity binding of the ligand for the cognate receptor to achieve robust activity" (*whisper* R^2 of 0.14) academic.oup.com/nar/article/...
May 2, 2025 at 8:36 PM
Biology is hard example #103342: "Our in vivo screening efforts confirmed the requirement for high-affinity binding of the ligand for the cognate receptor to achieve robust activity" (*whisper* R^2 of 0.14) academic.oup.com/nar/article/...
Pharma: "Drug discovery is so hard, we have great binders but they fail in preclinical and clinical research"
AI Drug Discovery companies: "So... if we make better binders all diseases will be cured?"
AI Drug Discovery companies: "So... if we make better binders all diseases will be cured?"
April 24, 2025 at 6:36 PM
Pharma: "Drug discovery is so hard, we have great binders but they fail in preclinical and clinical research"
AI Drug Discovery companies: "So... if we make better binders all diseases will be cured?"
AI Drug Discovery companies: "So... if we make better binders all diseases will be cured?"
Oral-B Pro 1000 and Philips Sonicare 4100 are the canonical "best electric toothbrushes", but they are really different UX. Philips brush size and vibration is so small it's basically regular brushing with a buzz, but with the Oral-B its truly elevated brushing on easy mode (not a paid advert!)
April 18, 2025 at 3:19 PM
Oral-B Pro 1000 and Philips Sonicare 4100 are the canonical "best electric toothbrushes", but they are really different UX. Philips brush size and vibration is so small it's basically regular brushing with a buzz, but with the Oral-B its truly elevated brushing on easy mode (not a paid advert!)
Academic in Bio ML: "Oh rats, my inverse design sequence recovery metric is really poor on this complex... better lower the temperature."
Biotech patent: "In some embodiments, our claim is the endogenous ligand and anything over 20% identity. Trust me look at all these sequences we generated."
Biotech patent: "In some embodiments, our claim is the endogenous ligand and anything over 20% identity. Trust me look at all these sequences we generated."
April 8, 2025 at 10:03 PM
Academic in Bio ML: "Oh rats, my inverse design sequence recovery metric is really poor on this complex... better lower the temperature."
Biotech patent: "In some embodiments, our claim is the endogenous ligand and anything over 20% identity. Trust me look at all these sequences we generated."
Biotech patent: "In some embodiments, our claim is the endogenous ligand and anything over 20% identity. Trust me look at all these sequences we generated."
In the zone. Completely in sync with the universe. Measured the same weight on my digital scale 3 days in a row. That's even harder than losing or gaining weight 👏👏
April 4, 2025 at 4:09 PM
In the zone. Completely in sync with the universe. Measured the same weight on my digital scale 3 days in a row. That's even harder than losing or gaining weight 👏👏
How many yogurt lid related cuts go unreported each year due to shame/disgrace? Destigmatize yogurt lid related injury and hold the diary industry accountable.
April 2, 2025 at 8:05 PM
How many yogurt lid related cuts go unreported each year due to shame/disgrace? Destigmatize yogurt lid related injury and hold the diary industry accountable.
It's probably been said before, but random Reddit comments with like 1 upvote have a lot of power for specific recommendations. For example, trip planning: city A vs B, or hotel A vs B. Is there any better source of "truth" than these anecdotes? They can rank high on search, pretty empowering...
March 27, 2025 at 6:10 PM
It's probably been said before, but random Reddit comments with like 1 upvote have a lot of power for specific recommendations. For example, trip planning: city A vs B, or hotel A vs B. Is there any better source of "truth" than these anecdotes? They can rank high on search, pretty empowering...
"I'll be candid: by now you know I care about you personally, but I need to challenge you directly so my behavior doesn't come across as ruinously empathetic or obnoxiously aggressive. Really, it's the only way I can give you feedback so I can sincerely manipulate. Do you have any feedback on that?"
March 27, 2025 at 4:35 PM
"I'll be candid: by now you know I care about you personally, but I need to challenge you directly so my behavior doesn't come across as ruinously empathetic or obnoxiously aggressive. Really, it's the only way I can give you feedback so I can sincerely manipulate. Do you have any feedback on that?"