Jared Mayers, MD, PhD
@jrmayers.bsky.social
Assistant Professor at Fred Hutchinson Cancer Center and PCCM doc
Studying metabolism in diseases caused by microbes
research.fredhutch.org/mayers/en.html
Studying metabolism in diseases caused by microbes
research.fredhutch.org/mayers/en.html
Reposted by Jared Mayers, MD, PhD
Next, our 2nd preprint of the week (!), this one driven by @madelouhart.bsky.social
Previously: Mitochondrial inhibition impairs cell proliferation by constraining aspartate (ASP) availability.
Here: we investigate the kinetics of ASP depletion/ proliferation impairments and...surprises ensue!
Previously: Mitochondrial inhibition impairs cell proliferation by constraining aspartate (ASP) availability.
Here: we investigate the kinetics of ASP depletion/ proliferation impairments and...surprises ensue!
Succinate Dehydrogenase loss causes cascading metabolic effects that impair pyrimidine biosynthesis https://www.biorxiv.org/content/10.1101/2025.02.18.638948v1
February 20, 2025 at 10:25 PM
Next, our 2nd preprint of the week (!), this one driven by @madelouhart.bsky.social
Previously: Mitochondrial inhibition impairs cell proliferation by constraining aspartate (ASP) availability.
Here: we investigate the kinetics of ASP depletion/ proliferation impairments and...surprises ensue!
Previously: Mitochondrial inhibition impairs cell proliferation by constraining aspartate (ASP) availability.
Here: we investigate the kinetics of ASP depletion/ proliferation impairments and...surprises ensue!
Reposted by Jared Mayers, MD, PhD
Excited to share a recent preprint by Oliver Newsom, where we evaluate the functional contributions of serum for cancer cell proliferation. Inside:
A broadly applicable serum-free media,
Quantitative lipid uptake characterization,
Evidence lipid scavenging > synthesis for cancer cell proliferation.
A broadly applicable serum-free media,
Quantitative lipid uptake characterization,
Evidence lipid scavenging > synthesis for cancer cell proliferation.
Defined media reveals the essential role of lipid scavenging to support cancer cell proliferation https://www.biorxiv.org/content/10.1101/2025.02.12.637975v1
February 20, 2025 at 2:43 AM
Excited to share a recent preprint by Oliver Newsom, where we evaluate the functional contributions of serum for cancer cell proliferation. Inside:
A broadly applicable serum-free media,
Quantitative lipid uptake characterization,
Evidence lipid scavenging > synthesis for cancer cell proliferation.
A broadly applicable serum-free media,
Quantitative lipid uptake characterization,
Evidence lipid scavenging > synthesis for cancer cell proliferation.
Reposted by Jared Mayers, MD, PhD
🧪 Ready, set, degrade!
So proud to share our work in the @jclinical-invest.bsky.social, establishing a versatile approach for creating transgenic dTAG mice to degrade oncoproteins. We showcase that KRAS G12V degradation triggers antitumor immunity in lung cancer.
Link: www.jci.org/articles/vie...
So proud to share our work in the @jclinical-invest.bsky.social, establishing a versatile approach for creating transgenic dTAG mice to degrade oncoproteins. We showcase that KRAS G12V degradation triggers antitumor immunity in lung cancer.
Link: www.jci.org/articles/vie...
December 27, 2024 at 5:04 PM
🧪 Ready, set, degrade!
So proud to share our work in the @jclinical-invest.bsky.social, establishing a versatile approach for creating transgenic dTAG mice to degrade oncoproteins. We showcase that KRAS G12V degradation triggers antitumor immunity in lung cancer.
Link: www.jci.org/articles/vie...
So proud to share our work in the @jclinical-invest.bsky.social, establishing a versatile approach for creating transgenic dTAG mice to degrade oncoproteins. We showcase that KRAS G12V degradation triggers antitumor immunity in lung cancer.
Link: www.jci.org/articles/vie...
Reposted by Jared Mayers, MD, PhD
It's estimated that around 13% of cancers overall are caused by infections.
This is an area where prevention can be very powerful: by tackling the infections that cause them, we can stop these cancers before they start. 🧵
This is an area where prevention can be very powerful: by tackling the infections that cause them, we can stop these cancers before they start. 🧵
December 20, 2024 at 11:11 AM
It's estimated that around 13% of cancers overall are caused by infections.
This is an area where prevention can be very powerful: by tackling the infections that cause them, we can stop these cancers before they start. 🧵
This is an area where prevention can be very powerful: by tackling the infections that cause them, we can stop these cancers before they start. 🧵
Reposted by Jared Mayers, MD, PhD
Many people talk about the "Golden Age of Antibiotics", but I hadn't seen it visualized properly.
Just how many types of antibiotics were discovered during that time?
So, I visualized it myself!
Just how many types of antibiotics were discovered during that time?
So, I visualized it myself!
December 23, 2024 at 10:09 AM
Many people talk about the "Golden Age of Antibiotics", but I hadn't seen it visualized properly.
Just how many types of antibiotics were discovered during that time?
So, I visualized it myself!
Just how many types of antibiotics were discovered during that time?
So, I visualized it myself!
Reposted by Jared Mayers, MD, PhD
Very glad to see this properly out and open access from my time with @baym.lol We've learnt so much about antibiotic resistance evolution already, and yet so many outstanding and fascinating questions remain, at all levels of selection.
www.annualreviews.org/content/jour...
www.annualreviews.org/content/jour...
November 22, 2024 at 8:46 AM
Very glad to see this properly out and open access from my time with @baym.lol We've learnt so much about antibiotic resistance evolution already, and yet so many outstanding and fascinating questions remain, at all levels of selection.
www.annualreviews.org/content/jour...
www.annualreviews.org/content/jour...
Reposted by Jared Mayers, MD, PhD
More #NatureReviewsCancer updates 🚨
We recently launched a collection on the #microbiome in cancer. While its role is still debated, the collection presents a selection of articles from #SpringerNature journals to highlight our current understandings.🧫🦠
😀👉 bit.ly/48u8WFH
We recently launched a collection on the #microbiome in cancer. While its role is still debated, the collection presents a selection of articles from #SpringerNature journals to highlight our current understandings.🧫🦠
😀👉 bit.ly/48u8WFH
The microbiome in cancer
The gut microbiome plays a crucial role in cancer development and progression, by influencing the host immune system and metabolism.
www.nature.com
November 22, 2024 at 11:18 AM
More #NatureReviewsCancer updates 🚨
We recently launched a collection on the #microbiome in cancer. While its role is still debated, the collection presents a selection of articles from #SpringerNature journals to highlight our current understandings.🧫🦠
😀👉 bit.ly/48u8WFH
We recently launched a collection on the #microbiome in cancer. While its role is still debated, the collection presents a selection of articles from #SpringerNature journals to highlight our current understandings.🧫🦠
😀👉 bit.ly/48u8WFH