Jean-Philippe Leduc-Gaudet
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jpleduc-gaudet.bsky.social
Jean-Philippe Leduc-Gaudet
@jpleduc-gaudet.bsky.social
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Scientist
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Reposted by Jean-Philippe Leduc-Gaudet
vincentmarcangeli.bsky.social
Strength training improves mitochondrial bioenergetics and skeletal muscle integrity in women with Myotonic Dystrophy Type 1.

Thanks to everyone involved, notably @gillesgouspillou.bsky.social, @jpleduc-gaudet.bsky.social, E. Duchesne, L. Girard-Coté.

onlinelibrary.wiley.com/doi/10.1111/...
A 12‐Week Strength Training Improves Mitochondrial Respiration, H2O2 Emission and Skeletal Muscle Integrity in Women With Myotonic Dystrophy Type 1
Background Myotonic dystrophy type 1 (DM1) is caused by expanded CTG repeats in the DMPK gene, causing the accumulation of toxic RNA that sequesters RNA-binding proteins. Clinically, DM1 is characte.....
onlinelibrary.wiley.com
November 18, 2025 at 9:14 PM
Reposted by Jean-Philippe Leduc-Gaudet
vincentmarcangeli.bsky.social
When studying mitochondria, it is essential to consider the impact of physical activity. Some findings attributed to 'aging' might actually be the result of decades of physical inactivity. ⬇️

www.cell.com/cell-reports...
Impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in men
Cefis et al. show that mitochondrial respiration and ROS production are not affected during healthy muscle aging but identify altered mitochondrial calcium handling as a potential key driving mechanis...
www.cell.com
February 11, 2025 at 7:18 PM