Joe Loparo
@joeloparo.bsky.social
Professor of Biological Chemistry & Molecular Pharmacology @HMS using single-molecule approaches to understand biological mechanism. DSB repair, TLS and bacterial cell wall
Thanks Michael. I decided to share because I think it is important that people know what is happening.
May 21, 2025 at 2:46 AM
Thanks Michael. I decided to share because I think it is important that people know what is happening.
www.biorxiv.org
December 24, 2024 at 3:32 AM
Or two recent preprints: www.biorxiv.org/content/10.1...
MreC-MreD structure reveals a multifaceted interface that controls MreC conformation
The peptidoglycan (PG) cell wall is critical for bacterial growth and survival and is a primary antibiotic target. MreD is an essential accessory factor of the Rod complex, which carries out PG synthe...
www.biorxiv.org
December 24, 2024 at 3:32 AM
Or two recent preprints: www.biorxiv.org/content/10.1...
You can learn more about her work by checking out: www.nature.com/articles/s41...
Allosteric activation of cell wall synthesis during bacterial growth - Nature Communications
Coordination of cell wall assembly is critical for bacterial morphology and survival. Here, the authors show that activation of cell wall synthesis by the Rod complex is regulated by the structural dy...
www.nature.com
December 24, 2024 at 3:17 AM
You can learn more about her work by checking out: www.nature.com/articles/s41...
Employing single-molecule, genetic and protein engineering approaches Irina has shown how structural dynamics induced by essential regulating factors activate these machines so that their activities are productive and are not wasteful.
December 24, 2024 at 3:13 AM
Employing single-molecule, genetic and protein engineering approaches Irina has shown how structural dynamics induced by essential regulating factors activate these machines so that their activities are productive and are not wasteful.