Jared M. Cole
@jmillercole.bsky.social
PhD Candidate in the Kirkpatrick and Harpak Labs at UT Austin. Research in evolution, population genetics, and sex differences.
Excited to share our new preprint from the @arbelharpak.bsky.social Lab!
How do recruitment into genetic studies and study characteristics impact what we infer about the genetic bases of traits, and what are the consequences? (1/21)
www.biorxiv.org/content/10.6...
How do recruitment into genetic studies and study characteristics impact what we infer about the genetic bases of traits, and what are the consequences? (1/21)
www.biorxiv.org/content/10.6...
Representation in genetic studies affects inference about genetic architecture
Knowledge of a trait's "genetic architecture," namely the joint distribution of allele frequencies of causal variants and the direction and magnitude of their effects, is essential to understanding it...
www.biorxiv.org
January 14, 2026 at 7:07 PM
Excited to share our new preprint from the @arbelharpak.bsky.social Lab!
How do recruitment into genetic studies and study characteristics impact what we infer about the genetic bases of traits, and what are the consequences? (1/21)
www.biorxiv.org/content/10.6...
How do recruitment into genetic studies and study characteristics impact what we infer about the genetic bases of traits, and what are the consequences? (1/21)
www.biorxiv.org/content/10.6...
Reposted by Jared M. Cole
I’m very excited to share our new preprint with @arbelharpak.bsky.social! We meta-analyze male-female allele frequency divergences across studies (gnomAD, UKB, AoU) and ask what drives the observed differences. (1/12)
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
January 7, 2026 at 9:33 PM
I’m very excited to share our new preprint with @arbelharpak.bsky.social! We meta-analyze male-female allele frequency divergences across studies (gnomAD, UKB, AoU) and ask what drives the observed differences. (1/12)
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Jared M. Cole
I am excited to share the first first-author paper of my PhD describing work with Changde Cheng, Mark Kirkpatrick and @arbelharpak.bsky.social has been published at AJHG! We ask if sex-differential gene expression drives sex-differential selection in humans. (1/14)
www.cell.com/ajhg/fulltex...
www.cell.com/ajhg/fulltex...
No evidence for sex-differential transcriptomes driving genome-wide sex-differential natural selection
We assess the evidence for a genome-wide relationship between sex differences in gene
expression and sex differences in natural selection. We develop an improved model
for testing this association but...
www.cell.com
January 14, 2025 at 10:35 PM
I am excited to share the first first-author paper of my PhD describing work with Changde Cheng, Mark Kirkpatrick and @arbelharpak.bsky.social has been published at AJHG! We ask if sex-differential gene expression drives sex-differential selection in humans. (1/14)
www.cell.com/ajhg/fulltex...
www.cell.com/ajhg/fulltex...