Joshua Mcbee
@jkmcbee.bsky.social
LCMS weirdo. Pretend expert in all things charged or separated. Biking aficionado, coffee enthusiast, destroyer of mass spectrometers.
Great shot! Where did you take this picture? It reminds me of some of the lava tubes we used to explore in and around the bend Oregon area when I was younger.
November 25, 2025 at 1:19 AM
Great shot! Where did you take this picture? It reminds me of some of the lava tubes we used to explore in and around the bend Oregon area when I was younger.
I think they just created a big box o’ ions that they can eject when they are ready.
September 11, 2025 at 12:35 AM
I think they just created a big box o’ ions that they can eject when they are ready.
Perhaps it’s time we hold the stir bar stationary and rotate the reaction flask instead?
September 4, 2025 at 10:28 PM
Perhaps it’s time we hold the stir bar stationary and rotate the reaction flask instead?
We don’t know what the risk of this modification is but we tested Ozempic as well and it was well within the guidelines of manufacturing peptide drugs.
Beware of these pharmacies offering “cheap” GLP-1s. You don’t always know what
You are going to get.
www.linkedin.com/posts/joshua...
Beware of these pharmacies offering “cheap” GLP-1s. You don’t always know what
You are going to get.
www.linkedin.com/posts/joshua...
If you have a prescription for Ozempic, its tempting to save money by buying Semaglutide from a compounding pharmacy, but you should know the risks. | Josh McBee, M.S., Ph.D.
If you have a prescription for Ozempic, its tempting to save money by buying Semaglutide from a compounding pharmacy, but you should know the risks.
Recently we demonstrated a rapid LCMS assay using ...
www.linkedin.com
August 15, 2025 at 11:30 PM
We don’t know what the risk of this modification is but we tested Ozempic as well and it was well within the guidelines of manufacturing peptide drugs.
Beware of these pharmacies offering “cheap” GLP-1s. You don’t always know what
You are going to get.
www.linkedin.com/posts/joshua...
Beware of these pharmacies offering “cheap” GLP-1s. You don’t always know what
You are going to get.
www.linkedin.com/posts/joshua...
Semaglutide as well. With the explosion of compounding GLP-1s we wanted to see if improper handling would create this modification. We “obtained” a syringe of compounded Semaglutide and sure enough the modification shows up at about 1.5% relative to the FLP which exceeds FDA guidelines.
August 15, 2025 at 11:30 PM
Semaglutide as well. With the explosion of compounding GLP-1s we wanted to see if improper handling would create this modification. We “obtained” a syringe of compounded Semaglutide and sure enough the modification shows up at about 1.5% relative to the FLP which exceeds FDA guidelines.
Was sensitive to formaldehyde and could cyclize and this was noticed with interaction to certain excipients. We developed a quick assay for monitoring this modification. But we wanted to see if Semaglutide was sensitive to this modification too. Sure enough, exposure to formaldehyde modified
August 15, 2025 at 11:30 PM
Was sensitive to formaldehyde and could cyclize and this was noticed with interaction to certain excipients. We developed a quick assay for monitoring this modification. But we wanted to see if Semaglutide was sensitive to this modification too. Sure enough, exposure to formaldehyde modified
Is the report $2500?
July 14, 2025 at 10:18 PM
Is the report $2500?
Perhaps a bit too obscure…
The Dune
“Oh hai Duncan!”
The Dune
“Oh hai Duncan!”
July 9, 2025 at 6:00 PM
Perhaps a bit too obscure…
The Dune
“Oh hai Duncan!”
The Dune
“Oh hai Duncan!”
Delaware pickleball is vicious man.
June 20, 2025 at 4:06 PM
Delaware pickleball is vicious man.
“The gorillas will freeze to death in the winter!”
May 28, 2025 at 6:03 PM
“The gorillas will freeze to death in the winter!”
I feel like time of flight is a valid approach here. Maybe a bunch of trampolines for multi reflectron.
May 27, 2025 at 12:29 PM
I feel like time of flight is a valid approach here. Maybe a bunch of trampolines for multi reflectron.
The progress in drugs for treating cardiovascular disease over the last 5 years alone is remarkable. Drugs like Repatha and Leqvio virtually halt plaque deposition. The current guidelines for someone with CVD are to have your LDL-C below your HDL.
May 21, 2025 at 9:44 PM
The progress in drugs for treating cardiovascular disease over the last 5 years alone is remarkable. Drugs like Repatha and Leqvio virtually halt plaque deposition. The current guidelines for someone with CVD are to have your LDL-C below your HDL.
Many of the original Stephen King adaptations
Firestarter
Christine
The Dead zone
And Cujo scared the bejesus out of me as a kid
Firestarter
Christine
The Dead zone
And Cujo scared the bejesus out of me as a kid
May 17, 2025 at 11:09 PM
Many of the original Stephen King adaptations
Firestarter
Christine
The Dead zone
And Cujo scared the bejesus out of me as a kid
Firestarter
Christine
The Dead zone
And Cujo scared the bejesus out of me as a kid
Also Prince of Darkness is pretty solid 80’s horror
May 17, 2025 at 11:06 PM
Also Prince of Darkness is pretty solid 80’s horror
Was thinking the original Cronenberg.
May 17, 2025 at 11:06 PM
Was thinking the original Cronenberg.
“It takes two to lie Marge, one to lie and one to listen!”
May 12, 2025 at 2:25 PM
“It takes two to lie Marge, one to lie and one to listen!”
Achieve mystical levels of proteome coverage!
May 7, 2025 at 7:29 PM
Achieve mystical levels of proteome coverage!
Putting in a vote for Orbitrap Astral Plane…
May 7, 2025 at 7:25 PM
Putting in a vote for Orbitrap Astral Plane…
Two fistfuls of Dollars.
May 5, 2025 at 12:46 PM
Two fistfuls of Dollars.
4020: the year we made contact…and charged them for it.
May 5, 2025 at 12:40 PM
4020: the year we made contact…and charged them for it.