Jonathan Kagan
@jkagan1.bsky.social
Scientist at Boston Children's Hospital, Professor at Harvard Medical School, Husband, Father
A must read for anyone interested in inflammasome biology.
November 10, 2025 at 10:06 PM
A must read for anyone interested in inflammasome biology.
This paper validates the original work establishing this concept for the cGAS-STING pathway. Kudos to the authors.
@wyssinstitute.bsky.social
journals.asm.org/doi/10.1128/...
@wyssinstitute.bsky.social
journals.asm.org/doi/10.1128/...
mRNAs encoding self-DNA reactive cGAS enhance the immunogenicity of lipid nanoparticle vaccines | mBio
Nucleic acid-based vaccines hold promise in preventing infections and treating cancer.
The most common use of this technology is to encode antigenic proteins on mRNAs that
are delivered to cells via l...
journals.asm.org
November 4, 2025 at 3:31 PM
This paper validates the original work establishing this concept for the cGAS-STING pathway. Kudos to the authors.
@wyssinstitute.bsky.social
journals.asm.org/doi/10.1128/...
@wyssinstitute.bsky.social
journals.asm.org/doi/10.1128/...
Notably, WTA is not a PAMP.
Rather, WTA controls the release of bacterial DNA into cells, where it can act as a PAMP for AIM2 and cGAS. How many other meta-PAMPs are out there?
@jordanjastrab.bsky.social @harvardmed.bsky.social @bostonchildrens.bsky.social @harvardmicro.bsky.social
Rather, WTA controls the release of bacterial DNA into cells, where it can act as a PAMP for AIM2 and cGAS. How many other meta-PAMPs are out there?
@jordanjastrab.bsky.social @harvardmed.bsky.social @bostonchildrens.bsky.social @harvardmicro.bsky.social
September 26, 2025 at 2:02 PM
Notably, WTA is not a PAMP.
Rather, WTA controls the release of bacterial DNA into cells, where it can act as a PAMP for AIM2 and cGAS. How many other meta-PAMPs are out there?
@jordanjastrab.bsky.social @harvardmed.bsky.social @bostonchildrens.bsky.social @harvardmicro.bsky.social
Rather, WTA controls the release of bacterial DNA into cells, where it can act as a PAMP for AIM2 and cGAS. How many other meta-PAMPs are out there?
@jordanjastrab.bsky.social @harvardmed.bsky.social @bostonchildrens.bsky.social @harvardmicro.bsky.social
Original report on the regulators of TLR4 endocytosis and its importance in TRIF-IFN signaling.
@lozanzi.bsky.social @harvardmed.bsky.social @harvardmicro.bsky.social
www.cell.com/fulltext/S00...
@lozanzi.bsky.social @harvardmed.bsky.social @harvardmicro.bsky.social
www.cell.com/fulltext/S00...
CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4
The pattern recognition receptor CD14 not only delivers bacterial lipopolysaccharide
to TLR4 on the plasma membrane of dendritic cells but also regulates TLR4 endocytosis
and trafficking to the endoso...
www.cell.com
September 19, 2025 at 12:44 PM
Original report on the regulators of TLR4 endocytosis and its importance in TRIF-IFN signaling.
@lozanzi.bsky.social @harvardmed.bsky.social @harvardmicro.bsky.social
www.cell.com/fulltext/S00...
@lozanzi.bsky.social @harvardmed.bsky.social @harvardmicro.bsky.social
www.cell.com/fulltext/S00...
September 19, 2025 at 12:44 PM
This work derives from prior studies on the structure-function relationship between Bacteroides LPS and TLR4 endocytosis and signaling.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Mechanisms of Toll-like Receptor 4 Endocytosis Reveal a Common Immune-Evasion Strategy Used by Pathogenic and Commensal Bacteria
Microbe-induced receptor trafficking has emerged as an essential means to promote innate immune signal transduction. Upon detection of bacterial lipop…
www.sciencedirect.com
September 19, 2025 at 12:44 PM
This work derives from prior studies on the structure-function relationship between Bacteroides LPS and TLR4 endocytosis and signaling.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...