Jacques Fattaccioli
@jfattaccioli.bsky.social
Microfluidics • Soft matter • Cells
Ass. Pr. at Sorbonne U. / ENS-PSL and IPGG
Maker of chips, droplets, and tools for curious biology.
Homepage : https://fattaccioli.github.io
Ass. Pr. at Sorbonne U. / ENS-PSL and IPGG
Maker of chips, droplets, and tools for curious biology.
Homepage : https://fattaccioli.github.io
Reposted by Jacques Fattaccioli
Inside macrophages, the particles report the onset and progression of phagosomal acidification at single-object resolution.
This work is a collaboration with B. Dumat and J.M. Mallet (ENS-PSL, Chemistry Dpt) and @florenceniedergang.bsky.social (Institut Cochin)
This work is a collaboration with B. Dumat and J.M. Mallet (ENS-PSL, Chemistry Dpt) and @florenceniedergang.bsky.social (Institut Cochin)
November 20, 2025 at 5:17 PM
Inside macrophages, the particles report the onset and progression of phagosomal acidification at single-object resolution.
This work is a collaboration with B. Dumat and J.M. Mallet (ENS-PSL, Chemistry Dpt) and @florenceniedergang.bsky.social (Institut Cochin)
This work is a collaboration with B. Dumat and J.M. Mallet (ENS-PSL, Chemistry Dpt) and @florenceniedergang.bsky.social (Institut Cochin)
Each particle carries pH-responsive BODIPY dyes on its surface and a stable reference probe in the core, enabling ratiometric readouts. By decorating the membrane with Fcγ-binding ligands, we drive controlled uptake and capture the earliest steps of phagosome formation.
November 20, 2025 at 5:17 PM
Each particle carries pH-responsive BODIPY dyes on its surface and a stable reference probe in the core, enabling ratiometric readouts. By decorating the membrane with Fcγ-binding ligands, we drive controlled uptake and capture the earliest steps of phagosome formation.
A collaboration between Alexandre Chargueraud, graduate student in our team (fattaccioli.github.io) and Lars Kool from the IPGG Microfabrication facility (www.plateformeipgg.fr). This work has been presented at the Micro and Nano Engineering (MNE) conference in 2024.
Jacques Fattaccioli Microfluidics & Soft Matter
Official website of Jacques Fattaccioli, Professor in Chemistry at Sorbonne Université. Research in microfluidics, soft matter, biophysics, and biotech innovation.
fattaccioli.github.io
November 20, 2025 at 5:02 PM
A collaboration between Alexandre Chargueraud, graduate student in our team (fattaccioli.github.io) and Lars Kool from the IPGG Microfabrication facility (www.plateformeipgg.fr). This work has been presented at the Micro and Nano Engineering (MNE) conference in 2024.
We also built a Python/μManager interface that automates trapping, imaging, motion control, and bubble-free priming steps. The result is a robust, fully automated platform for high-throughput single-object studies, from screening assays to mechanobiology and dynamic imaging workflows.
November 20, 2025 at 5:02 PM
We also built a Python/μManager interface that automates trapping, imaging, motion control, and bubble-free priming steps. The result is a robust, fully automated platform for high-throughput single-object studies, from screening assays to mechanobiology and dynamic imaging workflows.
Confocal measurements reveal clear pressure-dependent deformation profiles, in excellent agreement with a thick-membrane model. Controlled fluidic and pneumatic actuation enables rapid, fully reversible trapping within seconds.
November 20, 2025 at 5:02 PM
Confocal measurements reveal clear pressure-dependent deformation profiles, in excellent agreement with a thick-membrane model. Controlled fluidic and pneumatic actuation enables rapid, fully reversible trapping within seconds.
Et le fait que globalement ça marche plus mal que les solution GAFAM.
November 2, 2025 at 6:50 PM
Et le fait que globalement ça marche plus mal que les solution GAFAM.
Et la plupart des solutions institutionnelles ne font clairement pas la comparaison, entre le fait que chacun fait des trucs dans son coin. Pour l'écriture partagée, il y sDrive, Resana etc etc.
November 2, 2025 at 6:49 PM
Et la plupart des solutions institutionnelles ne font clairement pas la comparaison, entre le fait que chacun fait des trucs dans son coin. Pour l'écriture partagée, il y sDrive, Resana etc etc.
J'ai lu ton article dans le Monde. Je suis d'accord (comment ne pas l'être). Toutefois c'est très difficile sans supports techniques d'aller contre les GAFAM. Et des supports techniques il n'y en a point ou plus.
November 2, 2025 at 5:46 PM
J'ai lu ton article dans le Monde. Je suis d'accord (comment ne pas l'être). Toutefois c'est très difficile sans supports techniques d'aller contre les GAFAM. Et des supports techniques il n'y en a point ou plus.
The issue should still be there I guess :-)
August 9, 2025 at 7:18 AM
The issue should still be there I guess :-)
Still running ?
August 8, 2025 at 11:28 AM
Still running ?
Félicitations !
March 29, 2025 at 2:58 PM
Félicitations !