Jonas Sauer
@jf-sauer.bsky.social
Neuroscientist, Professor of Physiology; interest in learning, memory & network function.
Fantastic symposium on circuit function last week here at CIPMM. Thanks to our guests Kristina Lippmann, Magdalene Schlesiger, Fiona Muellner and @juliaveit.bsky.social for sharing their latest on synaptic function, interneuron & pyramidal cell networks and long-range communication.
June 2, 2025 at 2:32 PM
Fantastic symposium on circuit function last week here at CIPMM. Thanks to our guests Kristina Lippmann, Magdalene Schlesiger, Fiona Muellner and @juliaveit.bsky.social for sharing their latest on synaptic function, interneuron & pyramidal cell networks and long-range communication.
Reposted by Jonas Sauer
See below for the latest results from the lab! Led by @susannebabl.bsky.social with support from @dfg.de and @for5159.bsky.social
The last part of my PhD with @torfisigurdsson.bsky.social is now published in @plosbiology.org
journals.plos.org/plosbiology/...
We looked at the interaction of the hippocampus and prefrontal cortex during spatial working memory when mice were navigating a T-maze, using ephys and optogenetics 🧠🐭
journals.plos.org/plosbiology/...
We looked at the interaction of the hippocampus and prefrontal cortex during spatial working memory when mice were navigating a T-maze, using ephys and optogenetics 🧠🐭
The dorsal and ventral hippocampus contribute differentially to spatial working memory and spatial coding in the prefrontal cortex
The hippocampus and prefrontal cortex interact to support spatial working memory, but are the dorsal and ventral hippocampus functionally redundant in this context? This study shows that both hippocam...
journals.plos.org
April 24, 2025 at 12:54 PM
See below for the latest results from the lab! Led by @susannebabl.bsky.social with support from @dfg.de and @for5159.bsky.social
Reposted by Jonas Sauer
Engaging poster session at the IN-Code retreat. Thanks to our SAB members and all researchers of the CRC for their interest! All students did a great job presenting their projects. @mbartos.bsky.social @uni-freiburg.de @biologyunifreiburg.bsky.social
April 10, 2025 at 8:42 PM
Engaging poster session at the IN-Code retreat. Thanks to our SAB members and all researchers of the CRC for their interest! All students did a great job presenting their projects. @mbartos.bsky.social @uni-freiburg.de @biologyunifreiburg.bsky.social
New paper out! We found functional neuron classes in the mPFC with different spatial tuning properties (generalised vs. trajectory-specific) and distinct contribution to the encoding of task space. Great job by the first author Hannah!
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Conjoint generalized and trajectory-specific coding of task structure by prefrontal neurons
Neurons in the medial prefrontal cortex (mPFC) show spatially modulated activities.
Muysers et al. show that mPFC neurons fall into distinct functional classes that differ
in terms of their spatial tu...
www.cell.com
March 11, 2025 at 10:47 AM
New paper out! We found functional neuron classes in the mPFC with different spatial tuning properties (generalised vs. trajectory-specific) and distinct contribution to the encoding of task space. Great job by the first author Hannah!
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Representational drift in CA1? We find hidden features of stability in the internal geometry of population activity, which might help to maintain a stable downstream readout. Now preprinted thanks to a great collaboration w/ @olechsylte.bsky.social , @antjekilias.bsky.social and Marlene Bartos. 👇
Stable maps from drifting neurons: CA1 solves the "representational drift paradox" through coordinated population dynamics.
New preprint w/ @antjekilias.bsky.social , Marlene Bartos and @jf-sauer.bsky.social showing that representational drift isn’t random—it’s structured to preserve information🧵👇
New preprint w/ @antjekilias.bsky.social , Marlene Bartos and @jf-sauer.bsky.social showing that representational drift isn’t random—it’s structured to preserve information🧵👇
Coordinated representational drift supports stable place coding in hippocampal CA1
The phenomenon of representational drift (i.e., changing neuronal tuning during repeated exposure to the same stimuli), is a fundamental paradox in neuroscience that raises the question how stable beh...
www.biorxiv.org
February 5, 2025 at 9:31 AM
Representational drift in CA1? We find hidden features of stability in the internal geometry of population activity, which might help to maintain a stable downstream readout. Now preprinted thanks to a great collaboration w/ @olechsylte.bsky.social , @antjekilias.bsky.social and Marlene Bartos. 👇
Reposted by Jonas Sauer
Our new preprint on long-term low-frequency stimulation in MTLE is online. We show that LFS has lasting effects on seizures even during stimulation-free periods and induces ultrastructural changes at the PP synapse.
Long-term hippocampal low-frequency stimulation alleviates focal seizures, memory deficits and synaptic pathology in epileptic mice https://www.biorxiv.org/content/10.1101/2025.01.16.633322v1
January 20, 2025 at 10:07 AM
Our new preprint on long-term low-frequency stimulation in MTLE is online. We show that LFS has lasting effects on seizures even during stimulation-free periods and induces ultrastructural changes at the PP synapse.
I am honoured to join Saarland University as Professor of Physiology in February 2025. My department will focus on the network mechanisms of learning, with particular interest in synaptic function & computations of large neuronal populations. We are hiring, so feel free to get in touch!
January 16, 2025 at 11:46 AM
I am honoured to join Saarland University as Professor of Physiology in February 2025. My department will focus on the network mechanisms of learning, with particular interest in synaptic function & computations of large neuronal populations. We are hiring, so feel free to get in touch!