Jessica Sacher
@jessicasacher.bsky.social
phage therapy scientist at Stanford, building community at Phage Directory, writing about adventures from the lab to the clinic -> https://jess.bio
Oh also find John Rex here! @johnhrexmd.bsky.social
December 11, 2024 at 6:01 PM
Oh also find John Rex here! @johnhrexmd.bsky.social
6/ The solution? We need new models that pay for ACCESS, not USAGE
Think Netflix subscription > pay per view
Read the full analysis by @JohnRex_NewAbx: https://amr.solutions/2024/10/14/plazomicin-achaogen-financial-post-mortem-passpasteur/
/end
Think Netflix subscription > pay per view
Read the full analysis by @JohnRex_NewAbx: https://amr.solutions/2024/10/14/plazomicin-achaogen-financial-post-mortem-passpasteur/
/end
Plazomicin (Achaogen) financial post-mortem: #PassPASTEUR
Dear All (and with thanks to Kevin for co-authoring and also a wonkish alert … get your coffee and settle in for the details), If you’ve been around the antibiotic ecosystem for a while, you’ve hopefully heard the story of the 2019 bankruptcy of Achaogen and the subsequent loss to the entire world of its […]
13.43.35.2
December 11, 2024 at 5:58 PM
6/ The solution? We need new models that pay for ACCESS, not USAGE
Think Netflix subscription > pay per view
Read the full analysis by @JohnRex_NewAbx: https://amr.solutions/2024/10/14/plazomicin-achaogen-financial-post-mortem-passpasteur/
/end
Think Netflix subscription > pay per view
Read the full analysis by @JohnRex_NewAbx: https://amr.solutions/2024/10/14/plazomicin-achaogen-financial-post-mortem-passpasteur/
/end
5/ Why this matters for scientists:
We're not just losing drugs. We're losing the teams who know how to make them.
Talent is leaving the field. (The true cost of broken incentives)
We're not just losing drugs. We're losing the teams who know how to make them.
Talent is leaving the field. (The true cost of broken incentives)
December 11, 2024 at 5:58 PM
5/ Why this matters for scientists:
We're not just losing drugs. We're losing the teams who know how to make them.
Talent is leaving the field. (The true cost of broken incentives)
We're not just losing drugs. We're losing the teams who know how to make them.
Talent is leaving the field. (The true cost of broken incentives)
4/ The hidden tragedy: Plazomicin still WORKS. It could save lives.
But without a company behind it = limited global access
Like having a fire extinguisher no one can buy 🧯
But without a company behind it = limited global access
Like having a fire extinguisher no one can buy 🧯
December 11, 2024 at 5:58 PM
4/ The hidden tragedy: Plazomicin still WORKS. It could save lives.
But without a company behind it = limited global access
Like having a fire extinguisher no one can buy 🧯
But without a company behind it = limited global access
Like having a fire extinguisher no one can buy 🧯
3/ The painful numbers from @JohnRex_NewAbx's analysis:
- $500-600M to reach approval
- +$350M to keep it on market 10yrs
- Expected sales? Minimal
Because good stewardship = less use = bankruptcy 🤯
- $500-600M to reach approval
- +$350M to keep it on market 10yrs
- Expected sales? Minimal
Because good stewardship = less use = bankruptcy 🤯
December 11, 2024 at 5:58 PM
3/ The painful numbers from @JohnRex_NewAbx's analysis:
- $500-600M to reach approval
- +$350M to keep it on market 10yrs
- Expected sales? Minimal
Because good stewardship = less use = bankruptcy 🤯
- $500-600M to reach approval
- +$350M to keep it on market 10yrs
- Expected sales? Minimal
Because good stewardship = less use = bankruptcy 🤯
2/ The developer's paradox: "Make something AMAZING... that we hope rarely gets used"
Investors: "So we spend millions to create a drug that sits on a shelf?"
Scientists: "Yes! That's the point!"
Investors: *leaves chat*
Investors: "So we spend millions to create a drug that sits on a shelf?"
Scientists: "Yes! That's the point!"
Investors: *leaves chat*
December 11, 2024 at 5:58 PM
2/ The developer's paradox: "Make something AMAZING... that we hope rarely gets used"
Investors: "So we spend millions to create a drug that sits on a shelf?"
Scientists: "Yes! That's the point!"
Investors: *leaves chat*
Investors: "So we spend millions to create a drug that sits on a shelf?"
Scientists: "Yes! That's the point!"
Investors: *leaves chat*
1/ The Achaogen story haunts scientists:
- Spent 9 years developing plazomicin
- Got FDA approval in 2018
- Raised $776M (!!)
- Bankrupt by 2019
- Sold for pennies: $16M
The math wasn't mathing 📉
- Spent 9 years developing plazomicin
- Got FDA approval in 2018
- Raised $776M (!!)
- Bankrupt by 2019
- Sold for pennies: $16M
The math wasn't mathing 📉
December 11, 2024 at 5:58 PM
1/ The Achaogen story haunts scientists:
- Spent 9 years developing plazomicin
- Got FDA approval in 2018
- Raised $776M (!!)
- Bankrupt by 2019
- Sold for pennies: $16M
The math wasn't mathing 📉
- Spent 9 years developing plazomicin
- Got FDA approval in 2018
- Raised $776M (!!)
- Bankrupt by 2019
- Sold for pennies: $16M
The math wasn't mathing 📉
Or really anyone. Awesome read
December 9, 2024 at 5:56 PM
Or really anyone. Awesome read
Wonderful thank you! I will post this in Capsid & Tail this week and see who else we can bring on over!
November 13, 2024 at 7:13 PM
Wonderful thank you! I will post this in Capsid & Tail this week and see who else we can bring on over!
Reposted by Jessica Sacher
Welcome! I created the account a while ago but paying attention since yesterday. I have found three phage phlocks so far:
1. #phagesky list
2. Starter pack bsky.app/starter-pack...
3. Starter pack bsky.app/starter-pack...
1. #phagesky list
2. Starter pack bsky.app/starter-pack...
3. Starter pack bsky.app/starter-pack...
November 13, 2024 at 6:48 PM
Welcome! I created the account a while ago but paying attention since yesterday. I have found three phage phlocks so far:
1. #phagesky list
2. Starter pack bsky.app/starter-pack...
3. Starter pack bsky.app/starter-pack...
1. #phagesky list
2. Starter pack bsky.app/starter-pack...
3. Starter pack bsky.app/starter-pack...
I just joined also! Apparently the party has been here?!
November 13, 2024 at 6:39 PM
I just joined also! Apparently the party has been here?!