Statistical assessment of score uncertainty is also becoming especially critical as DMS experiments scale to more conditions, phenotypes, and proteins. We hope Lilace will help address these challenges and enable more reliable functional interpretation of FACS-based DMS data! (3/3)
June 30, 2025 at 4:03 PM
Statistical assessment of score uncertainty is also becoming especially critical as DMS experiments scale to more conditions, phenotypes, and proteins. We hope Lilace will help address these challenges and enable more reliable functional interpretation of FACS-based DMS data! (3/3)
Coupling DMS experiments with FACS enables simultaneous measurement of a quantitative phenotype (e.g. protein abundance) across thousands of mutations in a protein. However, modeling FACS as a phenotype can be challenging due to its unique multidimensional nature and experimental noise. (2/3)
June 30, 2025 at 4:03 PM
Coupling DMS experiments with FACS enables simultaneous measurement of a quantitative phenotype (e.g. protein abundance) across thousands of mutations in a protein. However, modeling FACS as a phenotype can be challenging due to its unique multidimensional nature and experimental noise. (2/3)