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jcellsci.bsky.social
Journal of Cell Science
@jcellsci.bsky.social
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Journal of Cell Science (JCS) publishes cutting-edge science encompassing all aspects of cell biology. JCS is a community journal published by The Company of Biologists (@biologists.bsky.social), a not-for-profit organisation. #cellbiology #cellbio
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jcellsci.bsky.social
Mole's Comedia III. Purgatorio. Canto I–XXIV.

journals.biologists.com/jcs/article/...
Drawing of an anthropomorphised Mole in a robe next to a figure with robes and a crown. ‘Beings’ in a ditch are holding out sheets of paper to Mole. The location looks creepy. The text below the image says, ‘We land, and I see hundreds of like souls. Holding manuscripts in clenched hands… “It is nearly ready” he say…’
November 21, 2025 at 2:01 PM
jcellsci.bsky.social
In this Hypothesis, Panagiotis Giannios discusses how endocrine control might modulate mRNA fate through ribonucleoprotein granules that can send reciprocal feedback to hormonal circuits, adding flexibility to gene regulation.

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This simplified schematic illustrates how RNPGs could integrate hormonal cues to regulate mRNA fate. (A) Hormonal inputs activate intracellular pathways that modify RBPs through non-genomic mechanisms or alter RBP levels via transcriptional regulation. These changes modulate granule assembly, leading to context-specific outcomes. (B) Granules act as hubs where mRNAs are selectively sequestered, released for translation or targeted for decay, and can process multiple converging signals using logic-like behaviour. (C) Feedback from granule activity, including via the regulation of hormone receptor transcripts, further influences hormonal responsiveness. Collectively, this model positions RNPGs as signal-processing platforms that decode combinatorial hormonal inputs into precise post-transcriptional outcomes. Figure created in BioRender by Giannios, P., 2025. https://BioRender.com/u2uavov. This figure was sublicensed under CC-BY 4.0 terms.
November 21, 2025 at 10:00 AM
jcellsci.bsky.social
Also in Issue 21:
- Research Highlights on force transduction and lipid metabolism
- Mole's Comedia III
- A tribute to Günther Gerisch
- A Hypothesis article on hormones and RNP granules
- Sphingolipids and methionine metabolism Review
journals.biologists.com/jcs/issue/13...
Model for Mup1-mediated regulation of lifespan in response to SL synthesis.
November 20, 2025 at 2:08 PM
jcellsci.bsky.social
Issue 21 is complete

Explore our ToC: journals.biologists.com/jcs/issue/13...

On the cover: a lattice-like network of actomyosin filaments in a cell under fluid shear stress with NM-MyoIIA in yellow & actin in blue. See article by Mallick et al.
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JCS cover with a super-resolution image of an MDA-MB-231 cell under fluid shear stress, showing a lattice-like network of orthogonally aligned stacks of non-muscle myosin IIA minifilaments (yellow) with parallel actin bundles (blue), counterstained with DAPI to label the nucleus (magenta).
November 20, 2025 at 2:08 PM
jcellsci.bsky.social
Yubo Zou, Deborah Leckband and colleagues find that EGFR is an essential component in E-cadherin force transduction complexes.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
#OpenAccess #ReadandPublish
Figure showing that uncoupling E-cadherin–EGFR complexes disrupts tension-dependent proliferation in dense epithelial cultures.
November 20, 2025 at 10:03 AM
jcellsci.bsky.social
Tomoya Hotani, Yuki Ohsaki, Wataru Sakai & team discover that FANCD2 responds to both DNA damage & oleic acid exposure, providing insights into the pathogenesis of lipid dysregulation in Fanconi anemia.
Highlight: journals.biologists.com/jcs/article/...

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Figure showing OA-induced nLD localization of FANCI.
November 19, 2025 at 10:02 AM
jcellsci.bsky.social
Read more about this research in our ‘First person’ interview with Dushyant Gautam: journals.biologists.com/jcs/article/...
Dushyant Gautam
November 18, 2025 at 9:01 AM
jcellsci.bsky.social
Dushyant Gautam, Indira Paddibhatla and colleagues find that methotrexate alleviates chronic inflammation in a Drosophila model.
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Figure showing the effect of methotrexate on Toll pathway induced by Lb-17 parasitoid wasp infestation.
November 18, 2025 at 9:01 AM
jcellsci.bsky.social
In their Perspective article, Muyang Ren, Siham Jaleel, Stephen King & Girish Mali @dyneinassembly.bsky.social highlight the structural diversity of the axonemal dynein assembly factors & their emerging roles in the biology of motile cilia.
#JCSciliaSI
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Schematic of the dynein assembly pathway and putative roles of DNAAFs that work within it. Axonemal dynein arm motor subunits (heavy chains, intermediate chains and light chains) are assembled in a multi-step dynein assembly pathway involving steps of folding, assembly and transport. DNAAFs are thought to operate at distinct steps. HSP70 proteins likely engage nascent dynein heavy chain, intermediate chain and light chain subunits as they emerge from the ribosome exit tunnel. Specific DNAAFs then likely hand over semi-folded subunits to the HSP90 chaperone and its co-chaperone R2TP complex for further folding and assembly. Many DNAAFs are proposed to function at this step with RUVBL1/2. Pre-assembled ODA motors are finally packaged into an inhibited closed conformation by DNAAF9 (Shulin) for stable attachment to IFT trains for ciliary import. IDAs might undergo similar packaging for IFT transport via currently unknown factors. Genetic variants that block any step of assembly can cause severe motile ciliopathies such as PCD. PTM, post-translational modification.
November 17, 2025 at 12:09 PM
jcellsci.bsky.social
Read more about this research in our ‘First person’ interview with Rudolfo Karl: journals.biologists.com/jcs/article/...
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Rudolfo Karl
November 14, 2025 at 2:14 PM
jcellsci.bsky.social
Rudolfo Karl, Elvira Mass, Dagmar Wachten @wachtenlab.bsky.social and colleagues discover that renal tissue-resident macrophages promote cystogenesis in early polycystic kidney disease.
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Figure showing that tissue-resident macrophages promote cytogenesis in an in vitro 3D model system.
November 14, 2025 at 2:14 PM
jcellsci.bsky.social
We're still accepting submissions for our 'Cell Biology of the Nucleus' special issue, which is being guest edited by
@abbybuch.bsky.social and Megan King (@luskinglab.bsky.social).
Submission deadline: 5 January
journals.biologists.com/jcs/pages/nu...
#nucleus #notforprofit #freetopublish
November 13, 2025 at 5:13 PM
jcellsci.bsky.social
Read more about this research in our ‘First person’ interview with Tiago Dantas @dantas-lab.bsky.social @icvs-uminho.bsky.social: journals.biologists.com/jcs/article/...
Tiago Dantas
November 13, 2025 at 9:45 AM
jcellsci.bsky.social
Tiago Dantas @dantas-lab.bsky.social @icvs-uminho.bsky.social, Carla Abreu @carlamcabreu.bsky.social and colleagues @i3suporto.bsky.social find that dynein-2 requires HSP90 chaperone activity to ensure robust retrograde IFT and ciliogenesis.
#JCSciliaSI
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Figure showing that HSP90 inhibition results in IFT particle accumulation in the ciliary shaft due to reduced frequency of retrograde IFT.
November 13, 2025 at 9:45 AM
jcellsci.bsky.social
In their Perspective article, Ruxandra Bachmann-Gagescu, and John Sayer explore how ciliary specialisation might explain the high variability of ciliopathies and propose priority research directions.
#JCSciliaSI
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Cartoon showing organ and cell-type-specific functions and pathways of primary cilia. Here, we show examples of renal, retinal and CNS ciliated cells, indicating some of the known resident ciliary proteins required for their specific sensory function.
November 12, 2025 at 3:04 PM
jcellsci.bsky.social
Melanie Eschment, Ruxandra Bachmann-Gagescu and colleagues discover that CEP290 deficiency disrupts ciliary axonemal architecture in human iPSC-derived brain organoids.
#JCSciliaSI
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#OpenAccess #ReadandPublish
November 12, 2025 at 1:46 PM
jcellsci.bsky.social
Akisato Marumo, Hiroto Ishii, Shin Yamaguchi, Junichiro Yajima and colleagues characterise the 3D beating pattern of the ciliary tip in the live ciliate Tetrahymena.
#JCSciliaSI
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#OpenAccess #ReadandPublish
November 12, 2025 at 9:44 AM
jcellsci.bsky.social
Dagmar Wachten @wachtenlab.bsky.social & Søren Tvorup Christensen @sorentc.bsky.social explore the primary cilium as a master regulator of cellular communication that integrates diverse signalling pathways in development & homeostasis.
#JCSciliaSI
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JCS poster - Primary cilia signalling at a glance
November 11, 2025 at 3:04 PM
jcellsci.bsky.social
Melis Dalbay, Stephen Hart @ucl.ac.uk and colleagues develop and characterise a robust human PCD airway cell model via BMI1 transduction, which will enable therapeutic and mechanistic studies.
#JCSciliaSI
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November 11, 2025 at 10:27 AM
jcellsci.bsky.social
In this Opinion piece, Rachel Turn, Mohammad Ovais Aziz-Zanjani, Anushweta Asthana & Peter Jackson highlight strategies for multiplexing diverse approaches to map transient phosphorylations driving ciliary function & G0 in health versus disease.
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Graphical summary representing strategies for deciphering temporal–spatial phosphoproteomic outcomes of primary cilia signaling in different biological contexts.
November 10, 2025 at 3:03 PM
jcellsci.bsky.social
Read more about this research in our ‘First person’ interview with Mark Lee: journals.biologists.com/jcs/article/...
#JCSciliaSI
Mark Lee
November 10, 2025 at 9:01 AM
jcellsci.bsky.social
Mark Lee @guacamarklee.bsky.social and Keren Hilgendorf @uofubiochem.bsky.social discover that prostaglandin E2 inhibits adipogenesis through the cilia-dependent activation of ROCK2.
#JCSciliaSI
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Figure showing that EP4 localizes to primary cilia of ASCs.
November 10, 2025 at 9:01 AM
jcellsci.bsky.social
Miao Gui and @orbachron.bsky.social summarise current structural and functional insights into conserved and lineage-specific MIPs, their roles in shaping ciliary architecture, and the consequences of their disruption on ciliary motility.
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Conserved MIPs. (A) 16 common MIPs that are conserved across almost all examined species. (B) Cross-section view of the location of the conserved MIPs within a DMT. (C) Longitudinal view of the eight conserved MIPs at the outer junction and seam region. (D) Longitudinal view of the six conserved MIPs at the inner junction. The figures are generated based on structure of DMTs from human respiratory epithelium cilia (PDB: 8J07). Black arrow indicates the position of the seam.
November 7, 2025 at 3:02 PM
jcellsci.bsky.social
Read more about this research in our ‘First person’ interview with Alyssa Long: journals.biologists.com/jcs/article/...
#JCSciliaSI
Alyssa Long
November 7, 2025 at 1:02 PM
jcellsci.bsky.social
Alyssa Long, Tamara Caspary and colleagues discover that ARL13B-Cerulean rescues Arl13b-null mouse from embryonic lethality and uncover a role for ARL13B in spermatogenesis.
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Micrographs showing that pancreatic islets appear normal in Arl13bhnn/hnn;Arl13b-Cerulean mice.
November 7, 2025 at 1:02 PM