John Wallingford
@jbwallingford.bsky.social
SAVE THE DATE! Stoked to organize the 2026 Santa Cruz Developmental Biology Meeting with @rashmi-priya.bsky.social, @lowelab.bsky.social, and Shelbi Russell. Come learn about Biomedicine, Biomechanics, and the Biosphere, August 24-28, 2026. Registration dates, etc., coming soon! Please RT
November 19, 2025 at 8:23 PM
SAVE THE DATE! Stoked to organize the 2026 Santa Cruz Developmental Biology Meeting with @rashmi-priya.bsky.social, @lowelab.bsky.social, and Shelbi Russell. Come learn about Biomedicine, Biomechanics, and the Biosphere, August 24-28, 2026. Registration dates, etc., coming soon! Please RT
Everyone knows I suffer from Drosophila envy. I blame C.W. Woodworth. He studied the fly's embryos in W.E. Castle's lab; Castle would be the first to use them for genetics. The rest is history. Woodworth's gorgeous 1889 pictures of butterfly embryos are below. Enjoy! 1/3
@socdevbio.bsky.social
@socdevbio.bsky.social
August 14, 2025 at 3:38 PM
Everyone knows I suffer from Drosophila envy. I blame C.W. Woodworth. He studied the fly's embryos in W.E. Castle's lab; Castle would be the first to use them for genetics. The rest is history. Woodworth's gorgeous 1889 pictures of butterfly embryos are below. Enjoy! 1/3
@socdevbio.bsky.social
@socdevbio.bsky.social
Don't know about y'all, but i am not scared of AI taking over the world. At least not today.
July 17, 2025 at 2:45 PM
Don't know about y'all, but i am not scared of AI taking over the world. At least not today.
Robert's imaging in Xenopus revealed that manipulations of either PCP or cadherin reflect the model's local alignment parameter. Margot showed that spadetail mutants in zebrafish reflect the model's longer-range parameter 3/n
July 2, 2025 at 1:20 PM
Robert's imaging in Xenopus revealed that manipulations of either PCP or cadherin reflect the model's local alignment parameter. Margot showed that spadetail mutants in zebrafish reflect the model's longer-range parameter 3/n
We show that emergence of nematic order precedes cell shape changes at the start of convergent extension in all three species. Xin found that a theoretical model could only recapitulate the patterns observed in vivo if it involved both long-range and short-range cues. 2/n
July 2, 2025 at 1:20 PM
We show that emergence of nematic order precedes cell shape changes at the start of convergent extension in all three species. Xin found that a theoretical model could only recapitulate the patterns observed in vivo if it involved both long-range and short-range cues. 2/n
Neftalí demonstrated a specific role for CPLANE in recruiting a subset of transition zone proteins to the base of cilia in frog, @elleroberson.bsky.social showed the same in mice, and Thao Phan and Camille Derderian in @reitergroup.bsky.social showed it in human cells. 7/n
July 1, 2025 at 5:22 PM
Neftalí demonstrated a specific role for CPLANE in recruiting a subset of transition zone proteins to the base of cilia in frog, @elleroberson.bsky.social showed the same in mice, and Thao Phan and Camille Derderian in @reitergroup.bsky.social showed it in human cells. 7/n
With Peter Jackson's group at Stanford, we then used APMS to show that GTP-binding was essential to Rsg1 association with CPLANE and moreover that Rsg1 interacts with transition zone proteins. 6/n
July 1, 2025 at 5:22 PM
With Peter Jackson's group at Stanford, we then used APMS to show that GTP-binding was essential to Rsg1 association with CPLANE and moreover that Rsg1 interacts with transition zone proteins. 6/n
Frog work led by Neftalí Vazquez and Chanjae Lee revealed that these alleles are pathogenic, acting via distinct mechanisms to disrupt both basal body docking and recruitment of IFT-A. 5/n
July 1, 2025 at 5:22 PM
Frog work led by Neftalí Vazquez and Chanjae Lee revealed that these alleles are pathogenic, acting via distinct mechanisms to disrupt both basal body docking and recruitment of IFT-A. 5/n
Now, with a host of collaborators led by Irene Valenzuela and Eduardo Tizzano, we report three families in which variants of RSG1 causes ciliopathy. 4/n
July 1, 2025 at 5:22 PM
Now, with a host of collaborators led by Irene Valenzuela and Eduardo Tizzano, we report three families in which variants of RSG1 causes ciliopathy. 4/n
Is John doing embryology? Or genetics? Wouldn’t you like to know. 😉
June 27, 2025 at 5:24 PM
Is John doing embryology? Or genetics? Wouldn’t you like to know. 😉
Damn. I want to be a postdoc with Mansi Srivastava…. 🤯🤯🤯
@socdevbio.bsky.social
@socdevbio.bsky.social
June 20, 2025 at 11:07 PM
Damn. I want to be a postdoc with Mansi Srivastava…. 🤯🤯🤯
@socdevbio.bsky.social
@socdevbio.bsky.social
If you haven’t, you really should.
June 17, 2025 at 1:34 AM
If you haven’t, you really should.
Not sure what’s the bigger win: My son taking me to see Highlander on the big screen for Father’s Day or learning that one of the Highlanders assumed names was Wallingford. (jk, totally the first one)
June 16, 2025 at 3:44 AM
Not sure what’s the bigger win: My son taking me to see Highlander on the big screen for Father’s Day or learning that one of the Highlanders assumed names was Wallingford. (jk, totally the first one)
Hildegard’s contemporary, Rebecca de Guarana wrote an entire treatise titled “On the Embryo,” but we sadly don’t know what it said. No copies exist. Indeed, we’re lucky to have Hildegard’s embryology at all. “Causae et Curae” is known today only from a single copy made in the 13th Century. 12/16
June 11, 2025 at 1:34 AM
Hildegard’s contemporary, Rebecca de Guarana wrote an entire treatise titled “On the Embryo,” but we sadly don’t know what it said. No copies exist. Indeed, we’re lucky to have Hildegard’s embryology at all. “Causae et Curae” is known today only from a single copy made in the 13th Century. 12/16
We all know scientists who are also musicians In fact, one of my favorites just dropped a new album last month. I was surprised me, though, since she died over 800 years ago. Turns out she might also be the first woman to ever write about developmental biology. 🧵 1/16
June 11, 2025 at 1:34 AM
We all know scientists who are also musicians In fact, one of my favorites just dropped a new album last month. I was surprised me, though, since she died over 800 years ago. Turns out she might also be the first woman to ever write about developmental biology. 🧵 1/16
Totally hammering today on #1000wordsofsummer, btw. #devbiolwriteclub
June 7, 2025 at 6:33 PM
Totally hammering today on #1000wordsofsummer, btw. #devbiolwriteclub
June 1, 2025 at 6:05 PM
Woot! Only 12:41 and I've already hit my mark for Day One of #1000wordsofsummer. So, so stoked. See y'all tomorrow.
#devbiolwriteclub
#devbiolwriteclub
May 31, 2025 at 5:43 PM
Woot! Only 12:41 and I've already hit my mark for Day One of #1000wordsofsummer. So, so stoked. See y'all tomorrow.
#devbiolwriteclub
#devbiolwriteclub
Learning who my friends are….
May 13, 2025 at 12:41 AM
Learning who my friends are….
…and here is why we do this work. Graduation day! Congrats @neftaliv.bsky.social
May 10, 2025 at 4:08 PM
…and here is why we do this work. Graduation day! Congrats @neftaliv.bsky.social
For Conrad Waddington’s 50th birthday, his colleagues made him a working “epigenetic landscape pinball machine.” I learned that because I write on Saturday mornings.
May 3, 2025 at 4:21 PM
For Conrad Waddington’s 50th birthday, his colleagues made him a working “epigenetic landscape pinball machine.” I learned that because I write on Saturday mornings.
Who’s in for a sunday evening writing session? 🙋🏻♂️ (Corpse reviver #2, if you’re playing along at home.)
April 27, 2025 at 11:23 PM
Who’s in for a sunday evening writing session? 🙋🏻♂️ (Corpse reviver #2, if you’re playing along at home.)