Eddings et al. illustrate that synaptic membrane trafficking can be studied with millisecond resolution in resected human brain tissues using the technique “zap-and-freeze” time-resolved electron micr...

PU.1low CD28-expressing microglia may act as suppressive cells in Alzheimer’s disease, mitigating its progression by reducing neuroinflammation and amyloid plaque load, indicating potential immunother...

Lecanemab, a leading therapy for Alzheimer’s disease, induces an Fc-mediated transcriptional program in human microglia, linked to osteopontin and enhanced plaque phagocytosis, suggesting alternative ...

Synchronizing movements to music is a hallmark of human culture, but its evolutionary and neurobiological origins remain unknown. This ability requires (i) extracting a steady rhythmic pulse, or beat,...

Depression is a common psychiatric disorder, and increasing evidence implicates the dysregulation of extracellular ATP and hippocampal dysfunction in its pathophysiology. However, whether ATP release ...

Background Synaptic homeostasis, maintained by microglia and astroglia, is disrupted throughout aging and early on in neurodegenerative diseases. Our aim was to study the relationship between TREM2-de...

During sickness, animals exhibit prolonged social withdrawal, a response that may limit disease spread. Elevated IL-1β levels during inflammation activate IL-1R1-expressing neurons in the dorsal raphe...