Lars Jansen Lab
@jansenlab.bsky.social
Discovering Mechanisms of Chromatin Inheritance at the University of Oxford www.jansenlab.org
SETDB1, previously implicated in transposon silencing, is a novel player in maintaining heterochromatin boundaries within core alpha satellites. This regulation is critical, as loss of heterochromatin integrity results in ectopic CENP-A domains and distal centromere nucleation!
November 25, 2025 at 12:16 PM
SETDB1, previously implicated in transposon silencing, is a novel player in maintaining heterochromatin boundaries within core alpha satellites. This regulation is critical, as loss of heterochromatin integrity results in ectopic CENP-A domains and distal centromere nucleation!
A new and fascinating story from @bencarty.bsky.social and the group, with crucial help from the teams of @naltemose.bsky.social, Simona Giunta, and @dfachinetti.bsky.social. Many thanks to all for a fantastic collaboration.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 25, 2025 at 12:16 PM
A new and fascinating story from @bencarty.bsky.social and the group, with crucial help from the teams of @naltemose.bsky.social, Simona Giunta, and @dfachinetti.bsky.social. Many thanks to all for a fantastic collaboration.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The discovery of CENP-A, the centromere-specific histone H3 variant turns 40 years!
Grant Rowley wrote a wonderful historical piece on the cell cycle control of this fascinating piece of chromatin! Check it out.
link.springer.com/article/10.1...
Grant Rowley wrote a wonderful historical piece on the cell cycle control of this fascinating piece of chromatin! Check it out.
link.springer.com/article/10.1...
July 29, 2025 at 11:05 AM
The discovery of CENP-A, the centromere-specific histone H3 variant turns 40 years!
Grant Rowley wrote a wonderful historical piece on the cell cycle control of this fascinating piece of chromatin! Check it out.
link.springer.com/article/10.1...
Grant Rowley wrote a wonderful historical piece on the cell cycle control of this fascinating piece of chromatin! Check it out.
link.springer.com/article/10.1...
Fresh of the press! rdcu.be/egmY0 We discovered key chromatin modifications that are heritably maintained through mitotic cell divisions in the absence of continued transcription. These hold a memory of past exposure to interferon-gamma, priming cells for future activation of gene expression.
April 4, 2025 at 10:22 AM
Fresh of the press! rdcu.be/egmY0 We discovered key chromatin modifications that are heritably maintained through mitotic cell divisions in the absence of continued transcription. These hold a memory of past exposure to interferon-gamma, priming cells for future activation of gene expression.
@bencarty.bsky.social and the team did a fantastic job in a wonderful collaboration with @naltemose.bsky.social as well as Dani Fachinetti and Simona Giunta’s teams to help define the molecular basis for maintaining centromeric chromatin size and position. www.biorxiv.org/content/10.1...
February 5, 2025 at 5:33 PM
@bencarty.bsky.social and the team did a fantastic job in a wonderful collaboration with @naltemose.bsky.social as well as Dani Fachinetti and Simona Giunta’s teams to help define the molecular basis for maintaining centromeric chromatin size and position. www.biorxiv.org/content/10.1...
Join our team www.jansenlab.org as a @wellcometrust.bsky.social -funded postdoctoral fellow and help us discover how chromatin at human centromeres is formed and inherited. Position now open at @oxfordbiochemistry.bsky.social! See: my.corehr.com/pls/uoxrecru... for details!
December 17, 2024 at 9:19 PM
Join our team www.jansenlab.org as a @wellcometrust.bsky.social -funded postdoctoral fellow and help us discover how chromatin at human centromeres is formed and inherited. Position now open at @oxfordbiochemistry.bsky.social! See: my.corehr.com/pls/uoxrecru... for details!