Jan Hansel
@janhansel.bsky.social
NIHR Doctoral Fellow in Intensive Care Medicine
Anaesthetist and Intensivist in Training
Manchester, UK
Anaesthetist and Intensivist in Training
Manchester, UK
Especially the latter. The red herring of sepsis may expose patients to diagnostic delays, perhaps increasing their odds of a worse outcome. Not sure if this has been looked at properly.
When it comes to sepsis, we seem to be fixating on the left column (TP and FN), at the expense of the FPs.
When it comes to sepsis, we seem to be fixating on the left column (TP and FN), at the expense of the FPs.
December 11, 2024 at 8:37 PM
Especially the latter. The red herring of sepsis may expose patients to diagnostic delays, perhaps increasing their odds of a worse outcome. Not sure if this has been looked at properly.
When it comes to sepsis, we seem to be fixating on the left column (TP and FN), at the expense of the FPs.
When it comes to sepsis, we seem to be fixating on the left column (TP and FN), at the expense of the FPs.
Silly goose, it's a one-sided P value. I'll retreat to my cave.
December 10, 2024 at 12:51 PM
Silly goose, it's a one-sided P value. I'll retreat to my cave.
On an unrelated note, I asked ChatGPT to help me interpret the P value in that non-inferiority statement.
'[...] at 5.4% (19.4% [170/878] of pts receiving std care; 20.9% [184/879], PCT; abs diff, 1.57; 95% CI, −2.18 to 5.32; P = .02)'
Can someone smarter than us (GPT & me) help confirm or refute?
'[...] at 5.4% (19.4% [170/878] of pts receiving std care; 20.9% [184/879], PCT; abs diff, 1.57; 95% CI, −2.18 to 5.32; P = .02)'
Can someone smarter than us (GPT & me) help confirm or refute?
December 10, 2024 at 12:37 PM
On an unrelated note, I asked ChatGPT to help me interpret the P value in that non-inferiority statement.
'[...] at 5.4% (19.4% [170/878] of pts receiving std care; 20.9% [184/879], PCT; abs diff, 1.57; 95% CI, −2.18 to 5.32; P = .02)'
Can someone smarter than us (GPT & me) help confirm or refute?
'[...] at 5.4% (19.4% [170/878] of pts receiving std care; 20.9% [184/879], PCT; abs diff, 1.57; 95% CI, −2.18 to 5.32; P = .02)'
Can someone smarter than us (GPT & me) help confirm or refute?
I have … thoughts. Not sure what the study was actually assessing - odd primary endpoint given intervention. I wonder how robust the sample size assumptions (6% ARR) were.
But mostly just goes to show what we do peri-operatively has such a marginal effect, if any.
But mostly just goes to show what we do peri-operatively has such a marginal effect, if any.
December 3, 2024 at 6:09 PM
I have … thoughts. Not sure what the study was actually assessing - odd primary endpoint given intervention. I wonder how robust the sample size assumptions (6% ARR) were.
But mostly just goes to show what we do peri-operatively has such a marginal effect, if any.
But mostly just goes to show what we do peri-operatively has such a marginal effect, if any.
Should interim analyses in trials include subgroup assessments and adaptive response?
Baillie et al. Causal inference can lead us to modifiable mechanisms and informative archetypes in sepsis
link.springer.com/article/10.1...
Baillie et al. Causal inference can lead us to modifiable mechanisms and informative archetypes in sepsis
link.springer.com/article/10.1...
December 2, 2024 at 10:36 PM
Should interim analyses in trials include subgroup assessments and adaptive response?
Baillie et al. Causal inference can lead us to modifiable mechanisms and informative archetypes in sepsis
link.springer.com/article/10.1...
Baillie et al. Causal inference can lead us to modifiable mechanisms and informative archetypes in sepsis
link.springer.com/article/10.1...
Sometimes I wonder if jumping ship was the right decision 👀 😂
November 16, 2024 at 10:10 AM
Sometimes I wonder if jumping ship was the right decision 👀 😂
Okay here you go, a halloween cat
November 15, 2024 at 12:19 PM
Okay here you go, a halloween cat