👁‍🗨 We are seeking for a motivated and enthusiastic colleague to join our team. Do you want to know more? visit the link below ⬇️⬇️⬇️
www.radboudumc.nl/en/vacancies...

👁️‍This interdisciplinary project will combine cutting-edge stem cell technology, retinal organoid development, and genetic/functional assays to better understand patient-specific mechanisms of vision loss and pave the way for precision medicine in ophthalmology.

📰 Both papers are now out as back-to-back bioRxiv publications, reinforcing the idea that light is more than a trigger.
Thank you very much to everyone involved in this work!
#light #retinalorganoids #maturation #stemcells #photostimulation #development #photoreceptors #iPSC @radboudumc.bsky.social

⭐ We were excited to come across the work in @tomasbarta.bsky.social’s group. In the work conducted by Canan Çeliker and collaborators (www.biorxiv.org/content/10.1...), the use of flickering light for 2 weeks, revealed similar conclusions with respect the role of light in improving maturation.

Together, these results support the idea that light enhances photoreceptor maturation and could be key to improving the functionality of retinal organoids.

🔬 Interestingly, RNA and protein levels did not always correlate directly, underlining the complexity of translational regulation.
🔬 Importantly, light exposure did not induce cell death, oxidative stress, or autophagy, suggesting it is safe and potentially beneficial.

🔬 We observed earlier and higher expression of photoreceptor marker genes in the light-exposed organoids.
🔬 Proteomics analysis at the end of differentiation revealed enrichment of rod photoreceptor markers at the protein level
🔬 We observed increased number of rods by immunostaining.

In our new study (www.biorxiv.org/content/10.1...), led by Edwin van Oosten, we exposed retinal organoids to daily white light cycles throughout differentiation. Our results in a nutshell:

Congratulations Owen and many thanks to Alex and Amanda.

Nice pictures! Thanks a lot @cheethamlab.bsky.social for the nice time in London! See you in Prague!

And thanks to @amandajcarr.bsky.social for the guidance and help navigating my first viva! It was very nice to finally meeting you in person!

Congrats Owen! And of course also to you and @cheethamlab.bsky.social! He did great & we had very interesting discussions! Thanks for the invitation & thinking about me as the external expert. I really enjoyed it! It was lovely to catch up with you! Thanks a lot for the hospitality!

Also @lrdesviat.bsky.social who I could not find when I posted!

We are looking forward to start working together! Remember we are recruiting until March 15!!!📢

euraxess.ec.europa.eu/jobs/296420

The mutation at protein level, if no splicing defect would be present, would be a synonymous change. Therefore the normal protein will be produced.

📅 Deadline: March 15th 📍 Apply here: euraxess.ec.europa.eu/jobs/296420 🌍 About us: effec-dn.eu
Don't miss out—be part of groundbreaking RNA research! 🚀 #PhD #ASO #AntisenseOligonucleotides #ResearchOpportunity #EFFecT