Johan Jakobsson
@jakobssonlab.bsky.social
Transposons and heterochromatin
Reposted by Johan Jakobsson
Always a joy to join #EMBOMobileGenome -A week full of cool nature’s quirks and science along the friendliest crowd 🧬 Happy to have shared our work on ERVs in human brain evolution (talk by @jakobssonlab.bsky.social) and Parkinson’s disease (poster by yours truly) 🧠
#ASAP @jakobssonasap.bsky.social
#ASAP @jakobssonasap.bsky.social
November 7, 2025 at 11:10 AM
Always a joy to join #EMBOMobileGenome -A week full of cool nature’s quirks and science along the friendliest crowd 🧬 Happy to have shared our work on ERVs in human brain evolution (talk by @jakobssonlab.bsky.social) and Parkinson’s disease (poster by yours truly) 🧠
#ASAP @jakobssonasap.bsky.social
#ASAP @jakobssonasap.bsky.social
Reposted by Johan Jakobsson
Updated version of our preprint on how SETDB1-mediated H3K9me3 controls the expression of L1 elements in human neural progenitor cells. The new analysis in this revised version supports a role for active DNA demethylation of L1s in the absence of H3K9me3.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Loss of SETDB1-mediated H3K9me3 in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons
Heterochromatin is characterised by an inaccessibility to the transcriptional machinery and is associated with the histone mark H3K9me3. However, studying the functional consequences of heterochromati...
www.biorxiv.org
November 5, 2025 at 9:29 PM
Updated version of our preprint on how SETDB1-mediated H3K9me3 controls the expression of L1 elements in human neural progenitor cells. The new analysis in this revised version supports a role for active DNA demethylation of L1s in the absence of H3K9me3.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Updated version of our preprint on how SETDB1-mediated H3K9me3 controls the expression of L1 elements in human neural progenitor cells. The new analysis in this revised version supports a role for active DNA demethylation of L1s in the absence of H3K9me3.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Loss of SETDB1-mediated H3K9me3 in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons
Heterochromatin is characterised by an inaccessibility to the transcriptional machinery and is associated with the histone mark H3K9me3. However, studying the functional consequences of heterochromati...
www.biorxiv.org
November 5, 2025 at 9:29 PM
Updated version of our preprint on how SETDB1-mediated H3K9me3 controls the expression of L1 elements in human neural progenitor cells. The new analysis in this revised version supports a role for active DNA demethylation of L1s in the absence of H3K9me3.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Wonderful highlight of our work! 🧬
Hominoid-specific retrotransposons fuel regulatory novelty in early brain development , by @retrogenomics.bsky.social.
➡️ www.cell.com/cell-genomic...
➡️ www.cell.com/cell-genomic...
October 13, 2025 at 6:15 PM
Wonderful highlight of our work! 🧬
Reposted by Johan Jakobsson
It was fun to write this preview with Larisa Okorokova. Congrats to @jakobssonlab.bsky.social and all coauthors for this nice piece of work !
October 11, 2025 at 12:18 AM
It was fun to write this preview with Larisa Okorokova. Congrats to @jakobssonlab.bsky.social and all coauthors for this nice piece of work !
Reposted by Johan Jakobsson
Join @embl.org for this conference exploring genetic and physiological impacts of transposable elements. Virtual registration is open until October 28. Learn more at plos.io/4nuqeZA.
October 1, 2025 at 9:10 PM
Join @embl.org for this conference exploring genetic and physiological impacts of transposable elements. Virtual registration is open until October 28. Learn more at plos.io/4nuqeZA.
Todays labmeeting became a tribute to Jane Goodall. Such an outstanding role model. 🙊
October 2, 2025 at 6:06 PM
Todays labmeeting became a tribute to Jane Goodall. Such an outstanding role model. 🙊
Reposted by Johan Jakobsson
New preprint from my lab! We describe how transposable elements are activated in Parkinson’s disease, which is linked to an interferon response. We believe this study significantly advances our understanding of transposons and their role in human brains.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson's disease
Parkinson's disease (PD) is a common age-related neurodegenerative disorder involving a neuroinflammatory response, the cause of which remains unclear. Transposable elements (TE) have been linked to i...
www.biorxiv.org
September 7, 2025 at 7:59 PM
New preprint from my lab! We describe how transposable elements are activated in Parkinson’s disease, which is linked to an interferon response. We believe this study significantly advances our understanding of transposons and their role in human brains.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Johan Jakobsson
Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson's disease https://www.biorxiv.org/content/10.1101/2025.09.03.673956v1
September 7, 2025 at 8:15 PM
Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson's disease https://www.biorxiv.org/content/10.1101/2025.09.03.673956v1
New preprint from my lab! We describe how transposable elements are activated in Parkinson’s disease, which is linked to an interferon response. We believe this study significantly advances our understanding of transposons and their role in human brains.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson's disease
Parkinson's disease (PD) is a common age-related neurodegenerative disorder involving a neuroinflammatory response, the cause of which remains unclear. Transposable elements (TE) have been linked to i...
www.biorxiv.org
September 7, 2025 at 7:59 PM
New preprint from my lab! We describe how transposable elements are activated in Parkinson’s disease, which is linked to an interferon response. We believe this study significantly advances our understanding of transposons and their role in human brains.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
New collaborative paper from our lab! We developed cell-type specific transcriptional ageing clocks using snRNA-seq data from human brain.
doi.org/10.1002/advs...
doi.org/10.1002/advs...
Human Brain Cell‐Type‐Specific Aging Clocks Based on Single‐Nuclei Transcriptomics
Muralidharan and colleagues develop cell-type-specific transcriptomic aging clocks using single-nucleus RNA sequencing of human post mortem prefrontal cortex samples. These clocks accurately predict ....
doi.org
August 29, 2025 at 6:04 PM
New collaborative paper from our lab! We developed cell-type specific transcriptional ageing clocks using snRNA-seq data from human brain.
doi.org/10.1002/advs...
doi.org/10.1002/advs...
Reposted by Johan Jakobsson
Team Jakobsson gathered in southern Sweden for a few inspiring days discussing PD, transposable elements and future plans. We even squeezed in a hike and enjoyed some beautiful views ☀️🌊 @jakobssonlab.bsky.social @kirkebylab.bsky.social @mollygale.bsky.social @asapresearch.parkinsonsroadmap.org
August 27, 2025 at 4:03 PM
Team Jakobsson gathered in southern Sweden for a few inspiring days discussing PD, transposable elements and future plans. We even squeezed in a hike and enjoyed some beautiful views ☀️🌊 @jakobssonlab.bsky.social @kirkebylab.bsky.social @mollygale.bsky.social @asapresearch.parkinsonsroadmap.org
New paper from our lab! We found that LINE-1 transposons contribute to early human brain development.
Funded by @asapresearch.parkinsonsroadmap.org
www.cell.com/cell-genomic...
Funded by @asapresearch.parkinsonsroadmap.org
www.cell.com/cell-genomic...
LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development
Adami et al. demonstrate that evolutionarily young L1s are expressed in human pluripotent
stem cells and are dynamically regulated throughout neural differentiation. The study
examines the role of L1s...
www.cell.com
August 23, 2025 at 9:47 AM
New paper from our lab! We found that LINE-1 transposons contribute to early human brain development.
Funded by @asapresearch.parkinsonsroadmap.org
www.cell.com/cell-genomic...
Funded by @asapresearch.parkinsonsroadmap.org
www.cell.com/cell-genomic...
Reposted by Johan Jakobsson
first thing to share here!
excited to share lab’s first study in Parkinson’s disease revealing the prodromal vulnerability and function of the dopamine neuron subtype defined by Anxa1 expression - a specialized system controlling procedural motor learning
www.biorxiv.org/content/10.1...
excited to share lab’s first study in Parkinson’s disease revealing the prodromal vulnerability and function of the dopamine neuron subtype defined by Anxa1 expression - a specialized system controlling procedural motor learning
www.biorxiv.org/content/10.1...
Anxa1+ dopamine neuron vulnerability defines prodromal Parkinson's disease bradykinesia and procedural motor learning impairment
Progressive degeneration of dopamine neurons (DANs) defines Parkinson's disease (PD). However, the identity and function of the most vulnerable DAN populations in prodromal PD remain undefined. Here, ...
www.biorxiv.org
December 22, 2024 at 10:43 PM
first thing to share here!
excited to share lab’s first study in Parkinson’s disease revealing the prodromal vulnerability and function of the dopamine neuron subtype defined by Anxa1 expression - a specialized system controlling procedural motor learning
www.biorxiv.org/content/10.1...
excited to share lab’s first study in Parkinson’s disease revealing the prodromal vulnerability and function of the dopamine neuron subtype defined by Anxa1 expression - a specialized system controlling procedural motor learning
www.biorxiv.org/content/10.1...
Reposted by Johan Jakobsson
Very proud of this work where we define how the MORC2 ATPase directs CpG methylation of active human L1 transposons in early development.
Thanks to co-authors, funders & wonderful environment @lundstem.bsky.social
www.biorxiv.org/content/10.1...
Brief thread below (do people still do that?) 1/X
Thanks to co-authors, funders & wonderful environment @lundstem.bsky.social
www.biorxiv.org/content/10.1...
Brief thread below (do people still do that?) 1/X
MORC2 directs transcription-dependent CpG methylation of human LINE-1 transposons in early neurodevelopment
Methylation of CpG dinucleotides is essential for silencing genomic repeats such as LINE-1 retrotransposons (L1s) in the germline and soma. Evolutionarily-young L1s are transcribed in human pluripoten...
www.biorxiv.org
July 1, 2025 at 12:55 PM
Very proud of this work where we define how the MORC2 ATPase directs CpG methylation of active human L1 transposons in early development.
Thanks to co-authors, funders & wonderful environment @lundstem.bsky.social
www.biorxiv.org/content/10.1...
Brief thread below (do people still do that?) 1/X
Thanks to co-authors, funders & wonderful environment @lundstem.bsky.social
www.biorxiv.org/content/10.1...
Brief thread below (do people still do that?) 1/X
Reposted by Johan Jakobsson
#TransposonDay2025 New manuscript from our center to which we contributed. Great work led by @chdouse.bsky.social ! Provides a mechanistic explanation for how L1s are silenced during early human development.
doi.org/10.1101/2025...
doi.org/10.1101/2025...
doi.org
June 16, 2025 at 3:47 PM
#TransposonDay2025 New manuscript from our center to which we contributed. Great work led by @chdouse.bsky.social ! Provides a mechanistic explanation for how L1s are silenced during early human development.
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Reposted by Johan Jakobsson
🧬🌽 Happy Transposon Day! 🌽🧬
Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025
Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025
June 16, 2025 at 3:14 PM
🧬🌽 Happy Transposon Day! 🌽🧬
Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025
Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025
#TransposonDay2025 New manuscript from our center to which we contributed. Great work led by @chdouse.bsky.social ! Provides a mechanistic explanation for how L1s are silenced during early human development.
doi.org/10.1101/2025...
doi.org/10.1101/2025...
doi.org
June 16, 2025 at 3:47 PM
#TransposonDay2025 New manuscript from our center to which we contributed. Great work led by @chdouse.bsky.social ! Provides a mechanistic explanation for how L1s are silenced during early human development.
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Reposted by Johan Jakobsson
A 🧵 to walk those interested through this paper...
Online now at @cp-cell.bsky.social , the culmination of a 12-year effort. 🧵 to follow later this evening
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Repeat-element RNAs integrate a neuronal growth circuit
SINEs of recovery: A subset of small RNAs encoded by repetitive genomic elements are
induced by nerve lesion to regulate protein synthesis and enhance axonal growth.
www.cell.com
May 16, 2025 at 4:50 PM
A 🧵 to walk those interested through this paper...
Reposted by Johan Jakobsson
New preprint of @trono-lab.bsky.social and my PhD work!
By modulating SWI/SNF remodeling at ancient transposable elements - LINE/L2s and SINE/MIRs, a "noncanonical" KZFP called ZNF436 protects cardiomyocytes from losing their identity.
🫀heartbeat on 🔁 repeat
www.biorxiv.org/content/10.1... #TEsky
By modulating SWI/SNF remodeling at ancient transposable elements - LINE/L2s and SINE/MIRs, a "noncanonical" KZFP called ZNF436 protects cardiomyocytes from losing their identity.
🫀heartbeat on 🔁 repeat
www.biorxiv.org/content/10.1... #TEsky
May 19, 2025 at 2:01 PM
New preprint of @trono-lab.bsky.social and my PhD work!
By modulating SWI/SNF remodeling at ancient transposable elements - LINE/L2s and SINE/MIRs, a "noncanonical" KZFP called ZNF436 protects cardiomyocytes from losing their identity.
🫀heartbeat on 🔁 repeat
www.biorxiv.org/content/10.1... #TEsky
By modulating SWI/SNF remodeling at ancient transposable elements - LINE/L2s and SINE/MIRs, a "noncanonical" KZFP called ZNF436 protects cardiomyocytes from losing their identity.
🫀heartbeat on 🔁 repeat
www.biorxiv.org/content/10.1... #TEsky
Reposted by Johan Jakobsson
Good times in Lund 🇸🇪 with @jakobssonlab.bsky.social. Beautiful campus, great food, and awesome science! Thanks Johan!
May 15, 2025 at 8:38 PM
Good times in Lund 🇸🇪 with @jakobssonlab.bsky.social. Beautiful campus, great food, and awesome science! Thanks Johan!
We had a fantastic guest speaker at our lab meeting this week who talked about the beautiful life of transposons and how they contributed to the evolution of the vertebrate brain. Thanks for the visit @cedricfeschotte.bsky.social !!
May 16, 2025 at 10:07 AM
We had a fantastic guest speaker at our lab meeting this week who talked about the beautiful life of transposons and how they contributed to the evolution of the vertebrate brain. Thanks for the visit @cedricfeschotte.bsky.social !!
Reposted by Johan Jakobsson
I am thrilled to share our preprint where we take advantage of the unique opportunities offered by human blastoids to uncover a human-specific mechanism potentially playing a role in preimplantation 🧵. www.biorxiv.org/content/10.1...
May 12, 2025 at 8:25 PM
I am thrilled to share our preprint where we take advantage of the unique opportunities offered by human blastoids to uncover a human-specific mechanism potentially playing a role in preimplantation 🧵. www.biorxiv.org/content/10.1...