Jeff Goldstein
@jagstein.bsky.social
Northwestern, placenta pathology, machine learning, infections in pregnancy, not giving medical advice, available for media
Reading "We", Orwell before Orwell. People living in glass houses. Wall around the city gives shades of Divergent
November 30, 2025 at 6:40 PM
Reading "We", Orwell before Orwell. People living in glass houses. Wall around the city gives shades of Divergent
Still life with Zebra Mussels, Chicago
September 24, 2025 at 3:12 PM
Still life with Zebra Mussels, Chicago
8 dug a 🎮-shaped hole at the beach and demanded I show bluesky
July 11, 2025 at 1:25 AM
8 dug a 🎮-shaped hole at the beach and demanded I show bluesky
Geometry diagram in the skies above Chicago
July 3, 2025 at 1:44 PM
Geometry diagram in the skies above Chicago
Mushrooms from Mammoth Cave National Park
March 27, 2025 at 5:53 PM
Mushrooms from Mammoth Cave National Park
Hourly weather with lots of details?
March 5, 2025 at 4:28 PM
Hourly weather with lots of details?
Reviewing a proposal for a colleague yesterday, "don't summon the casual interference police!!" Who are the casual inference police?
February 25, 2025 at 2:46 PM
Reviewing a proposal for a colleague yesterday, "don't summon the casual interference police!!" Who are the casual inference police?
Now rereading: blitzed, the History of drugs and the third Reich.
February 19, 2025 at 1:32 PM
Now rereading: blitzed, the History of drugs and the third Reich.
Two vessel umbilical cord. One artery, one vein (normal 2 arteries). Seen in ~1% of pregnancies, most often an isolated finding, but there may be associated genitourinary abnormalities. #placentapath
February 12, 2025 at 2:23 PM
Two vessel umbilical cord. One artery, one vein (normal 2 arteries). Seen in ~1% of pregnancies, most often an isolated finding, but there may be associated genitourinary abnormalities. #placentapath
From "Would you rather" copyright 2003: would you rather have to use a calculator that makes a mistake once every 50 computations OR do all the calculations by hand?
February 4, 2025 at 11:12 PM
From "Would you rather" copyright 2003: would you rather have to use a calculator that makes a mistake once every 50 computations OR do all the calculations by hand?
I pay attention to the vascular smooth muscle nuclei. This vessel was from the same section and shows intact nuclei, supporting that the thrombus above is pre-mortem.
January 29, 2025 at 2:49 PM
I pay attention to the vascular smooth muscle nuclei. This vessel was from the same section and shows intact nuclei, supporting that the thrombus above is pre-mortem.
What am I looking for in the umbilical cord? Adherent thrombus. Loss of endothelium, some layering of fibrin. This finding is sufficient to explain a demise.
January 29, 2025 at 2:49 PM
What am I looking for in the umbilical cord? Adherent thrombus. Loss of endothelium, some layering of fibrin. This finding is sufficient to explain a demise.
Compare & contrast with hemosiderin, which is chunkier and more reliably brown. Iron stain can help you, but not all heme breakdown products will stain(!)
January 29, 2025 at 1:22 AM
Compare & contrast with hemosiderin, which is chunkier and more reliably brown. Iron stain can help you, but not all heme breakdown products will stain(!)
What am I looking for in #placenta membranes: meconium -laden macrophages. Orangey / brownish foamy material in macrophages. The foaminess is more reliable than the color (poop is different colors(!))
January 29, 2025 at 1:22 AM
What am I looking for in #placenta membranes: meconium -laden macrophages. Orangey / brownish foamy material in macrophages. The foaminess is more reliable than the color (poop is different colors(!))
What am I looking for in the placental membranes? Chronic deciduitis with plasma cells (cdpc). Usually lymphocytic background. For me, you must have plasma cells - some places will call it if there are "enough" lymphs.
January 27, 2025 at 9:44 PM
What am I looking for in the placental membranes? Chronic deciduitis with plasma cells (cdpc). Usually lymphocytic background. For me, you must have plasma cells - some places will call it if there are "enough" lymphs.
MIR stage 3 - chorioamnionitis with amnion necrosis. Can still have line amnion cells... Criteria are thickened basement membrane or neutrophil karyorrhexis. Highest risk of neonatal sepsis.
January 23, 2025 at 6:05 PM
MIR stage 3 - chorioamnionitis with amnion necrosis. Can still have line amnion cells... Criteria are thickened basement membrane or neutrophil karyorrhexis. Highest risk of neonatal sepsis.
Maternal inflammatory response stage 2, acute chorioamnionitis - more than a few neutrophils in the fibrous chorion and amnion. I need to see subchorio as well.
January 23, 2025 at 6:05 PM
Maternal inflammatory response stage 2, acute chorioamnionitis - more than a few neutrophils in the fibrous chorion and amnion. I need to see subchorio as well.
Maternal inflammatory response in #placenta membranes. Stage 1, subchorionitis. At least a few neutrophils lining up below the fibrous chorion
January 23, 2025 at 6:05 PM
Maternal inflammatory response in #placenta membranes. Stage 1, subchorionitis. At least a few neutrophils lining up below the fibrous chorion
But pd.datetime >>> dt
January 19, 2025 at 4:02 PM
But pd.datetime >>> dt
Placental Pathology in fetal demise: cytomegalovirus (CMV). Infectious villitis. Plasma cells and calcifications significantly more frequent than in VUE. May see inclusions. CMV IHC is diagnostic.
January 16, 2025 at 2:34 PM
Placental Pathology in fetal demise: cytomegalovirus (CMV). Infectious villitis. Plasma cells and calcifications significantly more frequent than in VUE. May see inclusions. CMV IHC is diagnostic.
Placental Pathology in stillbirth - retro placental hemorrhage / hematoma, suggestive of abruption. Micro shows nasal plate disruption, fibrin, and villous infarction
January 10, 2025 at 2:28 PM
Placental Pathology in stillbirth - retro placental hemorrhage / hematoma, suggestive of abruption. Micro shows nasal plate disruption, fibrin, and villous infarction
Placental Pathology in fetal demise: immune hydrops. Massively elevated nucleated red blood cells in the fetal circulation. Rare erythroblasts were noted.
January 8, 2025 at 2:40 PM
Placental Pathology in fetal demise: immune hydrops. Massively elevated nucleated red blood cells in the fetal circulation. Rare erythroblasts were noted.