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Journal of the American Chemical Society (JACS)
@jacs.acspublications.org
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Research, news, and information from the Journal of the American Chemical Society: pubs.acs.org/JACS
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Journal of the American Chemical Society (JACS) @jacs.acspublications.org · Mar 21
We are now LIVE on #ChemSky – joining @pubs.acs.org, @acs.org, and @cenmag.bsky.social!

Follow us for the latest significant research from the world’s preeminent journal of chemistry and interfacing areas of science.

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Scientists in #JACS may have discovered a new antibiotic that’s 100x more potent against superbugs, an exciting breakthrough recently referenced by The Telegraph.

Explore the research: buff.ly/Ml3LhXR
"Discovery of Late Intermediates in Methylenomycin Biosynthesis Active against Drug-Resistant Gram-Positive Bacterial Pathogens", published in JACS
November 21, 2025 at 4:04 PM
jacs.acspublications.org
‘A Universal Solid Reaction Enabling Nanosized Li2S in an Amorphous Matrix for All-Solid-State Li–S Batteries', featured in the latest issue of #JACS!

Explore the research behind the art: buff.ly/e8hA8lV
Supplementary Cover of JACS Vol 147/Issue 46 Week Commencing November 17, 2025
November 21, 2025 at 1:01 PM
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‘Targeted RNA Degradation via LipoSM-RiboTAC Nanoparticles: A Versatile Platform for Cancer Therapy', featured in this week's #JACS!

Explore the research behind the art: buff.ly/laN5SCA
Supplementary Cover of JACS Vol 147/Issue 46 Week Commencing November 17, 2025
November 20, 2025 at 1:01 PM
jacs.acspublications.org
‘Ultrasound-Activatable Lipid Nanoplatform for Region-Confined Innate Immune Stimulation and mRNA Vaccination Therapy of Cancer’ has made the front cover of this week’s #JACS!

Explore the research behind the art: buff.ly/xL077cJ
Front Cover of JACS Vol 147/Issue 46 Week Commencing November 17, 2025
November 19, 2025 at 1:00 PM
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Check out another supplementary cover from the latest issue of #JACS: "A Structurally Robust Phospholipid Microtube Constructed by Membrane Phase Separation as a Scaffold for On-Tube Characterization of Membrane-Bound Proteins"

Discover the research behind the art 🔗: buff.ly/VP0ULDm
JACS Supplementary Cover Volume 147, Issue 45 Week Commencing Nov 10
November 18, 2025 at 2:03 PM
Reposted by Journal of the American Chemical Society (JACS)
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Chemists discovered a powerful hidden antibiotic that’s 100 times stronger than existing ones and effective against deadly superbugs.

The study has been published in the Journal of the American Chemical Society. YES, it is PEER-REVIEWED.
• pubs.acs.org/doi/10.1021/...

🧪🧵⬇️
Summary A team of scientists discovered a hidden antibiotic 100 times stronger than existing drugs against deadly superbugs like MRSA. The molecule had been overlooked for decades in a familiar bacterium. It shows no signs of resistance so far, offering hope in the fight against drug-resistant infections and paving the way for new approaches to antibiotic discovery. Abstract The methylenomycins are highly functionalized cyclopentanone antibiotics produced by Streptomyces coelicolor A3(2). A biosynthetic pathway to the methylenomycins has been proposed based on sequence analysis of the proteins encoded by the methylenomycin biosynthetic gene cluster and the incorporation of labeled precursors. However, the roles played by putative biosynthetic enzymes remain experimentally uninvestigated. Here, the biosynthetic functions of enzymes encoded by mmyD, mmyO, mmyF, and mmyE were investigated by creating in-frame deletions in each gene and investigating the effect on methylenomycin production. No methylenomycin-related metabolites were produced by the mmyD mutant, consistent with the proposed role of MmyD in an early biosynthetic step. The production of methylenomycin A, but not methylenomycin C, was abolished in the mmyF and mmy mutants, consistent with the corresponding enzymes catalyzing the epoxidation of methylenomycin C, as previously proposed. Expression of mmyF and mmyo in a S. coelicolor M145 derivative engineered to express mmr, which confers methylenomycin resistance, enabled the resulting strain to convert methylenomycin C to methylenomycin A, confirming this hypothesis. A novel metabolite (premethylenomycin C), which readily cyclizes to form the corresponding butanolide (premethylenomycin C lactone), accumulated in the mmyE mutant, indicating the corresponding enzyme is involved in introducing the exomethylene group into methylenomycin C. Remarkably, both premethylenomycin C and its lactone precursor were one to two orders of magnitude more active against various Gram-positive bacteria, including antibiotic-resistant Staphylococcus aureus and Enterococcus faecium isolates, than methylenomycins A and C, providing a promising starting point for the development of novel antibiotics to combat antimicrobial resistance. Graphical Abstract
November 16, 2025 at 7:32 PM
Reposted by Journal of the American Chemical Society (JACS)
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THIS IS HUGE! Researchers have just identified a powerful new antibiotic that is 100x STRONGER than existing drugs against deadly superbugs like MRSA and VRE. Hiding in a well-known soil bacterium, pre-methylenomycin C lactone KILLS drug-resistant bacteria WITHOUT triggering resistance.
November 16, 2025 at 7:30 PM
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Check out this supplementary cover from the latest issue of #JACS: "Boosting Thermoelectric Properties of High-Entropy Chalcogenides through Local Structural Distortion and Tailored Chemical Bonding"

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JACS Supplementary Cover Volume 147, Issue 45 Week Commencing Nov 10
November 17, 2025 at 2:02 PM
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Another supplementary cover from this week's #JACS: "From Transient to Metastable: Generation, Characterization, and Biomimetic Reactivity Studies of Well-Defined Heme Peroxynitrite Model Systems"

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JACS Supplementary Cover Volume 147, Issue 45 Week Commencing Nov 10
November 14, 2025 at 2:02 PM
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Celebrating 150 years of ACS and chemical discovery, the #ACS150 JACS Symposium Series: CSJ Spring Meeting arrives in Funabashi, Japan.

The event will be presented in English.

Apply to attend this free, in-person event on 18 March 2026: buff.ly/Y6bK3s7
Announcing the ACS150 JACS Symposium Series: CSJ Spring Meeting! 📍Nihon University - Funabashi, Japan 📅 18 March 2026
November 14, 2025 at 12:01 AM
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A supplementary cover from this week's #JACS: "Single-Cell Fluorescence Analysis of Lipid Droplet Compositional Dynamics during Triacylglycerol Catabolism"

Discover the research behind the art 🔗: buff.ly/sprY3rG
JACS Supplementary Cover Volume 147, Issue 45 Week Commencing Nov 10
November 13, 2025 at 2:02 PM
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Introducing our latest issue of #JACS! Check out its front cover: "Specifically Adsorbed Carbonate Ions and Copper Surface Reconstruction: The Effect of Double Layer Charging Revealed by Time-Resolved Sum Frequency Generation Spectroscopy"

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JACS Front Cover Volume 147, Issue 45 Week Commencing Nov 10
November 12, 2025 at 2:00 PM
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Another cover from the latest issue of #JACS: ‘Mechanistic Insights into the Borane-Mediated Conversion of 5-Carboxylcytosine to Dihydrouracil in DNA Enable an Efficient Labeling Method Using Alkoxyamines’.

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Supplementary Cover of JACS Vol 147/Issue 44 Week Commencing November 3, 2025
November 11, 2025 at 1:01 PM
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A supplementary cover from the latest issue of #JACS: ‘Modulating Hydrogen Exchange Capabilities by Heterogenizing Pd Nanoclusters onto Ni3C Multipods for Efficiently Driving the “Formaldehyde-Nitrate” Tandem Electrochemical System’.

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Supplementary Cover of JACS Vol 147/Issue 44 Week Commencing November 3, 2025
November 10, 2025 at 1:02 PM
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Another cover featured in this week’s #JACS: ‘Chemically Induced Ferroic-like Phase and Collective Chemotaxis in an Active Swarm’.

Explore the research behind the art: buff.ly/kxHWtTM
Supplementary Cover of JACS Vol 147/Issue 44 Week Commencing November 3, 2025
November 7, 2025 at 1:02 PM
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Introducing a supplementary cover taken from this week’s #JACS issue: ‘Boosting Electrochemical CO2 Reduction to Formate over La-Doped SnO2 via Pinning Effect and Water Activation’.

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Supplementary Cover of JACS Vol 147/Issue 44 Week Commencing November 3, 2025
November 6, 2025 at 1:02 PM
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‘Chirality-Regulated Spin-Polarization of Perovskite Nanoplates for Photocatalytic CO2 Reduction Reaction’ has made the front cover of this week’s #JACS!

Explore this Open Access research: buff.ly/91QLI0T
Front Cover of JACS Vol 147/Issue 44 Week Commencing November 3, 2025
November 5, 2025 at 1:00 PM
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Check out another cover from our latest issue of #JACS: 'Self-Assembly of Artificial Topological Nanostructures for Enhanced Bioorthogonal Activation and Drug Penetration for Cancer Immunotherapy’

Explore the research behind the art: buff.ly/d6HyuDR
Supplementary Cover of JACS Vol 147/Issue 43 Week Commencing October 27 2025
November 4, 2025 at 1:02 PM
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Explore the science behind this striking supplementary cover from #JACS: ‘Size-Dependent Restructuring of Supported Platinum Cluster Catalysts’.

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Supplementary Cover of JACS Vol 147/Issue 43 Week Commencing October 27 2025
November 3, 2025 at 1:02 PM
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Another cover featured in this week’s #JACS: ‘Dual-Site Cobalt-Doped RuO₂/TiO₂ Electrocatalyst Enables Stable and Cost-Efficient Acidic Oxygen Evolution for PEM Water Electrolysis’.

Explore the research behind the art: buff.ly/sImLea5
Supplementary Cover of JACS Vol 147/Issue 43 Week Commencing October 27 2025
October 31, 2025 at 12:01 PM
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Introducing a supplementary cover taken from this week’s #JACS issue: ‘Kinetically Programmed Signaling Cascades for Molecular Detection’.

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Supplementary Cover of JACS Vol 147/Issue 43 Week Commencing October 27 2025
October 30, 2025 at 12:02 PM
jacs.acspublications.org
‘Size-Dependent Restructuring of Supported Platinum Cluster Catalysts’ has made the front cover of this week’s #JACS!

Explore this research, and our latest issue: buff.ly/3XFJGyD
Front Cover of JACS Vol 147/Issue 43 Week Commencing October 27 2025
October 29, 2025 at 12:00 PM
Reposted by Journal of the American Chemical Society (JACS)
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We bind supramolecular helicates to DNA junctions as lock-and-key and now induced-fit too! Exploring how a helicate's size, shape and symmetry affect structures of #DNAjunctions @jacs.acspublications.org

pubs.acs.org/doi/10.1021/...

Congratulations Sam, Hugo and Sumit @uobchemistry.bsky.social
October 27, 2025 at 5:19 PM
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Another supplementary cover from the latest issue of #JACS: "Turning 2D MOFs into Mixed Ionic-Electronic Conductors via Side Chain Engineering"

Discover the research behind the art 🔗: buff.ly/zbZRrQh

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JACS Supplementary Cover Volume 147, Issue 42 Week Commencing October 20
October 28, 2025 at 11:02 AM
jacs.acspublications.org
Another supplementary cover from the latest issue of #JACS: "Strategic Fermi Level Engineering of Donor–Acceptor Self-Assembled Monolayer toward Ultrahigh Paired-Pulse Facilitations in Photosynaptic Transistors"

Discover the research behind the art 🔗: buff.ly/zm55FB3

#ChemSky
JACS Supplementary Cover Volume 147, Issue 42 Week Commencing October 20
October 27, 2025 at 11:03 AM