Ryan Jackson Lab
@jackson-lab-usu.bsky.social
We determine the structure and function of newly discovered bacterial immune systems to uncover novel biotechnologies.
Reposted by Ryan Jackson Lab
Save the date! The CRISPR 2026 meeting will be held June 10 - 12 at Yale University, New Haven, Connecticut, USA. Abstract submissions will be opened on February 1st. Spread the word.
January 17, 2026 at 9:45 PM
Save the date! The CRISPR 2026 meeting will be held June 10 - 12 at Yale University, New Haven, Connecticut, USA. Abstract submissions will be opened on February 1st. Spread the word.
Reposted by Ryan Jackson Lab
Our paper is out! Hiding in plain sight among Cas12a nucleases, Cas12a3 cleaves not its RNA target but the 3′ ends of tRNA. Huge thanks to all who made this possible, especially the Beisel lab, Biao & Dirk for the structure, & @sebastianglatt.bsky.social for all things tRNA. doi.org/10.1038/s415...
RNA-triggered Cas12a3 cleaves tRNA tails to execute bacterial immunity - Nature
Cas12a3 nucleases constitute a distinct clade of type V CRISPR–Cas bacterial immune systems that preferentially cleave the 3′ tails of tRNAs after recognition of target RNA to induce growth arres...
www.nature.com
January 7, 2026 at 4:15 PM
Our paper is out! Hiding in plain sight among Cas12a nucleases, Cas12a3 cleaves not its RNA target but the 3′ ends of tRNA. Huge thanks to all who made this possible, especially the Beisel lab, Biao & Dirk for the structure, & @sebastianglatt.bsky.social for all things tRNA. doi.org/10.1038/s415...