Ivan Liachko
@ivanliachko.bsky.social
Scientist, father, founder/CEO of PhaseGenomics; opinions are my own and probably not the position of the company.
Time for our End of Year sale! If you need an excuse to talk to me about science, this is one way to get there (but also, I'll do it for free 🧬 ❤️ )
Save 25% on Hi-C kits through Dec 31. From complex plant genomes to metagenome binning, Phase Genomics brings clarity to your toughest research questions. Email [email protected] with "25 in '25 Kit Promo" in the subject line to claim your discount.
November 25, 2025 at 8:36 PM
Time for our End of Year sale! If you need an excuse to talk to me about science, this is one way to get there (but also, I'll do it for free 🧬 ❤️ )
Reposted by Ivan Liachko
🌿 New in @NaturePlants! Researchers used Phase Genomics’ Hi-C to build a haplotype-resolved chromosome-scale #genome of a hybrid eelgrass (Zostera marina × Z. pacifica), revealing genomic clues to low-light tolerance that could boost coastal restoration. www.nature.com/articles/s41...
Hybridization and low-light adaptability in California eelgrass (Zostera spp.) - Nature Plants
Seagrass genomes of the deep-water Zostera pacifica and shallow-water Z. marina from the Eastern Pacific Ocean provide evidence for low-light adaptation exemplified in the wild hybrid Z. marina × paci...
www.nature.com
November 6, 2025 at 7:27 PM
🌿 New in @NaturePlants! Researchers used Phase Genomics’ Hi-C to build a haplotype-resolved chromosome-scale #genome of a hybrid eelgrass (Zostera marina × Z. pacifica), revealing genomic clues to low-light tolerance that could boost coastal restoration. www.nature.com/articles/s41...
Reposted by Ivan Liachko
Phase Genomics’ Hi-C tech helped undergrads assemble the “best duckweed genome yet,” giving them hands-on research experience, boosting PhD prospects, and advancing plant biology. Full story from Alex Harkess at HudsonAlpha on YouTube: na2.hubs.ly/H01P7mG0
October 28, 2025 at 3:31 PM
Phase Genomics’ Hi-C tech helped undergrads assemble the “best duckweed genome yet,” giving them hands-on research experience, boosting PhD prospects, and advancing plant biology. Full story from Alex Harkess at HudsonAlpha on YouTube: na2.hubs.ly/H01P7mG0
Reposted by Ivan Liachko
Happy #WorldPhageDay.
Tiny, abundant, and anything but boring, phages shape microbial communities, move genes around, and can tip the balance in all kinds of ecosystems.
The catch: to know a #phage only you must know its host. ProxiMeta Hi-C technology gives us that link.
Tiny, abundant, and anything but boring, phages shape microbial communities, move genes around, and can tip the balance in all kinds of ecosystems.
The catch: to know a #phage only you must know its host. ProxiMeta Hi-C technology gives us that link.
October 22, 2025 at 6:33 PM
Happy #WorldPhageDay.
Tiny, abundant, and anything but boring, phages shape microbial communities, move genes around, and can tip the balance in all kinds of ecosystems.
The catch: to know a #phage only you must know its host. ProxiMeta Hi-C technology gives us that link.
Tiny, abundant, and anything but boring, phages shape microbial communities, move genes around, and can tip the balance in all kinds of ecosystems.
The catch: to know a #phage only you must know its host. ProxiMeta Hi-C technology gives us that link.
Reposted by Ivan Liachko
🌳 New chromosome-level Ulmus minor (field elm) genome unlocks clues to Dutch elm disease resistance. Using long reads and Hi-C, the team built this 2.1Gb genome and mapped clusters of resistance genes conserved across elm species to aid restoration.
na2.hubs.ly/H01HQ2Q0
na2.hubs.ly/H01HQ2Q0
October 21, 2025 at 8:25 PM
🌳 New chromosome-level Ulmus minor (field elm) genome unlocks clues to Dutch elm disease resistance. Using long reads and Hi-C, the team built this 2.1Gb genome and mapped clusters of resistance genes conserved across elm species to aid restoration.
na2.hubs.ly/H01HQ2Q0
na2.hubs.ly/H01HQ2Q0
Reposted by Ivan Liachko
In this great new paper, the authors use metagenomic Hi-C to show that #phage with broad host range are fairly common, contrary to the prevailing view on their biology. Cutting edge methods like Hi-C are shedding light on our blind spots in the microbial world.
Phages with a broad host range are common across ecosystems - Nature Microbiology
Proximity-ligation-based sequencing from 111 samples and 5 environments reveals that a substantial proportion of phages infect multiple species.
www.nature.com
September 29, 2025 at 5:32 PM
In this great new paper, the authors use metagenomic Hi-C to show that #phage with broad host range are fairly common, contrary to the prevailing view on their biology. Cutting edge methods like Hi-C are shedding light on our blind spots in the microbial world.
Reposted by Ivan Liachko
Join us at the Microbiome Innovation One Health Conference in Oxford on Sept 15! @ivanliachko.bsky.social will present how ProxiMeta™ maps microbes, viruses, plasmids & resistance genes, bringing clarity to complexity across human, animal and environmental health.
September 11, 2025 at 5:52 PM
Join us at the Microbiome Innovation One Health Conference in Oxford on Sept 15! @ivanliachko.bsky.social will present how ProxiMeta™ maps microbes, viruses, plasmids & resistance genes, bringing clarity to complexity across human, animal and environmental health.
Reposted by Ivan Liachko
🧬 Important Slug News!
Researchers assembled a chromosome-scale #genome for Deroceras laeve using Proximo Hi-C and @pacbio.bsky.social - making it a useful model for study of #genomics, #evolution, and slimyness... Congrats to Alfredo Varela-Echavarría & team!
🔗 academic.oup.com/g3journal/ad...
Researchers assembled a chromosome-scale #genome for Deroceras laeve using Proximo Hi-C and @pacbio.bsky.social - making it a useful model for study of #genomics, #evolution, and slimyness... Congrats to Alfredo Varela-Echavarría & team!
🔗 academic.oup.com/g3journal/ad...
September 4, 2025 at 4:46 PM
🧬 Important Slug News!
Researchers assembled a chromosome-scale #genome for Deroceras laeve using Proximo Hi-C and @pacbio.bsky.social - making it a useful model for study of #genomics, #evolution, and slimyness... Congrats to Alfredo Varela-Echavarría & team!
🔗 academic.oup.com/g3journal/ad...
Researchers assembled a chromosome-scale #genome for Deroceras laeve using Proximo Hi-C and @pacbio.bsky.social - making it a useful model for study of #genomics, #evolution, and slimyness... Congrats to Alfredo Varela-Echavarría & team!
🔗 academic.oup.com/g3journal/ad...
Reposted by Ivan Liachko
Glad I saw @ivanliachko.bsky.social present on mind-blowing applications of proximity ligation, including metagenomics--linking plasmids, phages and genomes across microbiomes. I see major impact for precision #phagetherapy (and #onehealth)
Godspeed @phasegenomics.bsky.social
tinyurl.com/yaubcrpt
Godspeed @phasegenomics.bsky.social
tinyurl.com/yaubcrpt
The Future of Phage Therapy: Can Bacteriophages Replace Antibiotics? |
Witness how Phase Genomics revolutionizes DNA analysis through Hi-C technology, enabling breakthroughs in microbiome research, cancer diagnostics, and bacteriophage therapeutics to combat antibiotic r...
www.scispot.com
August 28, 2025 at 9:06 AM
Glad I saw @ivanliachko.bsky.social present on mind-blowing applications of proximity ligation, including metagenomics--linking plasmids, phages and genomes across microbiomes. I see major impact for precision #phagetherapy (and #onehealth)
Godspeed @phasegenomics.bsky.social
tinyurl.com/yaubcrpt
Godspeed @phasegenomics.bsky.social
tinyurl.com/yaubcrpt
Reposted by Ivan Liachko
A fungus among us: Proximo Hi‑C + @pacbio.bsky.social HiFi produced telomere‑to‑telomere genomes for VCG‑01111/01112, uncovering 4 accessory chromosomes, >3.6 My divergence, SIX6 and novel effectors—pinpointing drivers of high virulence. www.mdpi.com/2309-608X/11...
August 21, 2025 at 6:33 PM
A fungus among us: Proximo Hi‑C + @pacbio.bsky.social HiFi produced telomere‑to‑telomere genomes for VCG‑01111/01112, uncovering 4 accessory chromosomes, >3.6 My divergence, SIX6 and novel effectors—pinpointing drivers of high virulence. www.mdpi.com/2309-608X/11...
Reposted by Ivan Liachko
She doesn’t need a hero, she is the hero we need. 🤩
August 17, 2025 at 4:41 PM
She doesn’t need a hero, she is the hero we need. 🤩
New study uses long-read + @phasegenomics.bsky.social Hi-C to assemble chromosome-scale #genome of Trichomonas vaginalis and bird-infecting relatives, revealing key genes tied to bird-to-human spillover. Congrats to Jane Carlton, @mikeschatz.bsky.social and team!
Comparative genomics of the parasite Trichomonas vaginalis reveals genes involved in spillover from birds to humans - Nature Communications
The sexually transmitted human parasite Trichomonas vaginalis belongs to a clade of host-switching trichomonads that parasitize mammals, birds, livestock, and pets. Here the authors describe a chromos...
nature.com
August 12, 2025 at 4:53 PM
New study uses long-read + @phasegenomics.bsky.social Hi-C to assemble chromosome-scale #genome of Trichomonas vaginalis and bird-infecting relatives, revealing key genes tied to bird-to-human spillover. Congrats to Jane Carlton, @mikeschatz.bsky.social and team!
Reposted by Ivan Liachko
Structural variants often go undetected by traditional cytogenetics. A new review in Genes shows how Genomic Proximity Mapping™ (GPM) detects complex SVs right from FFPE. Read more Dr. Patrick Gonzales at the University of Kansas Medical Center: www.mdpi.com/2073-4425/16...
August 6, 2025 at 4:28 PM
Structural variants often go undetected by traditional cytogenetics. A new review in Genes shows how Genomic Proximity Mapping™ (GPM) detects complex SVs right from FFPE. Read more Dr. Patrick Gonzales at the University of Kansas Medical Center: www.mdpi.com/2073-4425/16...
Reposted by Ivan Liachko
When sample quality is low, insight usually is too. Not with Genomic Proximity Mapping™ (GPM).
Phase Genomics’ GPM works on #FFPE and mosaic samples. It’s just one assay, no metaphase prep, and no tradeoff in resolution. A new preprint shows how: www.medrxiv.org/content/10.1...
Phase Genomics’ GPM works on #FFPE and mosaic samples. It’s just one assay, no metaphase prep, and no tradeoff in resolution. A new preprint shows how: www.medrxiv.org/content/10.1...
August 4, 2025 at 5:50 PM
When sample quality is low, insight usually is too. Not with Genomic Proximity Mapping™ (GPM).
Phase Genomics’ GPM works on #FFPE and mosaic samples. It’s just one assay, no metaphase prep, and no tradeoff in resolution. A new preprint shows how: www.medrxiv.org/content/10.1...
Phase Genomics’ GPM works on #FFPE and mosaic samples. It’s just one assay, no metaphase prep, and no tradeoff in resolution. A new preprint shows how: www.medrxiv.org/content/10.1...
Reposted by Ivan Liachko
This is very cool
A major advance in the field of human #genetics and #cancer #genomics! As always, we are proud to have been able to contribute our small part to this huge undertaking.
🧬 130 haplotypes, many T2T
🧬 Closed 92% of assembly gaps
🧬 1,852 complex SVs
🧬 1,246 centromeres
www.nature.com/articles/s41...
🧬 130 haplotypes, many T2T
🧬 Closed 92% of assembly gaps
🧬 1,852 complex SVs
🧬 1,246 centromeres
www.nature.com/articles/s41...
Complex genetic variation in nearly complete human genomes - Nature
Using sequencing and haplotype-resolved assembly of 65 diverse human genomes, complex regions including the major histocompatibility complex and centromeres are analysed.
www.nature.com
July 28, 2025 at 5:55 PM
This is very cool
Reposted by Ivan Liachko
🌸 Chromosome-scale genome of Petunia hybrida assembled with Proximo Hi-C, PacBio HiFi, Illumina & Bionano. 7 pseudochromosomes, 99.8% BUSCO with Hi-C being key for resolving repeats. A powerful resource for Solanaceae genetics & breeding. #genome #HiC
📄 hubs.la/Q03ypPmb0
📄 hubs.la/Q03ypPmb0
July 25, 2025 at 6:11 AM
🌸 Chromosome-scale genome of Petunia hybrida assembled with Proximo Hi-C, PacBio HiFi, Illumina & Bionano. 7 pseudochromosomes, 99.8% BUSCO with Hi-C being key for resolving repeats. A powerful resource for Solanaceae genetics & breeding. #genome #HiC
📄 hubs.la/Q03ypPmb0
📄 hubs.la/Q03ypPmb0
By popular demand by you, #genomics people - this buffer is super useful for Hi-C and we'll give you some if you ask for it, no strings attached.
July 23, 2025 at 7:49 PM
By popular demand by you, #genomics people - this buffer is super useful for Hi-C and we'll give you some if you ask for it, no strings attached.
Reposted by Ivan Liachko
🌱🧬Researchers released haplotype-resolved, chromosome-level genomes of Eupatorium splendens - a plant known for medicinal properties and ability to thrive in contaminated soils. A powerful resource for studying stress adaptation & secondary metabolism. www.nature.com/articles/s41...
Haplotype-resolved chromosome-level genome sequence of Elsholtzia splendens (Nakai ex F.Maek.) - Scientific Data
Scientific Data - Haplotype-resolved chromosome-level genome sequence of Elsholtzia splendens (Nakai ex F.Maek.)
www.nature.com
July 22, 2025 at 6:34 PM
🌱🧬Researchers released haplotype-resolved, chromosome-level genomes of Eupatorium splendens - a plant known for medicinal properties and ability to thrive in contaminated soils. A powerful resource for studying stress adaptation & secondary metabolism. www.nature.com/articles/s41...
Reposted by Ivan Liachko
🍓 Meet ‘Yuexin’ - a next-gen #strawberry with smoother texture, better shelf life, and sweeter aroma. Scientists have released its fully phased #genome, revealing the genetic secrets behind these tasty traits. Proximo #HiC +
@pacbio.bsky.social for the win! 🧬
🔗 hubs.la/Q03tZvZD0
@pacbio.bsky.social for the win! 🧬
🔗 hubs.la/Q03tZvZD0
July 15, 2025 at 8:07 PM
🍓 Meet ‘Yuexin’ - a next-gen #strawberry with smoother texture, better shelf life, and sweeter aroma. Scientists have released its fully phased #genome, revealing the genetic secrets behind these tasty traits. Proximo #HiC +
@pacbio.bsky.social for the win! 🧬
🔗 hubs.la/Q03tZvZD0
@pacbio.bsky.social for the win! 🧬
🔗 hubs.la/Q03tZvZD0
Reposted by Ivan Liachko
“It’s not a brute force technology. It’s a clever technology.”
— Jon Chee, CEO @ Excedr
In the finale of The Biotech Startups Podcast, Jon and @ivanliachko.bsky.social unpack how smart science powers Phase Genomics' impact in cancer research, metagenomics & more👇
youtu.be/fqL6ZvS2sNQ?...
— Jon Chee, CEO @ Excedr
In the finale of The Biotech Startups Podcast, Jon and @ivanliachko.bsky.social unpack how smart science powers Phase Genomics' impact in cancer research, metagenomics & more👇
youtu.be/fqL6ZvS2sNQ?...
Growth Without Venture Capital: The Bootstrapped Biotech Playbook | Ivan Liachko (Part 4/4)
YouTube video by The Biotech Startups Podcast | Excedr
youtu.be
July 9, 2025 at 4:28 PM
“It’s not a brute force technology. It’s a clever technology.”
— Jon Chee, CEO @ Excedr
In the finale of The Biotech Startups Podcast, Jon and @ivanliachko.bsky.social unpack how smart science powers Phase Genomics' impact in cancer research, metagenomics & more👇
youtu.be/fqL6ZvS2sNQ?...
— Jon Chee, CEO @ Excedr
In the finale of The Biotech Startups Podcast, Jon and @ivanliachko.bsky.social unpack how smart science powers Phase Genomics' impact in cancer research, metagenomics & more👇
youtu.be/fqL6ZvS2sNQ?...
Reposted by Ivan Liachko
New💩🚰👨🔬 study in #EnvMicrobiology uses shotgun & Hi-C metagenomics to reveal rapid shifts in antibiotic resistance genes and their microbial hosts, highlighting the dynamic nature of resistomes. #AMR #Metagenomics
🔗https://hubs.la/Q03tZ1Jf0
🔗https://hubs.la/Q03tZ1Jf0
July 8, 2025 at 8:11 PM
New💩🚰👨🔬 study in #EnvMicrobiology uses shotgun & Hi-C metagenomics to reveal rapid shifts in antibiotic resistance genes and their microbial hosts, highlighting the dynamic nature of resistomes. #AMR #Metagenomics
🔗https://hubs.la/Q03tZ1Jf0
🔗https://hubs.la/Q03tZ1Jf0
Reposted by Ivan Liachko
TBT: 🧬 Throwing it back to a cool study from Aug 2021! Using proximity ligation, this paper explores the two-compartment genome of R. irregularis, a model arbuscular mycorrhizal symbiont, using Proximo #HiC and @nanoporetech.com sequencing. @Blunt_Microbe
🔗 Full study: hubs.la/Q03tZ6Ch0
🔗 Full study: hubs.la/Q03tZ6Ch0
July 3, 2025 at 5:18 PM
TBT: 🧬 Throwing it back to a cool study from Aug 2021! Using proximity ligation, this paper explores the two-compartment genome of R. irregularis, a model arbuscular mycorrhizal symbiont, using Proximo #HiC and @nanoporetech.com sequencing. @Blunt_Microbe
🔗 Full study: hubs.la/Q03tZ6Ch0
🔗 Full study: hubs.la/Q03tZ6Ch0
Reposted by Ivan Liachko
“If we don’t commercialize this, it’s going to be a crime against science.” - @ivanliachko.bsky.social, Founder and CEO
Hear how a postdoc aha moment became a platform accelerating #microbiome research, tackling #AMR & more on the Biotech Startups Podcast: www.youtube.com/watch?v=U2UG...
Hear how a postdoc aha moment became a platform accelerating #microbiome research, tackling #AMR & more on the Biotech Startups Podcast: www.youtube.com/watch?v=U2UG...
How 3D Genome Mapping is Changing Everything We Know About DNA | Ivan Liachko (Part 3/4)
YouTube video by The Biotech Startups Podcast | Excedr
www.youtube.com
July 2, 2025 at 5:57 PM
“If we don’t commercialize this, it’s going to be a crime against science.” - @ivanliachko.bsky.social, Founder and CEO
Hear how a postdoc aha moment became a platform accelerating #microbiome research, tackling #AMR & more on the Biotech Startups Podcast: www.youtube.com/watch?v=U2UG...
Hear how a postdoc aha moment became a platform accelerating #microbiome research, tackling #AMR & more on the Biotech Startups Podcast: www.youtube.com/watch?v=U2UG...
Reposted by Ivan Liachko
Unleashing the wild side of lupins! 🌕🐺🍃
Researchers built #genomes of rough-seeded lupins - L. cosentinii & L. digitatus - revealing unique #gene expansions tied to stress resilience and seed traits. A howling good resource for legume breeding! #HiC
🔗 hubs.la/Q03v1F2c0
Researchers built #genomes of rough-seeded lupins - L. cosentinii & L. digitatus - revealing unique #gene expansions tied to stress resilience and seed traits. A howling good resource for legume breeding! #HiC
🔗 hubs.la/Q03v1F2c0
July 1, 2025 at 8:45 PM
Unleashing the wild side of lupins! 🌕🐺🍃
Researchers built #genomes of rough-seeded lupins - L. cosentinii & L. digitatus - revealing unique #gene expansions tied to stress resilience and seed traits. A howling good resource for legume breeding! #HiC
🔗 hubs.la/Q03v1F2c0
Researchers built #genomes of rough-seeded lupins - L. cosentinii & L. digitatus - revealing unique #gene expansions tied to stress resilience and seed traits. A howling good resource for legume breeding! #HiC
🔗 hubs.la/Q03v1F2c0