UPENN_ITMAT
@itmat.bsky.social
ITMAT was launched formally in January 2005; the first Institute of Translational Medicine And Therapeutics in the world.
Wishing you a joyful and restful Thanksgiving!
November 25, 2025 at 10:27 PM
Wishing you a joyful and restful Thanksgiving!
Molecular insights to potentially prevent #BetaCell failure in #Type2Diabetes doi.org/10.1016/j.mo... #T2D #DiabetesResearch #IsletBiology #TranslationalScience
August 26, 2025 at 5:50 PM
Molecular insights to potentially prevent #BetaCell failure in #Type2Diabetes doi.org/10.1016/j.mo... #T2D #DiabetesResearch #IsletBiology #TranslationalScience
#Neuropeptides essential for complex social behavior with phenotypic plasticity in social insect model doi.org/10.1016/j.ce... #SocialAnalysis #SocialHierarchy #TranslationalScience
July 29, 2025 at 6:38 PM
#Neuropeptides essential for complex social behavior with phenotypic plasticity in social insect model doi.org/10.1016/j.ce... #SocialAnalysis #SocialHierarchy #TranslationalScience
Join us via Zoom!
Register Here: tinyurl.com/virtualTRIPICA
Register Here: tinyurl.com/virtualTRIPICA
July 24, 2025 at 5:55 PM
Join us via Zoom!
Register Here: tinyurl.com/virtualTRIPICA
Register Here: tinyurl.com/virtualTRIPICA
Examining mechanisms relevant for restoring #Erythropoiesis & mitigation of pro-inflammatory IFNγ action in #MouseModel #Anemia of #Inflammation (AI) doi.org/10.1182/bloo... #TranslationalScience
July 22, 2025 at 8:51 PM
Examining mechanisms relevant for restoring #Erythropoiesis & mitigation of pro-inflammatory IFNγ action in #MouseModel #Anemia of #Inflammation (AI) doi.org/10.1182/bloo... #TranslationalScience
You’re Invited: Where Science Meets Art: ITMAT Artist-in-Residence Ceramic Showcase on 7/24 from 5-7 PM at the Institute for Contemporary Art in Philadelphia, PA!
RSVP at www.instagram.com/upenn_itmat/
RSVP at www.instagram.com/upenn_itmat/
July 15, 2025 at 7:38 PM
You’re Invited: Where Science Meets Art: ITMAT Artist-in-Residence Ceramic Showcase on 7/24 from 5-7 PM at the Institute for Contemporary Art in Philadelphia, PA!
RSVP at www.instagram.com/upenn_itmat/
RSVP at www.instagram.com/upenn_itmat/
#AdolescentBrain: #SexDifferences in the spatial organization of functional #Brain networks accentuated in association networks especially in frontoparietal & ventral attention networks doi.org/10.1192/bjp.... #MentalHealth #TranslationalScience
July 1, 2025 at 12:01 PM
#AdolescentBrain: #SexDifferences in the spatial organization of functional #Brain networks accentuated in association networks especially in frontoparietal & ventral attention networks doi.org/10.1192/bjp.... #MentalHealth #TranslationalScience
How do biological systems interact with foreign materials? How is decision-making reflected in biological signaling networks? Using complement activation as a model system doi.org/10.1016/j.ce... dives into these questions @jakebrenner #TranslationalScience
June 24, 2025 at 12:05 PM
How do biological systems interact with foreign materials? How is decision-making reflected in biological signaling networks? Using complement activation as a model system doi.org/10.1016/j.ce... dives into these questions @jakebrenner #TranslationalScience
Unraveling the often undefined pathogenesis of #MyxomatousValveDisease (MVD) doi.org/10.1172/JCI1... #SignalingMechanism #ValveDisease #HeartValve #CardiacHealth #TranslationalScience
June 18, 2025 at 9:40 PM
Unraveling the often undefined pathogenesis of #MyxomatousValveDisease (MVD) doi.org/10.1172/JCI1... #SignalingMechanism #ValveDisease #HeartValve #CardiacHealth #TranslationalScience
Building the foundation to address the mechanistic gap between two hallmarks of #Neurodegeneration: excitotoxicity and RNA regulation by #RNA #BindingProteins (RBPs). doi.org/10.1016/j.is... @KJSsci #NeuroSci #MolecularBiology #TranslationalScience
June 13, 2025 at 5:02 PM
Building the foundation to address the mechanistic gap between two hallmarks of #Neurodegeneration: excitotoxicity and RNA regulation by #RNA #BindingProteins (RBPs). doi.org/10.1016/j.is... @KJSsci #NeuroSci #MolecularBiology #TranslationalScience
Engineering genetic approaches to develop a CAR-T cell therapy efficaciously targeting #SolidTumor doi.org/10.1016/j.cc... @DJPowellLab #NeoCARs #CellTherapy #CARTCell #GeneTherapy #ImmunoTherapy #Oncology #TranslationalScience
June 10, 2025 at 1:50 PM
Engineering genetic approaches to develop a CAR-T cell therapy efficaciously targeting #SolidTumor doi.org/10.1016/j.cc... @DJPowellLab #NeoCARs #CellTherapy #CARTCell #GeneTherapy #ImmunoTherapy #Oncology #TranslationalScience
Waking up after #Anesthesia: Neuronal dynamics model predicts both population- and individual-level features of emergence doi.org/10.1016/j.bj... #Anaesthesia #Anesthesiology #Anaesthesiology #TranslationalScience
May 1, 2025 at 5:49 PM
Waking up after #Anesthesia: Neuronal dynamics model predicts both population- and individual-level features of emergence doi.org/10.1016/j.bj... #Anaesthesia #Anesthesiology #Anaesthesiology #TranslationalScience
Characterizing molecular programs guiding #CardioPulmonary maturation through integration of #SpatialTranscriptomics with #Computational #CellTrajectory analysis and #TranscriptionalProfiling doi.org/10.1016/j.ce... #CellAtlas #TranslationalScience
April 8, 2025 at 6:59 PM
Characterizing molecular programs guiding #CardioPulmonary maturation through integration of #SpatialTranscriptomics with #Computational #CellTrajectory analysis and #TranscriptionalProfiling doi.org/10.1016/j.ce... #CellAtlas #TranslationalScience
Novel non-anticoagulant therapeutics to curb the immune response in Heparin-Induced #Thrombocytopenia #HIT doi.org/10.1182/bloo... #DrugDevelopment #TranslationalScience
March 27, 2025 at 8:13 PM
Novel non-anticoagulant therapeutics to curb the immune response in Heparin-Induced #Thrombocytopenia #HIT doi.org/10.1182/bloo... #DrugDevelopment #TranslationalScience
The most important test in science is the test of time: A perspective on data, fraud, trust & validity doi.org/10.1017/jme.... @FitzGerald__Lab #ScienceIntegrity #TranslationalScience
March 25, 2025 at 10:23 PM
The most important test in science is the test of time: A perspective on data, fraud, trust & validity doi.org/10.1017/jme.... @FitzGerald__Lab #ScienceIntegrity #TranslationalScience
Early nonresponse to behavioral obesity treatment doesn’t have to mean failure. Adding anti-obesity medication doubles weight loss. doi.org/10.1038/s415... #ObesityResearch #WeightLossScience #TranslationalScience
March 13, 2025 at 10:22 PM
Early nonresponse to behavioral obesity treatment doesn’t have to mean failure. Adding anti-obesity medication doubles weight loss. doi.org/10.1038/s415... #ObesityResearch #WeightLossScience #TranslationalScience
Check this out! Monitoring the spatiotemporal dynamics of #mRNAvaccine antigen expression in vivo www.nature.com/articles/s41... @drewweissmanlab.bsky.social #TranslationalScience
March 6, 2025 at 10:07 PM
Check this out! Monitoring the spatiotemporal dynamics of #mRNAvaccine antigen expression in vivo www.nature.com/articles/s41... @drewweissmanlab.bsky.social #TranslationalScience
Multi-population study into genetic architecture of human #KidneyFunction discovers 124 genes amenable to targeting by FDA-approved drugs doi.org/10.1126/scie... @ksusztak.bsky.social @marylynritchie.bsky.social #TranslationalScience #DrugRepurposing
March 5, 2025 at 3:39 AM
Multi-population study into genetic architecture of human #KidneyFunction discovers 124 genes amenable to targeting by FDA-approved drugs doi.org/10.1126/scie... @ksusztak.bsky.social @marylynritchie.bsky.social #TranslationalScience #DrugRepurposing
Advancing our understanding of immunogenic epitope selection, with implications for #VaccineDevelopment and T cell–based therapies. doi.org/10.1073/pnas... #CryoEM @moiseenkovabell #TranslationalScience
February 27, 2025 at 7:16 PM
Advancing our understanding of immunogenic epitope selection, with implications for #VaccineDevelopment and T cell–based therapies. doi.org/10.1073/pnas... #CryoEM @moiseenkovabell #TranslationalScience
Promising leads in therapeutic advances for metabolic dysfunction-associated steatotic #LiverDisease (#MASLD) doi.org/10.1016/j.cm... @WellenLab
February 25, 2025 at 8:57 PM
Promising leads in therapeutic advances for metabolic dysfunction-associated steatotic #LiverDisease (#MASLD) doi.org/10.1016/j.cm... @WellenLab
Extending the #OrganOnAChip technology to mimic #BoneMarrow enabling mechanistic studies on injury models, #DrugToxicity, and more. Check out doi.org/10.1016/j.st... @PennEngineers #PennEngineering #TranslationalScience
February 13, 2025 at 5:51 PM
Extending the #OrganOnAChip technology to mimic #BoneMarrow enabling mechanistic studies on injury models, #DrugToxicity, and more. Check out doi.org/10.1016/j.st... @PennEngineers #PennEngineering #TranslationalScience
More ITMAT Winter Party fun!
February 7, 2025 at 4:32 PM
More ITMAT Winter Party fun!
Thank you to all who joined us for the ITMAT Winter Party! What a great night to come together and celebrate another fantastic year. @jonepstein1.bsky.social @pennmedicine.bsky.social @pennmedicine.bsky.social
February 7, 2025 at 4:29 PM
Thank you to all who joined us for the ITMAT Winter Party! What a great night to come together and celebrate another fantastic year. @jonepstein1.bsky.social @pennmedicine.bsky.social @pennmedicine.bsky.social
Common nanoparticle linkers may hijack the #ImmuneSystem, drive toxicity and misdirect #DrugDelivery. However, @jakebrenner lab uncovers molecular mechanisms & develops solutions to mitigate these effects doi.org/10.1002/adma... #Nanomedicine #TranslationalScience
February 4, 2025 at 8:18 PM
Common nanoparticle linkers may hijack the #ImmuneSystem, drive toxicity and misdirect #DrugDelivery. However, @jakebrenner lab uncovers molecular mechanisms & develops solutions to mitigate these effects doi.org/10.1002/adma... #Nanomedicine #TranslationalScience