Isha Jain
@ishahjain.bsky.social
Associate Professor at Gladstone/UCSF. Studying the mysteries of oxygen and vitamins.
Lots of safety/efficacy work still to be done, but hypoxia-based therapies could have broad applications from rare mitochondrial diseases to age-associated neurodegeneration. We are interested in additional partnerships in academia/industry to continue this work. Send me a DM!
February 17, 2025 at 11:53 PM
Lots of safety/efficacy work still to be done, but hypoxia-based therapies could have broad applications from rare mitochondrial diseases to age-associated neurodegeneration. We are interested in additional partnerships in academia/industry to continue this work. Send me a DM!
Huge congratulations to all co-authors -- first-author Skyler Blume and all the folks at Maze (Maarten Hoek, Chris Sinz, Gijs Grotenbreg, Eric Green, Vyas Ramanan and more)!
February 17, 2025 at 11:53 PM
Huge congratulations to all co-authors -- first-author Skyler Blume and all the folks at Maze (Maarten Hoek, Chris Sinz, Gijs Grotenbreg, Eric Green, Vyas Ramanan and more)!
Key Findings:
✅ HypoxyStat induces hypoxia comparable to 11% O₂ inhalation (~4500m altitude).
✅ Extends lifespan 3-4x in the Ndufs4KO mouse model of mitochondrial disease.
✅ Reverses disease pathology—even at late stages!
✅ HypoxyStat induces hypoxia comparable to 11% O₂ inhalation (~4500m altitude).
✅ Extends lifespan 3-4x in the Ndufs4KO mouse model of mitochondrial disease.
✅ Reverses disease pathology—even at late stages!
February 17, 2025 at 11:53 PM
Key Findings:
✅ HypoxyStat induces hypoxia comparable to 11% O₂ inhalation (~4500m altitude).
✅ Extends lifespan 3-4x in the Ndufs4KO mouse model of mitochondrial disease.
✅ Reverses disease pathology—even at late stages!
✅ HypoxyStat induces hypoxia comparable to 11% O₂ inhalation (~4500m altitude).
✅ Extends lifespan 3-4x in the Ndufs4KO mouse model of mitochondrial disease.
✅ Reverses disease pathology—even at late stages!
💊 Enter HypoxyStat—a small molecule that increases how tightly hemoglobin holds onto oxygen, thereby reducing oxygen release into tissues and causing hypoxia without requiring specialized gas environments or moving to the mountains!
February 17, 2025 at 11:53 PM
💊 Enter HypoxyStat—a small molecule that increases how tightly hemoglobin holds onto oxygen, thereby reducing oxygen release into tissues and causing hypoxia without requiring specialized gas environments or moving to the mountains!
A quick thread: mitochondrial dysfunction causes an imbalance in oxygen supply and demand, leading to tissue hyperoxia. We've previously shown that inhaled hypoxia can dramatically extend lifespan in disease models. But how do we translate this into a practical therapy?
February 17, 2025 at 11:53 PM
A quick thread: mitochondrial dysfunction causes an imbalance in oxygen supply and demand, leading to tissue hyperoxia. We've previously shown that inhaled hypoxia can dramatically extend lifespan in disease models. But how do we translate this into a practical therapy?
PS. We're hiring! If you're excited about oxygen or redox cofactor (vitamin) metabolism come work with us @ArcInstitute @GladstoneInst @UCSF! Postdoc candidates, Apply here: grnh.se/7c94a5004us
February 17, 2025 at 11:53 PM
PS. We're hiring! If you're excited about oxygen or redox cofactor (vitamin) metabolism come work with us @ArcInstitute @GladstoneInst @UCSF! Postdoc candidates, Apply here: grnh.se/7c94a5004us