Isaac Li
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isaacli.bsky.social
Isaac Li
@isaacli.bsky.social
Single-molecule biophysicist, building force-responsive DNA to study biology, love space exploration real & sci-fi. 🔬🧬🧫🌟🪐🚀
Associate Professor of Chemistry at UBC Okanagan, Canada Research Chair, Michael Smith Scholar 🍁🇨🇦
https://lilab.ok.ubc.ca/
We just uploaded a preprint on a new massively parallel single-molecule force spectroscopy method. No beads, no messy calibration - just pure DNA tethers pulling individual molecules while we watch them in real-time with fluorescence.
Check it out: www.biorxiv.org/content/10.1...
September 17, 2025 at 11:29 PM
Latest from the lab: 🧬 Decoy DNA 🧬 can extend the lifetime of DNA-based tension probes >24h by outcompeting DNases and preserving signal integrity in live-cell tension imaging. This is a simple, general strategy for robust mechanobiology in DNase-rich environments. doi.org/10.1002/anie...
June 25, 2025 at 8:03 PM
Wonderful visit to the University of Lethbridge -many thanks to Trushar @trushar7.bsky.social and Dylan for the kind hosting! Great discussions with researchers at the Chemistry and Biochemistry Department! 👍
June 24, 2025 at 6:00 AM
Taking the group out for fun outside of the #BSC2025 @biophyscanada.bsky.social annual meeting, visited Niagara Falls, ran into a filming of a featured film, good times!
May 24, 2025 at 12:53 PM
Congratulations 🎉 to Ryan, David, and Irving for winning two poster and a travel award at the @biophyscanada.bsky.social annual meeting! 👏
May 24, 2025 at 12:47 PM
We just published a review of the very recent progress in integrin force loading rate measurement using various molecular tension probes. Learn more about how this has advanced the field and what potential improvement lies ahead here: doi.org/10.1017/qrd....
#mechanobiology #integrin #tensionprobes
March 12, 2025 at 7:57 PM
Hello little one, nice to meet you!
#daimon
December 22, 2024 at 7:27 AM
This is immensely fun to read
doi.org/10.1016/j.ij...
November 18, 2024 at 4:52 PM
Coffee…made
Matlab…opened
Meetings…none
It’s gonna be a great day!
November 15, 2024 at 5:18 PM